TY - JOUR A1 - Knobloch, Jörn T1 - Die Gegenwart der Zukunft BT - zur Aktualität der sozialen Produktion von Erwartungen JF - Kultursoziologie Y1 - 2015 SN - 0941-343X VL - 2015 IS - 1 SP - 70 EP - 77 PB - Welttrends CY - Potsdam ER - TY - JOUR A1 - Heidemann, Birte T1 - Post-agreement belfast : labour, work and the new subalterns in daragh carville's play this other city JF - Reworking postcolonialism : globalization, labour and rights Y1 - 2015 SN - 978-1-137-43592-7 SP - 119 EP - 133 PB - Palgrave Macmillan CY - New York ER - TY - BOOK ED - Malreddy, Pavan Kumar ED - Heidemann, Birte ED - Larsen, Ole Birk ED - Wilson, Janet T1 - Reworking postcolonialism BT - globalization, labour and rights N2 - An interdisciplinary collection of essays, Reworking Postcolonialism explores questions of work, precarity, migration, minority and indigenous rights in relation to contemporary globalization. It focuses on the impact of global market forces on the formation of new subject positions among urban dwellers, exiles, and other disenfranchised communities. Bringing together political, economic and literary approaches to texts and events from across the postcolonial world, the essays collected here investigate the transformative effects of the global dissemination of capital and goods and the movements of people. They call for a revision of existing discourses on rights, entitlements and citizenship. Y1 - 2015 SN - 978-1-137-43592-7 PB - Palgrave Macmillan CY - New York ER - TY - THES A1 - Jacobs, Simone T1 - Biological mechanisms of the association between proportions of fatty acids in erythrocyte membranes and type 2 diabetes risk in the EPIC-Potsdam-Study Y1 - 2015 ER - TY - JOUR A1 - Shin, Jaeoh A1 - Cherstvy, Andrey G. A1 - Metzler, Ralf ED - Metzler, Ralf T1 - Kinetics of polymer looping with macromolecular crowding: effects of volume fraction and crowder size JF - Soft Matter N2 - The looping of polymers such as DNA is a fundamental process in the molecular biology of living cells, whose interior is characterised by a high degree of molecular crowding. We here investigate in detail the looping dynamics of flexible polymer chains in the presence of different degrees of crowding. From the analysis of the looping–unlooping rates and the looping probabilities of the chain ends we show that the presence of small crowders typically slows down the chain dynamics but larger crowders may in fact facilitate the looping. We rationalise these non-trivial and often counterintuitive effects of the crowder size on the looping kinetics in terms of an effective solution viscosity and standard excluded volume. It is shown that for small crowders the effect of an increased viscosity dominates, while for big crowders we argue that confinement effects (caging) prevail. The tradeoff between both trends can thus result in the impediment or facilitation of polymer looping, depending on the crowder size. We also examine how the crowding volume fraction, chain length, and the attraction strength of the contact groups of the polymer chain affect the looping kinetics and hairpin formation dynamics. Our results are relevant for DNA looping in the absence and presence of protein mediation, DNA hairpin formation, RNA folding, and the folding of polypeptide chains under biologically relevant high-crowding conditions. KW - gene-regulation kinetics KW - physiological consequences KW - spatial-organization KW - anomalous diffusion KW - folding kinetics KW - living cells KW - dna coiling KW - in-vitro KW - dynamics KW - mixtures Y1 - 2014 SN - 1744-683X SP - 472 EP - 488 PB - The Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Roder, Phillip A1 - Hille, Carsten ED - Hille, Carsten T1 - ANG-2 for quantitative Na+ determination in living cells by time-resolved fluorescence microscopy JF - Photochemical & Photobiological Sciences N2 - Sodium ions (Na+) play an important role in a plethora of cellular processes, which are complex and partly still unexplored. For the investigation of these processes and quantification of intracellular Na+ concentrations ([Na+]i), two-photon coupled fluorescence lifetime imaging microscopy (2P-FLIM) was performed in the salivary glands of the cockroach Periplaneta americana. For this, the novel Na+-sensitive fluorescent dye Asante NaTRIUM Green-2 (ANG-2) was evaluated, both in vitro and in situ. In this context, absorption coefficients, fluorescence quantum yields and 2P action cross-sections were determined for the first time. ANG-2 was 2P-excitable over a broad spectral range and displayed fluorescence in the visible spectral range. Although the fluorescence decay behaviour of ANG-2 was triexponential in vitro, its analysis indicates a Na+-sensitivity appropriate for recordings in living cells. The Na+-sensitivity was reduced in situ, but the biexponential fluorescence decay behaviour could be successfully analysed in terms of quantitative [Na+]i recordings. Thus, physiological 2P-FLIM measurements revealed a dopamine-induced [Na+]i rise in cockroach salivary gland cells, which was dependent on a Na+-K+-2Cl− cotransporter (NKCC) activity. It was concluded that ANG-2 is a promising new sodium indicator applicable for diverse biological systems. KW - cockroach salivary-glands KW - intracellular na+ KW - sodium green KW - periplaneta-americana KW - ventricular myocytes KW - lifetime microscopy KW - cytosolic sodium KW - acinar-cells KW - hela-cells KW - rat Y1 - 2014 SN - 1474-905X VL - 12 IS - 13 SP - 1699 EP - 1710 PB - The Royal Society of Chemistry CY - Cambridge ER - TY - BOOK A1 - Plattner, Hasso A1 - Leukert, Bernd T1 - The in-memory revolution BT - how sap hana enables business of the future N2 - This book describes the next generation of business applications enabled by SAP's in-memory database, SAP HANA. In particular, the authors show the substantial changes introduced in S4/HANA by switching to SAP HANA. Using numerous examples and use cases from the authors' wealth of real-world experience, it illustrates the quantum leap in performance made possible by the new technology. The book is written by two of the most prominent actors in the area of business application systems: Hasso Plattner, co-founder of SAP and inaugurator of the Hasso Plattner Institute at the University of Potsdam, and Bernd Leukert, member of the Executive Board and the Global Managing Board of SAP. This clearly structured, highly illustrated book takes an exciting new technology and presents the practicality and success of first mover applications. Y1 - 2015 SN - 978-3-319-16672-8 PB - Springer CY - Cham ER - TY - JOUR A1 - Meyer, Sören A1 - Schulz, Jacqueline A1 - Jeibmann, Astrid A1 - Taleshi, Mojtaba S. A1 - Ebert, Franziska A1 - Francesconi, Kevin A1 - Schwerdtle, Tanja ED - Schwerdtle, Tanja T1 - Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster JF - Metallomics N2 - Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood. KW - arsenolipids present KW - cod-liver KW - fatty-acids KW - identification KW - rp-hplc KW - fish KW - oil Y1 - 2014 SN - 1756-5901 SP - 2010 EP - 2014 PB - The Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Schwarze, Thomas A1 - Müller, Holger A1 - Ast, Sandra A1 - Steinbrück, Dörte A1 - Eidner, Sascha A1 - Geißler, Felix A1 - Kumke, Michael Uwe A1 - Holdt, Hans-Jürgen ED - Kumke, Michael Uwe T1 - Fluorescence lifetime-based sensing of sodium by an optode JF - Chemical Communications N2 - We report a 1,2,3-triazol fluoroionophore for detecting Na+ that shows in vitro enhancement in the Na+-induced fluorescence intensity and decay time. The Na+-selective molecule 1 was incorporated into a hydrogel as a part of a fiber optical sensor. This sensor allows the direct determination of Na+ in the range of 1–10 mM by measuring reversible fluorescence decay time changes. KW - ion optodes KW - sensors KW - indicators KW - chromoionophore KW - ionophore KW - membrane KW - switches KW - systems KW - samples KW - green Y1 - 2014 SN - 0022-4936 SN - 0009-241X SP - 14167 EP - 14170 PB - The Royal Society Chemistry CY - Cambridge ER - TY - THES A1 - Hoff, Katharina T1 - Die Nichtigkeit einer Willenserklärung nach § 105 Abs. 2 BGB - unter Berücksichtigung medizinischer Störungen N2 - Das deutsche Zivilrecht geht davon aus, dass eine erwachsene, gesunde Person ihren Willen grundsätzlich fehlerfrei bilden und äußern kann. Eine Ausnahme gilt dann, wenn sie aufgrund besonderer geistiger oder körperlicher Umstände nicht die Fähigkeit zur freien Willensbildung besitzt. Willenserklärungen von Personen, die nicht dauerhaft, sondern nur für einen vorübergehenden Moment nicht fähig sind, ihren Willen so zu äußern wie sie es unter normalen Umständen tun würden, sind nach § 105 Absatz 2 BGB nichtig. Grund dafür ist entweder eine „Bewusstlosigkeit“ oder eine „vorübergehende Störung der Geistestätigkeit“. Die sorgfältige Auslegung des Tatbestands ist wichtig für die tägliche Entscheidungspraxis der Gerichte. Die Arbeit untersucht deshalb die Vorschrift des § 105 Absatz 2 BGB im historischen, juristischen und medizinischen Kontext, berücksichtigt dabei insbesondere die Abgrenzung zur Geschäftsunfähigkeit nach § 104 Nr. 2 BGB und geht der Anwendung der Vorschrift auf konkrete medizinische Störungen (alkoholbedingte Störungen, Abhängigkeit von illegalen Drogen, Epilepsien, Demenzen, Schizophrenien, neurotische Störungen, u.a.) nach. Y1 - 2015 SN - 978-3-95404-977-6 PB - Culliver CY - Göttingen ER -