TY  - GEN
A1  - Höfer, Chris Tina
A1  - Di Lella, Santiago
A1  - Dahmani, Ismail
A1  - Jungnick, Nadine
A1  - Bordag, Natalie
A1  - Bobone, Sara
A1  - Huan, Q.
A1  - Keller, S.
A1  - Herrmann, A.
A1  - Chiantia, Salvatore
T1  - Corrigendum to: Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes (Biochimica et Biophysica Acta (BBA) - Biomembranes. - 1861, (2019), pg 1123-1134)
T2  - Biochimica et biophysica acta : Biomembranes
Y1  - 2019
U6  - https://doi.org/10.1016/j.bbamem.2019.07.002
SN  - 0005-2736
SN  - 1879-2642
VL  - 1861
IS  - 10
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bordag, Natalie
A1  - Klie, Sebastian
A1  - Jürchott, Kathrin
A1  - Vierheller, Janine
A1  - Schiewe, Hajo
A1  - Albrecht, Valerie
A1  - Tonn, Jörg-Christian
A1  - Schwartz, Christoph
A1  - Schichor, Christian
A1  - Selbig, Joachim
T1  - Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects
JF  - Scientific reports
N2  - Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at (similar to)0.9% of the adult population. Better holistic insights into glucocorticoid-induced changes are crucial for effective use as concurrent medication and management of adverse effects. The profiles of 214 metabolites from plasma of 20 male healthy volunteers were recorded prior to and after ingestion of a single dose of 4 mg dexamethasone (+20 mg pantoprazole). Samples were drawn at three predefined time points per day: seven untreated (day 1 midday - day 3 midday) and four treated (day 3 evening - day 4 evening) per volunteer. Statistical analysis revealed tremendous impact of dexamethasone on the metabolome with 150 of 214 metabolites being significantly deregulated on at least one time point after treatment (ANOVA, Benjamini-Hochberg corrected, q < 0.05). Inter-person variability was high and remained uninfluenced by treatment. The clearly visible circadian rhythm prior to treatment was almost completely suppressed and deregulated by dexamethasone. The results draw a holistic picture of the severe metabolic deregulation induced by single-dose, short-term glucocorticoid application. The observed metabolic changes suggest a potential for early detection of severe side effects, raising hope for personalized early countermeasures increasing quality of life and reducing health care costs.
Y1  - 2015
U6  - https://doi.org/10.1038/srep15954
SN  - 2045-2322
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  -