TY - JOUR A1 - Gianelli, Claudia A1 - Dalla Volta, Riccardo T1 - Does listening to action-related sentences modulate the activity of the motor system? BT - Replication of a combined TMS and behavioral study JF - Frontiers in psychology N2 - The neurophysiological and behavioral correlates of action-related language processing have been debated for long time. A precursor in this field was the study by Buccino et al. (2005) combining transcranial magnetic stimulation (TMS) and behavioral measures (reaction times, RTs) to study the effect of listening to hand- and foot-related sentences. In the TMS experiment, the authors showed a decrease of motor evoked potentials (MEPs) recorded from hand muscles when processing hand-related verbs as compared to foot-related verbs. Similarly, MEPs recorded from leg muscles decreased when participants processed foot-related as compared to hand-related verbs. In the behavioral experiment, using the same stimuli and a semantic decision task the authors found slower RTs when the participants used the body effector (hand or foot) involved in the actual execution of the action expressed by the presented verb to give their motor responses. These findings were interpreted as an interference effect due to a simultaneous involvement of the motor system in both a language and a motor task. Our replication aimed to enlarge the sample size and replicate the findings with higher statistical power. The TMS experiment showed a significant modulation of hand MEPs, but in the sense of a motor facilitation when processing hand-related verbs. On the contrary, the behavioral experiment did not show significant results. The results are discussed within the general debate on the time-course of the modulation of motor cortex during implicit and explicit language processing and in relation to the studies on action observation/understanding. KW - action language KW - motor system KW - TMS KW - motor resonance KW - interference KW - replication Y1 - 2015 U6 - https://doi.org/10.3389/fpsyg.2014.01511 SN - 1664-1078 VL - 5 SP - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Wiebking, Christine A1 - de Greck, Moritz A1 - Duncan, Niall W. A1 - Tempelmann, Claus A1 - Bajbouj, Malek A1 - Northoff, Georg T1 - Interoception in insula subregions as a possible state marker for depression BT - an exploratory fMRI study investigating healthy, depressed and remitted participants JF - Frontiers in behavioral neuroscience N2 - Background: Interoceptive awareness (iA), the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored. Methods: A well-established fMRI paradigm for studying (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups. Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences. Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst non-psychiatric participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus. KW - major depressive disorder KW - interoceptive awareness KW - insula KW - remission KW - neuroimaging KW - fMRI KW - hopelessness KW - interoception Y1 - 2015 U6 - https://doi.org/10.3389/fnbeh.2015.00082 SN - 1662-5153 IS - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Beurskens, Rainer A1 - Mühlbauer, Thomas A1 - Granacher, Urs T1 - Association of dual-task walking performance and leg muscle quality in healthy children JF - BMC pediatrics N2 - Background Previous literature mainly introduced cognitive functions to explain performance decrements in dual-task walking, i.e., changes in dual-task locomotion are attributed to limited cognitive information processing capacities. In this study, we enlarge existing literature and investigate whether leg muscular capacity plays an additional role in children’s dual-task walking performance. Methods To this end, we had prepubescent children (mean age: 8.7 ± 0.5 years, age range: 7–9 years) walk in single task (ST) and while concurrently conducting an arithmetic subtraction task (DT). Additionally, leg lean tissue mass was assessed. Results Findings show that both, boys and girls, significantly decrease their gait velocity (f = 0.73), stride length (f = 0.62) and cadence (f = 0.68) and increase the variability thereof (f = 0.20-0.63) during DT compared to ST. Furthermore, stepwise regressions indicate that leg lean tissue mass is closely associated with step time and the variability thereof during DT (R2 = 0.44, p = 0.009). These associations between gait measures and leg lean tissue mass could not be observed for ST (R2 = 0.17, p = 0.19). Conclusion We were able to show a potential link between leg muscular capacities and DT walking performance in children. We interpret these findings as evidence that higher leg muscle mass in children may mitigate the impact of a cognitive interference task on DT walking performance by inducing enhanced gait stability. KW - Gait KW - Cognitive interference KW - Body composition KW - Muscle mass KW - Children Y1 - 2015 U6 - https://doi.org/10.1186/s12887-015-0317-8 SN - 1471-2431 VL - 15 IS - 2 PB - BioMed Central CY - London ER - TY - THES A1 - Discher, Christian T1 - Sprachkontakt, Migration und Variation BT - die frankophone Integration von Rumänen in Paris nach 1989 T2 - Tübinger Beiträge zur Linguistik ; 549 Y1 - 2013 SN - 978-3-8233-6915-8 PB - Narr CY - Tübingen ER - TY - THES A1 - Zerle-Elsäßer, Claudia T1 - Wer wird Vater und wann? BT - Zur Kinderlosigkeit von Männern und dem Timing einer ersten Vaterschaft im Lebenslauf Y1 - 2014 SN - 978-3-86573-844-8 PB - Wiss. Verl. CY - Berlin ER - TY - THES A1 - Meiners, Johannes T1 - Rechtsnormen und Rationalität BT - Zum Problem der Rechtsgeltung bei Hans Kelsen, Jürgen Habermas und Niklas Luhmann T2 - Schriften zur Rechtstheorie ; 267 Y1 - 2014 SN - 978-3-428-14488-4 PB - Duncker & Humbolt CY - Berlin ER - TY - THES A1 - Emadpour, Masoumeh T1 - Development of tools for inducible gene expression in choroplasts Y1 - 2014 ER - TY - THES A1 - Hanne, Sandra T1 - On the subject-object asymmetry in sentence comprehension in aphasia BT - implications from eye-tracking data and computational modeling Y1 - 2015 ER - TY - THES A1 - Stech, Marlitt T1 - Investigations on the cell-free synthesis of single-chain antibody fragments using a cukaryotic translation system Y1 - 2014 ER - TY - THES A1 - Rudorf, Sophia T1 - Protein Synthesis by Ribosomes Y1 - 2014 ER - TY - THES A1 - Koch, Helvi T1 - Effekte des um Selbstregulationsprozeduren angereicherten reziproken Lehrens BT - Regellehrkräfte als Strategieeinstrukoren zur Förderung der Lesekompetenz von Grundschülern Y1 - 2014 ER - TY - THES A1 - Borchardt, Sven T1 - Rainfall, weathering and erosion BT - quantification of earth surface processes in Suguta Valley, northern Kenya, using multispectral and hyperspectral data Y1 - 2014 ER - TY - THES A1 - Freudenreich, Johannes T1 - Coalition Formation in Presidential Systems Y1 - 2013 ER - TY - JOUR A1 - Zamponi, Flavio A1 - Penfold, Thomas J. A1 - Nachtegaal, Maarten A1 - Lübcke, Andrea A1 - Rittmann, Jochen A1 - Milne, Chris J. A1 - Chergui, Majed A1 - van Bokhoven, Jeroen A. T1 - Probing the dynamics of plasmon-excited hexanethiol-capped gold nanoparticles by picosecond X-ray absorption spectroscopy JF - physical chemistry, chemical physics : PCCP N2 - Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansion of the Au–Au bond length and a large increase in disorder associated with melting of the NPs. Recovery of the ground state occurs with a time constant of ∼1.8 ns, arising from thermalisation with the environment. Simulations reveal that the transient spectrum exhibits no signature of charge separation at 100 ps and allows us to estimate an upper limit for the quantum yield (QY) of this process to be <0.1. KW - TiO2 nanoparticles KW - diimine-complexes KW - electron-transfer KW - supported gold KW - visible-light KW - water KW - surface KW - reactivity KW - nanoclusters KW - excitation Y1 - 2014 U6 - https://doi.org/10.1039/c4cp03301a SN - 1463-9076 SN - 1463-9084 VL - 2014 IS - 16 SP - 23157 EP - 23163 ER - TY - JOUR A1 - Wessig, Pablo A1 - Gerngroß, Maik A1 - Pape, Simon A1 - Bruhns, Philipp A1 - Weber, Jens T1 - Novel porous materials based on oligospiroketals (OSK) JF - RSC Advances : an international journal to further the chemical sciences N2 - New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions. KW - microporous organic polymers KW - molecular rods KW - construction KW - frameworks KW - membranes KW - sorption KW - models Y1 - 2014 U6 - https://doi.org/10.1039/c4ra04437a SN - 2046-2069 VL - 2014 IS - 4 SP - 31123 EP - 31129 ER - TY - JOUR A1 - Metzler, Ralf A1 - Jeon, Jae-Hyung A1 - Cherstvy, Andrey G. A1 - Barkai, Eli T1 - Anomalous diffusion models and their properties BT - non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking JF - physical chemistry, chemical physics : PCCP N2 - Modern microscopic techniques following the stochastic motion of labelled tracer particles have uncovered significant deviations from the laws of Brownian motion in a variety of animate and inanimate systems. Such anomalous diffusion can have different physical origins, which can be identified from careful data analysis. In particular, single particle tracking provides the entire trajectory of the traced particle, which allows one to evaluate different observables to quantify the dynamics of the system under observation. We here provide an extensive overview over different popular anomalous diffusion models and their properties. We pay special attention to their ergodic properties, highlighting the fact that in several of these models the long time averaged mean squared displacement shows a distinct disparity to the regular, ensemble averaged mean squared displacement. In these cases, data obtained from time averages cannot be interpreted by the standard theoretical results for the ensemble averages. Here we therefore provide a comparison of the main properties of the time averaged mean squared displacement and its statistical behaviour in terms of the scatter of the amplitudes between the time averages obtained from different trajectories. We especially demonstrate how anomalous dynamics may be identified for systems, which, on first sight, appear to be Brownian. Moreover, we discuss the ergodicity breaking parameters for the different anomalous stochastic processes and showcase the physical origins for the various behaviours. This Perspective is intended as a guidebook for both experimentalists and theorists working on systems, which exhibit anomalous diffusion. KW - intermittent chaotic systems KW - Fokker-Planck equations KW - time random-walks KW - fluorescence photobleaching recovery KW - fluctuation-dissipation theorem KW - fractional dynamics approach KW - photon-counting statistics KW - weak ergodicity breaking KW - flight search patterns KW - levy flights Y1 - 2014 U6 - https://doi.org/10.1039/c4cp03465a SN - 1463-9076 SN - 1463-9084 VL - 2014 IS - 16 SP - 24128 EP - 24164 ER - TY - JOUR A1 - Ehlert, Christopher A1 - Unger, Wolfgang E. S. A1 - Saalfrank, Peter T1 - C K-edge NEXAFS spectra of graphene with physical and chemical defects BT - a study based on density functional theory JF - physical chemistry, chemical physics : PCCP N2 - Recently, C K-edge Near Edge X-ray Absorption Fine Structure (NEXAFS) spectra of graphite (HOPG) surfaces have been measured for the pristine material, and for HOPG treated with either bromine or krypton plasmas (Lippitz et al., Surf. Sci., 2013, 611, L1). Changes of the NEXAFS spectra characteristic for physical (krypton) and/or chemical/physical modifications of the surface (bromine) upon plasma treatment were observed. Their molecular origin, however, remained elusive. In this work we study by density functional theory, the effects of selected point and line defects as well as chemical modifications on NEXAFS carbon K-edge spectra of single graphene layers. For Br-treated surfaces, also Br 3d X-ray Photoelectron Spectra (XPS) are simulated by a cluster approach, to identify possible chemical modifications. We observe that some of the defects related to plasma treatment lead to characteristic changes of NEXAFS spectra, similar to those in experiment. Theory provides possible microscopic origins for these changes. KW - absorbtion fine-structure KW - graphite Y1 - 2014 U6 - https://doi.org/10.1039/c4cp01106f SN - 1463-9076 SN - 1463-9084 VL - 2014 IS - 16 SP - 14083 EP - 14095 ER - TY - JOUR A1 - Pieper, Imke A1 - Wehe, Christoph A. A1 - Bornhorst, Julia A1 - Ebert, Franziska A1 - Leffers, Larissa A1 - Holtkamp, Michael A1 - Höseler, Pia A1 - Weber, Till A1 - Mangerich, Aswin A1 - Bürkle, Alexander A1 - Karst, Uwe A1 - Schwerdtle, Tanja T1 - Mechanisms of Hg species induced toxicity in cultured human astrocytes BT - genotoxicity and DNA-damage response JF - Metallomics N2 - The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organic Hg species. Mercury species investigated include MeHgCl and thiomersal. Additionally HgCl2 was studied, since in the brain mercuric Hg can be formed by dealkylation of the organic species. As a cellular system astrocytes were used. In vivo astrocytes provide the environment necessary for neuronal function. In the present study, cytotoxic effects of the respective mercuricals increased with rising alkylation level and correlated with their cellular bioavailability. Further experiments revealed for all species at subcytotoxic concentrations no induction of DNA strand breaks, whereas all species massively increased H2O2-induced DNA strand breaks. This co-genotoxic effect is likely due to a disturbance of the cellular DNA damage response. Thus, at nanomolar, sub-cytotoxic concentrations, all three mercury species strongly disturbed poly(ADP-ribosyl)ation, a signalling reaction induced by DNA strand breaks. Interestingly, the molecular mechanism behind this inhibition seems to be different for the species. Since chronic PARP-1 inhibition is also discussed to sacrifice neurogenesis and learning abilities, further experiments on neurons and in vivo studies could be helpful to clarify whether the inhibition of poly(ADP-ribosyl)ation contributes to organic Hg induced neurotoxicity. KW - cell-death KW - poly(ADP-ribose) polymerase-1 KW - neurodegenerative diseases KW - adduct formation KW - thimerosal KW - methylmercury KW - repair KW - neurotoxicity KW - manganese KW - exposure Y1 - 2014 U6 - https://doi.org/10.1039/c3mt00337j SN - 1756-591X SN - 1756-5901 VL - 2014 IS - 6 SP - 662 EP - 671 ER - TY - JOUR A1 - Meyer, Sören A1 - Matissek, M. A1 - Müller, Sandra Marie A1 - Taleshi, M. S. A1 - Ebert, Franziska A1 - Francesconi, Kevin A. A1 - Schwerdtle, Tanja T1 - In vitro toxicological characterisation of three arsenic-containing hydrocarbons JF - Metallomics N2 - Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk. KW - cod-liver KW - human-cells KW - arsenolipids present KW - excision-repair KW - fatty-acids KW - marine oils KW - RP-HPLC KW - metabolites KW - identification KW - trivalent Y1 - 2014 U6 - https://doi.org/10.1039/c4mt00061g SN - 1756-591X SN - 1756-5901 VL - 2014 IS - 6 SP - 1023 EP - 1033 ER - TY - JOUR A1 - Mondal, Suvendu Sekhar A1 - Bhunia, Asamanjoy A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Janiak, Christoph A1 - Holdt, Hans-Jürgen T1 - A supramolecular Co(II)₁₄-metal–organic cube in a hydrogen-bonded network and a Co(II)–organic framework with a flexible methoxy substituent JF - Chemical communications : ChemComm N2 - The reaction of 4,5-dicyano-2-methoxyimidazole (L1) with Co(NO3)2·6H2O under solvothermal conditions in DMF, a MOF, IFP-8 and a hydrogen-bonded network consisting of tetradecanuclear Co(II)14-metal organic cube (1) are achieved. 1 shows the bcu net with 14 cobalt atoms. KW - zinc Y1 - 2014 U6 - https://doi.org/10.1039/c3cc49698h SN - 2046-2069 VL - 2014 IS - 41 SP - 5441 EP - 5443 PB - Royal Society of Chemistry ER - TY - JOUR A1 - Cherstvy, Andrey G. A1 - Chechkin, Aleksei V. A1 - Metzler, Ralf T1 - Particle invasion, survival, and non-ergodicity in 2D diffusion processes with space-dependent diffusivity JF - Soft matter N2 - We study the thermal Markovian diffusion of tracer particles in a 2D medium with spatially varying diffusivity D(r), mimicking recently measured, heterogeneous maps of the apparent diffusion coefficient in biological cells. For this heterogeneous diffusion process (HDP) we analyse the mean squared displacement (MSD) of the tracer particles, the time averaged MSD, the spatial probability density function, and the first passage time dynamics from the cell boundary to the nucleus. Moreover we examine the non-ergodic properties of this process which are important for the correct physical interpretation of time averages of observables obtained from single particle tracking experiments. From extensive computer simulations of the 2D stochastic Langevin equation we present an in-depth study of this HDP. In particular, we find that the MSDs along the radial and azimuthal directions in a circular domain obey anomalous and Brownian scaling, respectively. We demonstrate that the time averaged MSD stays linear as a function of the lag time and the system thus reveals a weak ergodicity breaking. Our results will enable one to rationalise the diffusive motion of larger tracer particles such as viruses or submicron beads in biological cells. KW - anomalous diffusion KW - intracellular-transport KW - adenoassociated virus KW - infection pathway KW - escherichia-coli KW - endosomal escape KW - living cells KW - trafficking KW - cytoplasm KW - models Y1 - 2014 U6 - https://doi.org/10.1039/c3sm52846d SN - 2046-2069 VL - 2014 IS - 10 SP - 1591 EP - 1601 PB - Royal Society of Chemistry ER - TY - THES A1 - Schulz, Elisa T1 - The role of flavonols and anthocyanins in the cold an UV-B acclimation of Arabidopsis thaliana (L.) Y1 - 2014 ER - TY - THES A1 - Tympel, Jens Günter T1 - Numerical modeling of the Cenozoic Pamir-Tien Shan orogeny Y1 - 2014 ER - TY - JOUR A1 - Kuhlmann, Sabine A1 - Grohs, Stephan A1 - Bogumil, Jörg T1 - Reforming public administration in multilevel systems BT - an evaluation of performance changes in european local governments JF - Public administration and the modern state : assesing trends and impact Y1 - 2014 SN - 978-1-137-43748-8 SP - 205 EP - 222 PB - Palgrave CY - New York ER - TY - JOUR A1 - Fenn, Monika A1 - Brandt, Christopher Georg T1 - Time-Travel-Treasures BT - eine Mobile-Learning-App zur Erkundung des historischen Altlandsberg JF - Tür an Tür und Haus an Haus Nachbarschaften in der historischen Stadt Themenbuch 2014 Y1 - 2014 SN - 978-3-00-047888-8 SP - 76 EP - 79 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Bütow, Sascha T1 - Vielheit statt Einheit BT - Nachbarschaften in historischen Stadtkernen von Beeskow JF - Tür an Tür und Haus an Haus Nachbarschaften in der historischen Stadt Themenbuch 2014 Y1 - 2014 SN - 978-3-00-047888-8 SP - 54 EP - 57 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Heimann, Heinz-Dieter T1 - Wir alle sind Nachbarn? BT - soziale Beziehungen im Wandel der historischen Stadt und Nachbarschaften JF - Tür an Tür und Haus an Haus Nachbarschaften in der historischen Stadt Themenbuch 2014 Y1 - 2014 SN - 978-3-00-047888-8 SP - 18 EP - 23 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Heimann, Heinz-Dieter T1 - Bildungsstätten in der Stadt - Ende einer Epoche? BT - Einführung in das Kapitel - Teil 1 JF - Alte Stadt - jugendfrei?! Y1 - 2013 SN - 978-3-00-044066-3 SP - 28 EP - 31 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Fenn, Monika T1 - Heimatgefühl als Schlüssel? BT - Zwischen Identifikation und reflektiertem Umgang mit der Geschichte des Herkunfstorts JF - Alte Stadt- jugendfrei?! Y1 - 2013 SN - 978-3-00-044066-3 SP - 99 EP - 102 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Bütow, Sascha T1 - Chillen gestern BT - Orte jugendlicher Freizeitgestaltung in den historischen Stadtkernen Brandenburgs JF - Alte Stadt - jugendfrei?! Y1 - 2013 SN - 978-3-00-044066-3 SP - 75 EP - 77 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Heimann, Heinz-Dieter T1 - Von wegen Kinderspiel BT - wo steht unser Jungbrunnen? JF - Alte Stadt - jugendfrei?! Y1 - 2013 SN - 978-3-00-044066-3 SP - 17 EP - 20 PB - Arbeitsgemeinschaft Städte mit historischen Stadkernen des Landes Brandenburg CY - Potsdam ER - TY - JOUR A1 - Luksch, Tobias T1 - Friedrichs Städtebauförderung in Treuenbrietzen 1775 - 1785 JF - König macht Stadt : Preußens und andere Einflüsse auf der historischen Stadtkerne in Land Brandenburg Y1 - 2012 SN - 978-3-00-039489-8 SP - 89 EP - 96 PB - Brandenburgische Universitätsdruckerei, Verlagsgesellschaft Potsdam mbH CY - Potsdam ER - TY - JOUR A1 - Bütow, Sascha T1 - Stadtbrand und Festungsschleifung BT - wie Peitz im 18. Jahrhundert neu entstand JF - König macht Stadt : Preußens und andere Einflüsse auf der historischen Stadtkerne in Land Brandenburg Y1 - 2012 SN - 978-3-00-039489-8 SP - 79 EP - 62 PB - Brandenburgische Universitätsdruckerei, Verlagsgesellschaft Potsdam mbH CY - Potsdam ER - TY - JOUR A1 - Eichenberg, Helga A1 - Bütow, Sascha T1 - Herzog macht Stadt BT - Ansprüche und Wirklichkeiten des Städtebaus in Doberlug im 17. Jahrhundert JF - König macht Stadt : Preußens und andere Einflüsse auf der historischen Stadtkerne in Land Brandenburg Y1 - 2012 SN - 978-3-00-039489-8 SP - 57 EP - 64 PB - Brandenburgische Universitätsdruckerei, Verlagsgesellschaft Potsdam mbH CY - Potsdam ER - TY - JOUR A1 - Bütow, Sascha T1 - Vom König neu gestaltet - vom Magistrat treu verwaltet BT - Stadtumbau und Herrschaft in Beeskow wärend des 18. Jahrhunderts JF - König macht Stadt : Preußens und andere Einflüsse auf der historischen Stadtkerne in Land Brandenburg Y1 - 2012 SN - 978-3-00-039489-8 SP - 33 EP - 40 PB - Brandenburgische Universitätsdruckerei, Verlagsgesellschaft Potsdam mbH CY - Potsdam ER - TY - JOUR A1 - Heimann, Heinz-Dieter T1 - Bilder machen Geschichte BT - Unterwegs mit abweichenden Stadtgeschichten JF - König macht Stadt : Preußens und andere Einflüsse auf der historischen Stadtkerne in Land Brandenburg Y1 - 2012 SN - 978-3-00-039489-8 SP - 13 EP - 19 PB - Brandenburgische Universitätsdruckerei, Verlagsgesellschaft Potsdam mbH CY - Potsdam ER - TY - JOUR A1 - Beurskens, Rainer A1 - Mühlbauer, Thomas A1 - Granacher, Urs A1 - Gollhofer, Albert A1 - Cardinale, Marco T1 - Effects of heavy-resistance strength and balance training on unilateral and bilateral leg strength performance in old adults JF - PLoS one N2 - The term “bilateral deficit” (BLD) has been used to describe a reduction in performance during bilateral contractions when compared to the sum of identical unilateral contractions. In old age, maximal isometric force production (MIF) decreases and BLD increases indicating the need for training interventions to mitigate this impact in seniors. In a cross-sectional approach, we examined age-related differences in MIF and BLD in young (age: 20–30 years) and old adults (age: >65 years). In addition, a randomized-controlled trial was conducted to investigate training-specific effects of resistance vs. balance training on MIF and BLD of the leg extensors in old adults. Subjects were randomly assigned to resistance training (n = 19), balance training (n = 14), or a control group (n = 20). Bilateral heavy-resistance training for the lower extremities was performed for 13 weeks (3 × / week) at 80% of the one repetition maximum. Balance training was conducted using predominately unilateral exercises on wobble boards, soft mats, and uneven surfaces for the same duration. Pre- and post-tests included uni- and bilateral measurements of maximal isometric leg extension force. At baseline, young subjects outperformed older adults in uni- and bilateral MIF (all p < .001; d = 2.61–3.37) and in measures of BLD (p < .001; d = 2.04). We also found significant increases in uni- and bilateral MIF after resistance training (all p < .001, d = 1.8-5.7) and balance training (all p < .05, d = 1.3-3.2). In addition, BLD decreased following resistance (p < .001, d = 3.4) and balance training (p < .001, d = 2.6). It can be concluded that both training regimens resulted in increased MIF and decreased BLD of the leg extensors (HRT-group more than BAL-group), almost reaching the levels of young adults. Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0118535 SN - 1932-6203 PB - Public Library of Science CY - Lawrence, Kan. ER - TY - JOUR A1 - Bald, Ilko A1 - Keller, Adrian A1 - Kopyra, Janina T1 - On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy JF - RSC Advances : an international journal to further the chemical sciences N2 - Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA. KW - low-energy electrons KW - single-strand breaks KW - gas-phase KW - chemoradiation therapy KW - molecular-mechanisms KW - resonant formation KW - damage KW - attachment KW - drugs Y1 - 2014 U6 - https://doi.org/10.1039/C3RA46735J SN - 2046-2069 VL - 4 IS - 13 SP - 6825 EP - 6829 PB - Royal Society of Chemistry ER - TY - THES A1 - Secker, Christian T1 - Polypeptoid block coloymers BT - synthesis, modification, and structure formation Y1 - 2014 ER - TY - THES A1 - Schnjakin, Maxim T1 - Cloud-RAID BT - eine Methode zur Bereitstellung zuverlässiger Speicherressourcen in öffentlichen Clouds Y1 - 2014 ER - TY - THES A1 - Gerngroß, Maik T1 - Untersuchungen zur Herstellung poröser Materialien durch Acetalisierungsreaktionen Y1 - 2014 ER - TY - JOUR A1 - Görtemaker, Manfred A1 - Bienert, Michael C. A1 - Dambon, Robert T1 - Das Bundesland BT - Wiedervereinigung und Entwicklung seit 1990 JF - Brandenburg : Neues altes Land Geschichte und Gegenwart Y1 - 2010 SN - 978-3-937233-66-6 SP - 128 EP - 195 PB - be.bra wissenschaft Verlag CY - Berlin ER - TY - JOUR A1 - Bienert, Michael C. A1 - Schreckenbach, Hans-Joachim T1 - Das Land und die Bezirke BT - Brandenburg in den Jahren der SBZ/DDR (1945-1989/90) JF - Brandenburg : Neues altes Land Geschichte und Gegenwart Y1 - 2010 SN - 978-3-937233-66-6 SP - 98 EP - 127 PB - be.bra wissenschaft Verlag CY - Berlin ER - TY - JOUR A1 - Hübener, Kristina A1 - Göse, Frank T1 - Die Provinz BT - Brandenburg im 19. und frühen 20. Jahrhundert JF - Brandenburg : Neues altes Land Geschichte und Gegenwart Y1 - 2010 SN - 978-3-937233-66-6 SP - 58 EP - 97 PB - be.bra wissenschaft Verlag CY - Berlin ER - TY - JOUR A1 - Nietmann, Klaus A1 - Beck, Lorenz Friedrich A1 - Göse, Frank T1 - Die Mark BT - Brandenburg im Mittelalter und in der Frühen Neuzeit JF - Brandenburg : Neues altes Land Geschichte und Gegenwart Y1 - 2010 SN - 978-3-937233-66-6 SP - 14 EP - 57 PB - be.bra wissenschaft Verlag CY - Berlin ER - TY - BOOK ED - Beck, Lorenz Friedrich ED - Görtemaker, Manfred ED - Hübener, Kristina ED - Neitman, Klaus T1 - Brandenburg BT - Neues altes Land Geschichte und Gegenwart T3 - Brandenburgische Historische Studien ; 15 Y1 - 2010 SN - 978-3-937233-66-6 PB - be.bra wissenschaft verlag CY - Berlin ER - TY - THES A1 - Ludewig, Manuela T1 - Beendigungstatbestände als notwendige und dynamische Elemente der Mitgliedschaft in internationalen Organisationen unter besonderer Berücksichtigung von Art. 50 EUV T2 - Studien zum Öffentlichen Recht, Völker- und Europarecht ; 21 N2 - Art. 50 EUV in der Fassung des Vertrages von Lissabon normiert erstmals ein Recht für Mitgliedstaaten zum Austritt aus der EU. Manuela Ludewig stellt das Austrittsverfahren dar, diskutiert die Rechtsnatur und den Inhalt des anzustrebenden Austrittsabkommens und befasst sich mit dem Problem, ob ein (partieller) Austritt aus der Währungsunion möglich ist. Insbesondere interessiert die Autorin die Frage, ob die zur Beendigung der Mitgliedschaft in einer internationalen Organisation führenden Tatbestände einen 'notwendigen', d. h. auf die Erhaltung der Organisation, oder einen 'dynamischen', d. h. auf die bessere Realisierung des Organisationszwecks gerichteten Effekt haben können - und zwar allein aufgrund ihrer Existenz, ihrer Instrumentalisierung (Androhung) oder ihrer Verwirklichung. Y1 - 2015 SN - 978-3-631-65841-3 PB - Lang CY - Frankfurt am Main ER - TY - THES A1 - Schacht, Alexander T1 - Konzepte und Strategien mobiler Plattformen zur Erfassung und Anlayse von Vitalparametern in heterogenen Telemonotoring-Systemen Y1 - 2014 ER - TY - THES A1 - Faber, Michael T1 - Folding dynamics of RNA secondary structures BT - a structure based approach Y1 - 2014 ER - TY - BOOK A1 - Meier, Bernd A1 - Manukow, Sarkis T1 - Fachdidaktik Technik T1 - Specdidaktika techniki BT - Methoden und Prozesse des Lernens und Lehrens T3 - Schriften zu Arbeit - Beruf - Bildung ; 5 Y1 - 2011 SN - 978-3-00-033972-1 PB - Eigenverl. CY - Berlin ER -