TY  - JOUR
A1  - Müller, Carsten
A1  - Ullmann, Kristina
A1  - Steinberg, Pablo
T1  - The grapevine-shoot extract Vineatrol30 Inhibits the chemically induced malignant transformation of BALB/c-3T3 Cells
JF  - Journal of medicinal food
N2  - Vineatrol (R) 30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3 mu g/mL significantly reduced the number of malignantly transformed foci induced by a sequential treatment of BALB/c-3T3 cells with 3-methylcholanthrene and 12-O-tetradecanoylphorbol 13-acetate in the so-called BALB/c-3T3 cell transformation assay. At a higher concentration Vineatrol30 drastically decreased the relative plating efficiency of the cells. Furthermore, the results suggest that the resveratrol oligomers present in Vineatrol30, independently from resveratrol itself, were indeed able to inhibit the formation of malignantly transformed BALB/c-3T3 foci.
KW  - BALB/c-3T3 cells
KW  - cell transformation assay
KW  - resveratrol
KW  - resveratrol oligomers
KW  - Vineatrol (R) 30
Y1  - 2011
U6  - https://doi.org/10.1089/jmf.2010.0022
SN  - 1096-620X
VL  - 14
IS  - 1-2
SP  - 34
EP  - 39
PB  - Liebert
CY  - New Rochelle
ER  - 
TY  - JOUR
A1  - Henze, Andrea
A1  - Raila, Jens
A1  - Kempf, Caroline
A1  - Reinke, Petra
A1  - Sefrin, Anett
A1  - Querfeld, Uwe
A1  - Schweigert, Florian J.
T1  - Vitamin A metabolism is changed in donors after living-kidney transplantation an observational study
JF  - Lipids in health and disease
N2  - Background: The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.
 Results: As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.
 Conclusion: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
KW  - Donors
KW  - glomerular filtration rate
KW  - kidney transplantation
KW  - retinol
KW  - retinol-binding protein 4
KW  - transthyretin
Y1  - 2011
U6  - https://doi.org/10.1186/1476-511X-10-231
SN  - 1476-511X
VL  - 10
IS  - 23
PB  - BioMed Central
CY  - London
ER  -