TY - JOUR A1 - Yamazaki, Yosuke A1 - Stolle, Claudia A1 - Matzka, Jürgen A1 - Siddiqui, Tarique Adnan A1 - Luehr, Hermann A1 - Alken, Patrick T1 - Longitudinal Variation of the Lunar Tide in the Equatorial Electrojet JF - Journal of geophysical research : Space physics N2 - The atmospheric lunar tide is one known source of ionospheric variability. The subject received renewed attention as recent studies found a link between stratospheric sudden warmings and amplified lunar tidal perturbations in the equatorial ionosphere. There is increasing evidence from ground observations that the lunar tidal influence on the ionosphere depends on longitude. We use magnetic field measurements from the CHAMP satellite during July 2000 to September 2010 and from the two Swarm satellites during November 2013 to February 2017 to determine, for the first time, the complete seasonal- longitudinal climatology of the semidiurnal lunar tidal variation in the equatorial electrojet intensity. Significant longitudinal variability is found in the amplitude of the lunar tidal variation, while the longitudinal variability in the phase is small. The amplitude peaks in the Peruvian sector (similar to 285 degrees E) during the Northern Hemisphere winter and equinoxes, and in the Brazilian sector (similar to 325 degrees E) during the Northern Hemisphere summer. There are also local amplitude maxima at similar to 55 degrees E and similar to 120 degrees E. The longitudinal variation is partly due to the modulation of ionospheric conductivities by the inhomogeneous geomagnetic field. Another possible cause of the longitudinal variability is neutral wind forcing by nonmigrating lunar tides. A tidal spectrum analysis of the semidiurnal lunar tidal variation in the equatorial electrojet reveals the dominance of the westward propagating mode with zonal wave number 2 (SW2), with secondary contributions by westward propagating modes with zonal wave numbers 3 (SW3) and 4 (SW4). Eastward propagating waves are largely absent from the tidal spectrum. Further study will be required for the relative importance of ionospheric conductivities and nonmigrating lunar tides. Y1 - 2017 U6 - https://doi.org/10.1002/2017JA024601 SN - 2169-9380 SN - 2169-9402 VL - 122 SP - 12445 EP - 12463 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Xu, Mei A1 - Lu, Yong-Ping A1 - Hasan, Ahmed A. A1 - Hocher, Berthold T1 - Plasma ET-1 concentrations are elevated in patients with hypertension meta-analysis of clinical studies JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. Methods: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Results: Eleven studies fulfilling our in-and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95%Ci [0.47 similar to 2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Conclusions: This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage. KW - Hypertension KW - ET-1 KW - Meta-analysis Y1 - 2017 U6 - https://doi.org/10.1159/000477572 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 2 SP - 304 EP - 313 PB - Karger CY - Basel ER - TY - JOUR A1 - Xiong, Hui A1 - Mignolet, Benoit A1 - Fang, Li A1 - Osipov, Timur A1 - Wolf, Thomas J. A. A1 - Sistrunk, Emily A1 - Gühr, Markus A1 - Remacle, Francoise A1 - Berrah, Nora T1 - The Role of Super-Atom Molecular Orbitals in Doped Fullerenes in a Femtosecond Intense Laser Field JF - Scientific reports N2 - The interaction of gas phase endohedral fullerene Ho3N@C-80 with intense (0.1-5 x 10(14) W/cm(2)), short (30 fs), 800 nm laser pulses was investigated. The power law dependence of Ho3N@C-80(q+), q = 1-2, was found to be different from that of C-60. Time-dependent density functional theory computations revealed different light-induced ionization mechanisms. Unlike in C-60, in doped fullerenes, the breaking of the cage spherical symmetry makes super atomic molecular orbital (SAMO) states optically active. Theoretical calculations suggest that the fast ionization of the SAMO states in Ho3N@C-80 is responsible for the n = 3 power law for singly charged parent molecules at intensities lower than 1.2 x 10(14) W/cm(2). Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-00124-9 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Xiang, Hai A1 - Gao, Jianqiang A1 - Cai, Dawei A1 - Luo, Yunbing A1 - Yu, Baoquan A1 - Liu, Langqing A1 - Liu, Ranran A1 - Zhou, Hui A1 - Chen, Xiaoyong A1 - Dun, Weitao A1 - Wang, Xi A1 - Hofreiter, Michael A1 - Zhao, Xingbo T1 - Origin and dispersal of early domestic pigs in northern China JF - Scientific reports N2 - It is widely accepted that modern pigs were domesticated independently at least twice, and Chinese native pigs are deemed as direct descendants of the first domesticated pigs in the corresponding domestication centers. By analyzing mitochondrial DNA sequences of an extensive sample set spanning 10,000 years, we find that the earliest pigs from the middle Yellow River region already carried the maternal lineages that are dominant in both younger archaeological populations and modern Chinese pigs. Our data set also supports early Neolithic pig utilization and a long-term in situ origin for northeastern Chinese pigs during 8,000-3,500 BP, suggesting a possibly independent domestication in northeast China. Additionally, we observe a genetic replacement in ancient northeast Chinese pigs since 3,500 BP. The results not only provide increasing evidence for pig origin in the middle Yellow River region but also depict an outline for the process of early pig domestication in northeast China. Y1 - 2017 U6 - https://doi.org/10.1038/s41598-017-06056-8 SN - 2045-2322 VL - 7 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Wyschkon, Anne A1 - Schulz, Franziska A1 - Gallit, Finja Sunnyi A1 - Poltz, Nadine A1 - Kohn-Henkel, Juliane A1 - Moraske, Svenja A1 - Bondü, Rebecca A1 - von Aster, Michael G. A1 - Esser, Günter T1 - 5-Jahres-Verlauf der LRS T1 - 5-year course of dyslexia BT - Stabilität, Geschlechtseffekte, Schriftsprachniveau und Schulerfolg BT - Persistence, sex effects, performance in reading and spelling, and school-related success JF - Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie N2 - Fragestellung: Untersucht wird der Verlauf von Kindern mit Lese-Rechtschreibstörungen (LRS) über gut 5 Jahre unter Berücksichtigung des Einflusses des Geschlechts der Betroffenen. Außerdem werden Auswirkungen der LRS auf das spätere Schriftsprachniveau und den Schulerfolg überprüft. Methodik: Eingangs wurden 995 Schüler zwischen 6 und 16 Jahren untersucht. Ein Teil dieser Kinder ist nach 43 sowie 63 Monaten nachuntersucht worden. Eine LRS wurde diagnostiziert, wenn für das Lesen bzw. Rechtschreiben das doppelte Diskrepanzkriterium von 1.5 Standardabweichungen zur nonverbalen Intelligenz und dem Mittelwert der Klassenstufe erfüllt war und gleichzeitig keine Minderbegabung vorlag. Ergebnisse: Die LRS weist über einen Zeitraum von 63 Monaten eine hohe Störungspersistenz von knapp 70 % auf. Der 5-Jahres-Verlauf der mittleren Lese- und Rechtschreibleistungen wurde nicht vom Geschlecht beeinflusst. Trotz durchschnittlicher Intelligenz blieben die LRS-Schüler in der Schriftsprache mindestens eine Standardabweichung hinter durchschnittlich und etwa 0.5 Standardabweichungseinheiten hinter unterdurchschnittlich intelligenten Kindern zurück. Der Schulerfolg der LRS-Schüler glich dem unterdurchschnittlich intelligenter Kinder und fiel deutlich schlechter aus als bei durchschnittlich intelligenten Kontrollkindern. Schlussfolgerungen: Eine LRS stellt ein erhebliches Entwicklungsrisiko dar, was frühzeitige Diagnostik- und Therapiemaßnahmen erfordert. Dafür sind reliable und im Hinblick auf die resultierenden Prävalenzraten sinnvolle, allgemein anerkannte Diagnosekriterien essenziell. N2 - Objective: The study examines the 5-year course of children with dyslexia with regard to their sex. Furthermore, the study investigates the impact of dyslexia on the performance in reading and spelling skills and school-related success. Method: A group of 995 6- to 16-year-olds were examined at the initial assessment. Part of the initial sample was then re-examined after 43 and 63 months. The diagnosis of dyslexia was based on the double discrepancy criterion using a standard deviation of 1.5. Though they had no intellectual deficits, the children showed a considerable discrepancy between their reading or writing abilities and (1) their nonverbal intelligence and (2) the mean of their grade norm. Results: Nearly 70 % of those examined had a persisting diagnosis of dyslexia over a period of 63 months. The 5-year course was not influenced by sex. Despite average intelligence, the performance in writing and spelling of children suffering from dyslexia was one standard deviation below a control group without dyslexia with average intelligence and 0.5 standard deviations below a group of children suffering from intellectual deficits. Furthermore, the school-related success of the dyslexics was significantly lower than those of children with average intelligence. Dyslexics showed similar school-related success rates to children suffering from intellectual deficits. Conclusions: Dyslexia represents a considerable developmental risk. The adverse impact of dyslexia on school-related success supports the importance of early diagnostics and intervention. It also underlines the need for reliable and general accepted diagnostic criteria. It is important to define such criteria in light of the prevalence rates. KW - dyslexia KW - discrepancy criterion KW - persistence KW - course KW - school-related success KW - Lese-Rechtschreibstörung KW - Diskreptanzdefinition KW - Stabilität KW - Verlauf KW - Schulerfolg Y1 - 2017 U6 - https://doi.org/10.1024/1422-4917/a000535 SN - 1422-4917 SN - 1664-2880 VL - 46 IS - 2 SP - 107 EP - 122 PB - Hogrefe CY - Bern ER - TY - JOUR A1 - Wyrwa, Ulrich T1 - Zum Hundertsten nichts Neues T1 - For the Hundredth nothing BT - Deutschsprachige Neuerscheinungen zum Ersten Weltkrieg (Teil III) BT - New German Language New Releases to the First World War (Part III) JF - Deutsche Zeitschrift für Geschichtswissenschaft Y1 - 2017 SN - 0044-2828 VL - 65 IS - 11 SP - 955 EP - 976 PB - Metropol-Verl. CY - Berlin ER - TY - JOUR A1 - Wurzbacher, Christian A1 - Fuchs, Andrea A1 - Attermeyer, Katrin A1 - Frindte, Katharina A1 - Grossart, Hans-Peter A1 - Hupfer, Michael A1 - Casper, Peter A1 - Monaghan, Michael T. T1 - Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment JF - Microbiome N2 - Background: Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic composition to sediment biogeochemical parameters, test whether community turnover with depth resulted from taxonomic replacement or from richness effects, and to provide a basic model for the vertical community structure in sediments. Methods: We analyzed four replicate sediment cores taken from 30-m depth in oligo-mesotrophic Lake Stechlin in northern Germany. Each 30-cm core spanned ca. 170 years of sediment accumulation according to Cs-137 dating and was sectioned into layers 1-4 cm thick. We examined a full suite of biogeochemical parameters and used DNA metabarcoding to examine community composition of microbial Archaea, Bacteria, and Eukaryota. Results: Community beta-diversity indicated nearly complete turnover within the uppermost 30 cm. We observed a pronounced shift from Eukaryota- and Bacteria-dominated upper layers (<5 cm) to Bacteria-dominated intermediate layers (5-14 cm) and to deep layers (>14 cm) dominated by enigmatic Archaea that typically occur in deep-sea sediments. Taxonomic replacement was the prevalent mechanism in structuring the community composition and was linked to parameters indicative of microbial activity (e.g., CO2 and CH4 concentration, bacterial protein production). Richness loss played a lesser role but was linked to conservative parameters (e.g., C, N, P) indicative of past conditions. Conclusions: By including all three domains, we were able to directly link the exponential decay of eukaryotes with the active sediment microbial community. The dominance of Archaea in deeper layers confirms earlier findings from marine systems and establishes freshwater sediments as a potential low-energy environment, similar to deep sea sediments. We propose a general model of sediment structure and function based on microbial characteristics and burial processes. An upper "replacement horizon" is dominated by rapid taxonomic turnover with depth, high microbial activity, and biotic interactions. A lower "depauperate horizon" is characterized by low taxonomic richness, more stable "low-energy" conditions, and a dominance of enigmatic Archaea. KW - Archaea KW - Eukaryota KW - Bacteria KW - Community KW - Freshwater KW - Lake KW - DNA metabarcoding KW - Beta-diversity KW - Sediment KW - Turnover Y1 - 2017 U6 - https://doi.org/10.1186/s40168-017-0255-9 SN - 2049-2618 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Wurzbacher, Christian A1 - Attermeyer, Katrin A1 - Kettner, Marie Therese A1 - Flintrop, Clara A1 - Warthmann, Norman A1 - Hilt, Sabine A1 - Grossart, Hans-Peter A1 - Monaghan, Michael T. T1 - DNA metabarcoding of unfractionated water samples relates phyto-, zoo- and bacterioplankton dynamics and reveals a single-taxon bacterial bloom JF - Environmental microbiology reports N2 - Most studies of aquatic plankton focus on either macroscopic or microbial communities, and on either eukaryotes or prokaryotes. This separation is primarily for methodological reasons, but can overlook potential interactions among groups. Here we tested whether DNA metabarcoding of unfractionated water samples with universal primers could be used to qualitatively and quantitatively study the temporal dynamics of the total plankton community in a shallow temperate lake. Significant changes in the relative proportions of normalized sequence reads of eukaryotic and prokaryotic plankton communities over a 3-month period in spring were found. Patterns followed the same trend as plankton estimates measured using traditional microscopic methods. The bloom of a conditionally rare bacterial taxon belonging to Arcicella was characterized, which rapidly came to dominate the whole lake ecosystem and would have remained unnoticed without metabarcoding. The data demonstrate the potential of universal DNA metabarcoding applied to unfractionated samples for providing a more holistic view of plankton communities. Y1 - 2017 U6 - https://doi.org/10.1111/1758-2229.12540 SN - 1758-2229 VL - 9 SP - 383 EP - 388 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Wurster, Sebastian A1 - Richter, Dirk A1 - Lenski, Anna Eva T1 - Teachers' use of evaluation data to improve instruction and its relationship to student achievement JF - Zeitschrift für Erziehungswissenschaft N2 - In Deutschland stehen Lehrkräften mit Ergebnissen aus Vergleichsarbeiten, zentralen Abschlussprüfungen und internen Evaluationen verschiedene Informationen zur Verfügung. Diese Daten können von ihnen dazu verwendet werden, den eigenen Unterricht zu reflektieren und weiterzuentwickeln. Die Studie geht auf Basis des IQB-Ländervergleichs 2012 den Fragen nach, ob und welche Daten von Lehrkräften zur Unterrichtsentwicklung herangezogen werden und ob datenbasierte Unterrichtsentwicklung mit Schülerleistung zusammenhängt. Die Betrachtung mehrerer Evaluationsverfahren ermöglicht eine kontrastierende Analyse und die Untersuchung einer gemeinsamen Verwendung mehrerer Informationsquellen. Die überwiegende Mehrheit der befragten Lehrkräfte berichtet, Evaluationsergebnisse als Ausgangspunkt zur Unterrichtsentwicklung zu verwenden. Allerdings zeigt sich Heterogenität zwischen einzelnen Unterrichtsentwicklungsaktivitäten und Lehrkräften. Zur Initiierung einzelner Entwicklungsaktivitäten werden auch mehrere Datenquellen simultan herangezogen. Ein direkter signifikanter Zusammenhang zwischen datenbasierter Unterrichtsentwicklung und Schülerleistung kann nicht festgestellt werden. (DIPF/Orig.). KW - Centralized examinations KW - Data-based decision making KW - Self-evaluation KW - State-wide comparison tests Y1 - 2017 U6 - https://doi.org/10.1007/s11618-017-0759-x SN - 1434-663X SN - 1862-5215 VL - 20 SP - 628 EP - 650 PB - Springer CY - Wiesbaden ER - TY - JOUR A1 - Wu, Yabin A1 - Stoddart, Martin J. A1 - Wuertz-Kozak, Karin A1 - Grad, Sibylle A1 - Alini, Mauro A1 - Ferguson, Stephen J. T1 - Hyaluronan supplementation as a mechanical regulator of cartilage tissue development under joint-kinematic-mimicking loading JF - Interface : journal of the Royal Society KW - synovial fluid KW - cartilage tissue engineering KW - mechanical loading KW - non-Newtonian fluid KW - hyaluronic acid supplementation Y1 - 2017 U6 - https://doi.org/10.1098/rsif.2017.0255 SN - 1742-5689 SN - 1742-5662 VL - 14 PB - Royal Society CY - London ER -