TY - JOUR A1 - Fuhrhop, Nanna A1 - Leubner, Martin T1 - Kafkas Sprache unter der Lupe BT - vor dem Gesetz : Texterschließung und literarische Grammatik JF - Praxis Deutsch : Kafka N2 - Die Unterrichtsanregungen zeigen exemplarisch den Nutzen von sprachlichen Zugängen im Literaturunterricht. Die Lernenden erschließen den Text Vor dem Gesetz unter Berücksichtigung des Machtgefälles zwischen den Figuren und beachten insbesondere sprachliche Mittel. Y1 - 2024 UR - https://elibrary.utb.de/doi/epdf/10.5555/pd-305-2024_11 SN - 0341-5279 VL - 51 IS - 305 SP - 55 EP - 59 PB - Friedrich CY - Hannover ER - TY - JOUR A1 - Chevalère, Johann A1 - Lazarides, Rebecca A1 - Yun, Hae Seon A1 - Henke, Anja A1 - Lazarides, Claudia A1 - Pinkwart, Niels A1 - Hafner, Verena V. T1 - Do instructional strategies considering activity emotions reduce students’ boredom in a computerized open-ended learning environment? JF - Computers and education N2 - Providing students with efficient instruction tailored to their individual characteristics in the cognitive and affective domains is an important goal in research on computer-based learning. This is especially important when seeking to enhance students' learning experience, such as by counteracting boredom, a detrimental emotion for learning. However, studies comparing instructional strategies triggered by either cognitive or emotional characteristics are surprisingly scarce. In addition, little research has examined the impact of these types of instructional strategies on performance and boredom trajectories within a lesson. In the present study, we compared the effectiveness of an intelligent tutoring system that adapted variable levels of hint details to a combination of students' dynamic, self-reported emotions and task performance (i.e., the experimental condition) to a traditional hint delivery approach consisting of a progressive, incremental supply of details following students' failures (i.e., the control condition). Linear mixed models of time-related changes in task performance and the intensity of boredom over two 1-h sessions showed that students (N = 104) in the two conditions exhibited equivalent progression in task performance and similar trajectories in boredom intensity. However, a consideration of students' achievement levels in the analyses (i.e., their final performance on the task) revealed that higher achievers in the experimental condition showed a reduction in boredom during the first session, suggesting possible benefits of using emotional information to increase the contingency of the hint delivery strategy and improve students’ learning experience. KW - intelligent tutoring system KW - Betty's brain KW - boredom KW - linear mixed models Y1 - 2023 U6 - https://doi.org/10.1016/j.compedu.2023.104741 SN - 1873-782X SN - 0360-1315 VL - 196 PB - Elsevier ER - TY - JOUR A1 - Lazarides, Rebecca A1 - Chevalère, Johann T1 - Artificial intelligence and education: Addressing the variability in learners’ emotion and motivation with adaptive teaching assistants JF - Bildung und Erziehung N2 - One of the main challenges of education in modern societies is to effectively address the variability of students in academic learning settings. Students vary in terms of their individual learning preconditions, such as achievement and preknowledge, but also motivation and emotion. Teachers, in turn, have limited resources to provide each learner with individually tailored instruction. This research overview reviews research on artificially intelligent teaching assistants and their role in providing adaptive learning opportunities in relation to learners’ heterogeneous individual learning preconditions in the field of motivation and emotion. N2 - Eine zentrale Herausforderung für Lern- und Bildungsprozesse in modernen Gesellschaften ist es, die Heterogenität von Lernenden in den Blick zu nehmen und effektiv auf ihre individuellen Bedürfnisse bei der Wissensvermittlung einzugehen. Schüler*innen unterscheiden sich in ihren individuellen Lernmerkmalen, beispielsweise in ihrer Leistungsfähigkeit, ihrem Vorwissen, aber auch in ihrer Lernmotivation und ihren lernrelevanten Emotionen. Lehrkräfte haben häufig nur limitierte Ressourcen zur Verfügung, um allen Lernenden optimal auf ihre individuellen Bedarfe zugeschnittene Lerngelegenheiten zu bieten. Der vorliegende Beitrag befasst sich vor diesem Hintergrund mit künstlich intelligenten Lernbegleitern und ihrer Bedeutung für die Entwicklung adaptiver Lerngelegenheiten, die unterschiedliche Voraussetzungen und Bedürfnisse von Lernenden im Bereich Motivation und Emotion berücksichtigen. KW - motivational-affective learning processes KW - intelligent tutoring systems KW - social robots KW - individualized instruction KW - motivational-affektive Lernentwicklung KW - intelligente tutorielle Systeme KW - Lernroboter KW - individualisiertes Unterrichten Y1 - 2021 U6 - https://doi.org/10.13109/buer.2021.74.3.264 SN - 0006-2456 SN - 2194-3834 VL - 74 IS - 3 SP - 264 EP - 279 PB - Vandenhoeck & Ruprecht ER - TY - JOUR A1 - Stieglitz, Stefan A1 - Mirbabaie, Milad A1 - Deubel, Annika A1 - Braun, Lea-Marie A1 - Kissmer, Tobias T1 - Corrigendum to “The potential of digital nudging to bridge the gap between environmental attitude and behavior in the usage of smart home applications” [International Journal of Information Management 72 (2023) 102665] JF - International journal of information management N2 - We would like to inform the readers and editors of the journal that we have discovered some errors in the references of our paper. These errors were brought to our attention by a reader who noticed some inconsistencies between the citations in the text and the bibliography. Upon further investigation, we realized that our literature management software had mistakenly linked some of the references to wrong or non-existent sources. We apologize for this oversight and assure you that it did not affect the validity or quality of our arguments and results, which were based on the correct sources. Below you find a list of the incorrect references along with their corresponding correct ones. We hope that this correction statement will clarify any confusion or misunderstanding that may have arisen from this mistake. The authors would like to apologise for any inconvenience caused. Y1 - 2024 U6 - https://doi.org/10.1016/j.ijinfomgt.2024.102774 SN - 0268-4012 SN - 1873-4707 VL - 76 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Marx, Julian A1 - Blanco, Beatriz A1 - Amaral, Adriana A1 - Stieglitz, Stefan A1 - Aquino, Maria Clara T1 - Combating misinformation with internet culture BT - the case of Brazilian public health organizations and their COVID-19 vaccination campaigns JF - Internet research N2 - Purpose This study investigates the communication behavior of public health organizations on Twitter during the COVID-19 vaccination campaign in Brazil. It contributes to the understanding of the organizational framing of health communication by showcasing several instances of framing devices that borrow from (Brazilian) internet culture. The investigation of this case extends the knowledge by providing a rich description of the organizational framing of health communication to combat misinformation in a politically charged environment. Design/methodology/approach The authors collected a Twitter dataset of 77,527 tweets and analyzed a purposeful subsample of 536 tweets that contained information provided by Brazilian public health organizations about COVID-19 vaccination campaigns. The data analysis was carried out quantitatively and qualitatively by combining social media analytics techniques and frame analysis. Findings The analysis showed that Brazilian health organizations used several framing devices that have been identified by previous literature such as hashtags, links, emojis or images. However, the analysis also unearthed hitherto unknown visual framing devices for misinformation prevention and debunking that borrow from internet culture such as “infographics,” “pop culture references” and “internet-native symbolism.” Research limitations/implications First, the identification of framing devices relating to internet culture add to our understanding of the so far little addressed framing of misinformation combat messages. The case of Brazilian health organizations provides a novel perspective to knowledge by offering a notion of internet-native symbols (e.g. humor, memes) and popular culture references for misinformation combat, including misinformation prevention. Second, this study introduces a frontier of political contextualization to misinformation research that does not relate to the partisanship of the spreaders but that relates to the political dilemmas of public organizations with a commitment to provide accurate information to citizens. Practical implications The findings inform decision-makers and public health organizations about framing devices that are tailored to internet-native audiences and can guide strategies to carry out information campaigns in misinformation-laden social media environments. Social implications The findings of this case study expose the often-overlooked cultural peculiarities of framing information campaigns on social media. The report of this study from a country in the Global South helps to contrast several assumptions and strategies that are prevalent in (health) discourses in Western societies and scholarship. Originality/value This study uncovers unconventional and barely addressed framing devices of health organizations operating in Brazil, which provides a novel perspective to the body of research on misinformation. It contributes to existing knowledge about frame analysis and broadens the understanding of frame devices borrowing from internet culture. It is a call for a frontier in misinformation research that deals with internet culture as part of organizational strategies for successful misinformation combat. KW - misinformation KW - internet culture KW - frame analysis KW - social media KW - twitter KW - global south Y1 - 2023 U6 - https://doi.org/10.1108/INTR-07-2022-0573 SN - 1066-2243 SN - 2054-5657 VL - 33 IS - 5 SP - 1990 EP - 2012 PB - Emerald CY - Bingley ER - TY - JOUR A1 - Nitzsche, Kai Nils A1 - Kleeberg, Andreas A1 - Hoffmann, Carsten A1 - Merz, Christoph A1 - Premke, Katrin A1 - Gessler, Arthur A1 - Sommer, Michael A1 - Kayler, Zachary E. T1 - Kettle holes reflect the biogeochemical characteristics of their catchment area and the intensity of the element-specific input JF - Journal of soils and sediments : protection, risk assessment and remediation N2 - Purpose Kettle holes are small inland water bodies known to be dominated by terrigenous material; however, the processes and structures that drive the enrichment and depletion of specific geochemical elements in the water column and kettle hole sediment remain unclear. We hypothesized that the mobile elements (Ca, Fe, K, P) behave different from each other in their transport, intermediate soil retention, and final accumulation in the kettle hole sediment. Methods Topsoils from transects spanning topographic positions from erosional to depositional areas, sediment cores, shallow groundwater, and kettle hole water of two glacial kettle holes in NE Germany (Rittgarten (RG) and Kraatz (KR)) were collected. The Fe, Ca, K, and total P (TP) concentrations were quantified and additionally the major anions in shallow groundwater and kettle hole water. The element-specific mobilization, relocation, and, finally, accumulation in the sediment were investigated by enrichment factors. Furthermore, a piper diagram was used to estimate groundwater flow directions and pond-internal processes. Results At KR only, the upper 10 cm of the kettle hole sediment reflected the relative element composition of the eroded terrestrial soils. The sediment from both kettle holes was enriched in Ca, Fe, K, and P compared to topsoils, indicating several possible processes including the input of clay and silt sized particles enriched in these elements, fertilizer input, and pond-internal processes including biogenic calcite and hydroxyapatite precipitation, Fe-P binding (KR), FeSx formation (RG), and elemental fixation and deposition via floating macrophytes (RG). High Ca concentrations in the kettle hole water indicated a high input of Ca from shallow groundwater inflow, while Ca precipitation in the kettle hole water led to lower Ca concentration in groundwater outflow. Conclusions The considerable element losses in the surrounding soils and the inputs into the kettle holes should be addressed by comprehensive soil and water protection measures, i.e., avoiding tillage, fertilizing conservatively, and creating buffer zones. KW - Agricultural soils KW - Soil erosion KW - Element mobility KW - Phosphorus KW - Kettle hole KW - Sediment Y1 - 2022 U6 - https://doi.org/10.1007/s11368-022-03145-8 SN - 1439-0108 SN - 1614-7480 VL - 22 IS - 3 SP - 994 EP - 1009 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Biermann, Kaija A1 - Nowak, Bianca A1 - Braun, Lea-Marie A1 - Taddicken, Monika A1 - Krämer, Nicole C. A1 - Stieglitz, Stefan T1 - Does scientific evidence sell? BT - combining manual and automated content analysis to investigate scientists’ and laypeople’s evidence practices on social media JF - Science communication N2 - Examining the dissemination of evidence on social media, we analyzed the discourse around eight visible scientists in the context of COVID-19. Using manual (N = 1,406) and automated coding (N = 42,640) on an account-based tracked Twitter/X dataset capturing scientists’ activities and eliciting reactions over six 2-week periods, we found that visible scientists’ tweets included more scientific evidence. However, public reactions contained more anecdotal evidence. Findings indicate that evidence can be a message characteristic leading to greater tweet dissemination. Implications for scientists, including explicitly incorporating scientific evidence in their communication and examining evidence in science communication research, are discussed. KW - evidence KW - public engagement KW - social media KW - COVID-19 KW - computational methods Y1 - 2024 U6 - https://doi.org/10.1177/10755470241249468 SN - 1075-5470 SN - 1552-8545 VL - 0 PB - Sage CY - Thousand Oaks, Calif. ER - TY - JOUR A1 - Garbulowski, Mateusz A1 - Smolinska, Karolina A1 - Çabuk, Uğur A1 - Yones, Sara A. A1 - Celli, Ludovica A1 - Yaz, Esma Nur A1 - Barrenas, Fredrik A1 - Diamanti, Klev A1 - Wadelius, Claes A1 - Komorowski, Jan T1 - Machine learning-based analysis of glioma grades reveals co-enrichment JF - Cancers N2 - Simple Summary Gliomas are heterogenous types of cancer, therefore the therapy should be personalized and targeted toward specific pathways. We developed a methodology that corrected strong batch effects from The Cancer Genome Atlas datasets and estimated glioma grade-specific co-enrichment mechanisms using machine learning. Our findings created hypotheses for annotations, e.g., pathways, that should be considered as therapeutic targets. Gliomas develop and grow in the brain and central nervous system. Examining glioma grading processes is valuable for improving therapeutic challenges. One of the most extensive repositories storing transcriptomics data for gliomas is The Cancer Genome Atlas (TCGA). However, such big cohorts should be processed with caution and evaluated thoroughly as they can contain batch and other effects. Furthermore, biological mechanisms of cancer contain interactions among biomarkers. Thus, we applied an interpretable machine learning approach to discover such relationships. This type of transparent learning provides not only good predictability, but also reveals co-predictive mechanisms among features. In this study, we corrected the strong and confounded batch effect in the TCGA glioma data. We further used the corrected datasets to perform comprehensive machine learning analysis applied on single-sample gene set enrichment scores using collections from the Molecular Signature Database. Furthermore, using rule-based classifiers, we displayed networks of co-enrichment related to glioma grades. Moreover, we validated our results using the external glioma cohorts. We believe that utilizing corrected glioma cohorts from TCGA may improve the application and validation of any future studies. Finally, the co-enrichment and survival analysis provided detailed explanations for glioma progression and consequently, it should support the targeted treatment. KW - glioma KW - machine learning KW - batch effect KW - TCGA KW - co-enrichment KW - rough sets Y1 - 2022 U6 - https://doi.org/10.3390/cancers14041014 SN - 2072-6694 VL - 14 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kupfer, Thomas A1 - Bauer, Evan B. A1 - van Roestel, Jan A1 - Bellm, Eric C. A1 - Bildsten, Lars A1 - Fuller, Jim A1 - Prince, Thomas A. A1 - Heber, Ulrich A1 - Geier, Stephan A1 - Green, Matthew J. A1 - Kulkarni, Shrinivas R. A1 - Bloemen, Steven A1 - Laher, Russ R. A1 - Rusholme, Ben A1 - Schneider, David T1 - Discovery of a Double-detonation Thermonuclear Supernova Progenitor JF - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters N2 - We present the discovery of a new double-detonation progenitor system consisting of a hot subdwarf B (sdB) binary with a white dwarf companion with a P (orb) = 76.34179(2) minutes orbital period. Spectroscopic observations are consistent with an sdB star during helium core burning residing on the extreme horizontal branch. Chimera light curves are dominated by ellipsoidal deformation of the sdB star and a weak eclipse of the companion white dwarf. Combining spectroscopic and light curve fits, we find a low-mass sdB star, M (sdB) = 0.383 +/- 0.028 M (circle dot) with a massive white dwarf companion, M (WD) = 0.725 +/- 0.026 M (circle dot). From the eclipses we find a blackbody temperature for the white dwarf of 26,800 K resulting in a cooling age of approximate to 25 Myr whereas our MESA model predicts an sdB age of approximate to 170 Myr. We conclude that the sdB formed first through stable mass transfer followed by a common envelope which led to the formation of the white dwarf companion approximate to 25 Myr ago. Using the MESA stellar evolutionary code we find that the sdB star will start mass transfer in approximate to 6 Myr and in approximate to 60 Myr the white dwarf will reach a total mass of 0.92 M (circle dot) with a thick helium layer of 0.17 M (circle dot). This will lead to a detonation that will likely destroy the white dwarf in a peculiar thermonuclear supernova. PTF1 J2238+7430 is only the second confirmed candidate for a double-detonation thermonuclear supernova. Using both systems we estimate that at least approximate to 1% of white dwarf thermonuclear supernovae originate from sdB+WD binaries with thick helium layers, consistent with the small number of observed peculiar thermonuclear explosions. Y1 - 2022 U6 - https://doi.org/10.3847/2041-8213/ac48f1 SN - 2041-8205 SN - 2041-8213 VL - 925 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Najman, Yani A1 - Sobel, Edward A1 - Millar, Ian A1 - Luan, Xiwu A1 - Zapata, Sebastian A1 - Garzanti, Eduardo A1 - Parra, Mauricio A1 - Vezzoli, Giovanni A1 - Zhang, Peng A1 - Wa Aung, Day A1 - Paw, Saw Mu Tha Lay A1 - Lwin, Thae Naung T1 - The timing of collision between Asia and the West Burma Terrane, and the development of the Indo-Burman Ranges JF - Tectonics N2 - The West Burma Terrane (WBT) is a small terrane bounded to the east by the Asian Sibumasu Block and to the west by the Indo-Burman Ranges (IBR), the latter being an exhumed accretionary prism that formed during subduction of Indian oceanic lithosphere beneath Asia. Understanding the geological history of the WBT is important for reconstruction of the closure history of the Tethys Ocean and India-Asia collision. Currently there are major discrepancies in the proposed timings of collision between the WBT with both India and Asia; whether the WBT collided with India or Asia first is debated, and proposed timings of collisions stretch from the Mesozoic to the Cenozoic. We undertook a multi-technique provenance study involving petrography, detrital zircon U-Pb and Hf analyses, rutile U-Pb analyses and Sr-Nd bulk rock analyses on sediments of the Central Myanmar Basins of the WBT. We determined that the first arrival of Asian material into the basin occurred after the earliest late Eocene and by the early Oligocene, thus placing a minimum constraint on the timing of WBT-Asia collision. Our low temperature thermochronological study of the IBR records two periods of exhumation, in the early-middle Eocene, and at the Oligo-Miocene boundary. The Eocene event may be associated with the collision of the WBT with India. The later event at the Oligo-Miocene boundary may be associated with changes in wedge dynamics resulting from increased sediment supply to the system; however a number of other possible causes provide equally plausible explanations for both events. KW - Central Myanmar Basin KW - Indo-Burman Ranges KW - low temperature thermochronology KW - detrital provenance KW - West Burma Terrane Y1 - 2022 U6 - https://doi.org/10.1029/2021TC007057 SN - 0278-7407 SN - 1944-9194 VL - 41 IS - 7 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Jebabli, Nidhal A1 - Zouhal, Hassane A1 - Boullosa, Daniel A1 - Govindasamy, Karuppasamy A1 - Tourny, Claire A1 - Hackney, Anthony C. A1 - Granacher, Urs A1 - Ben Abderrahman, Abderraouf T1 - The effects of preferred music and its timing on performance, pacing, and psychophysiological responses during the 6-min test JF - Journal of human kinetics N2 - The aim of this study was to investigate the effects of listening to preferred music during a warm up or exercise, on performance during a 6-min all-out exercise test (6-MT) in young adult males. Twenty-five healthy males volunteered to participate in this study. Following a within subject design, participants performed three test conditions (MDT: music during the test; MDW: music during the warm-up; WM: without music) in random order. Outcomes included mean running speed over the 6-min test (MRS6), total distance covered (TDC), heart rate responses (HRpeak, HRmean), blood lactate (3-min after the test), and the rating of perceived exertion (RPE); additionally, feeling scale scores were recorded. Listening to preferred music during running resulted in significant TDC (Delta up arrow 10%, p=0.006, ES=0.80) and MRS6 (Delta up arrow 14%, p=0.012, ES=1.02) improvement during the 6-MT, improvement was also noted for the warm-up with music condition (TDC:Delta up arrow 8%, p=0.028, ES=0.63; MRS6:Delta up arrow 8%, p=0.032, ES=0.61). A similar reverse "J-shaped" pacing profile was detected during the three conditions. Blood lactate was lower in the MDT condition by 8% (p=0.01, ES=1.10), but not the MDW condition, compared to MW. In addition, no statistically significant differences were found between the test sessions for the HR, RPE, and feeling scale scores. In conclusion, listening to music during exercise testing would be more beneficial for optimal TDC and MRS6 performances compared to MDW and WM. KW - rating of perceived exertion KW - work-rate distribution KW - blood lactate; KW - aerobic exercise Y1 - 2022 U6 - https://doi.org/10.2478/hukin-2022-0038 SN - 1640-5544 SN - 1899-7562 VL - 82 IS - 1 SP - 123 EP - 133 PB - Academy of Physical Education CY - Katowice ER - TY - JOUR A1 - Agarwal, Saloni A1 - Hamidizadeh, Mojdeh A1 - Bier, Frank Fabian T1 - Detection of reverse transcriptase LAMP-amplified nucleic acid from oropharyngeal viral swab samples using biotinylated DNA probes through a lateral flow assay JF - Biosensors : open access journal N2 - This study focuses on three key aspects: (a) crude throat swab samples in a viral transport medium (VTM) as templates for RT-LAMP reactions; (b) a biotinylated DNA probe with enhanced specificity for LFA readouts; and (c) a digital semi-quantification of LFA readouts. Throat swab samples from SARS-CoV-2 positive and negative patients were used in their crude (no cleaning or pre-treatment) forms for the RT-LAMP reaction. The samples were heat-inactivated but not treated for any kind of nucleic acid extraction or purification. The RT-LAMP (20 min processing time) product was read out by an LFA approach using two labels: FITC and biotin. FITC was enzymatically incorporated into the RT-LAMP amplicon with the LF-LAMP primer, and biotin was introduced using biotinylated DNA probes, specifically for the amplicon region after RT-LAMP amplification. This assay setup with biotinylated DNA probe-based LFA readouts of the RT-LAMP amplicon was 98.11% sensitive and 96.15% specific. The LFA result was further analysed by a smartphone-based IVD device, wherein the T-line intensity was recorded. The LFA T-line intensity was then correlated with the qRT-PCR Ct value of the positive swab samples. A digital semi-quantification of RT-LAMP-LFA was reported with a correlation coefficient of R2 = 0.702. The overall RT-LAMP-LFA assay time was recorded to be 35 min with a LoD of three RNA copies/µL (Ct-33). With these three advancements, the nucleic acid testing-point of care technique (NAT-POCT) is exemplified as a versatile biosensor platform with great potential and applicability for the detection of pathogens without the need for sample storage, transportation, or pre-processing. KW - RT-LAMP KW - LFA KW - NAAT-LFA KW - semi-quantitative KW - surveillance-based diagnostics Y1 - 2023 U6 - https://doi.org/10.3390/bios13110988 SN - 2079-6374 VL - 13 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Numberger, Daniela A1 - Zoccarato, Luca A1 - Woodhouse, Jason Nicholas A1 - Ganzert, Lars A1 - Sauer, Sascha A1 - García Márquez, Jaime Ricardo A1 - Domisch, Sami A1 - Grossart, Hans-Peter A1 - Greenwood, Alex T1 - Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man N2 - Freshwater ecosystems are characterized by complex and highly dynamic microbial communities that are strongly structured by their local environment and biota. Accelerating urbanization and growing city populations detrimentally alter freshwater environments. To determine differences in freshwater microbial communities associated with urban-ization, full-length 16S rRNA gene PacBio sequencing was performed in a case study from surface waters and sedi-ments from a wastewater treatment plant, urban and rural lakes in the Berlin-Brandenburg region, Northeast Germany. Water samples exhibited highly habitat specific bacterial communities with multiple genera showing clear urban signatures. We identified potentially harmful bacterial groups associated with environmental parameters specific to urban habitats such as Alistipes, Escherichia/Shigella, Rickettsia and Streptococcus. We demonstrate that urban-ization alters natural microbial communities in lakes and, via simultaneous warming and eutrophication and creates favourable conditions that promote specific bacterial genera including potential pathogens. Our findings are evidence to suggest an increased potential for long-term health risk in urbanized waterbodies, at a time of rapidly expanding global urbanization. The results highlight the urgency for undertaking mitigation measures such as targeted lake restoration projects and sustainable water management efforts. KW - Urbanization KW - Urban waters KW - Wastewater KW - Lakes KW - Microbial community KW - composition KW - Humanization KW - Full-length 16S rRNA PacBio sequencing Y1 - 2022 U6 - https://doi.org/10.1016/j.scitotenv.2022.157321 SN - 0048-9697 SN - 1879-1026 VL - 845 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zavorka, Libor A1 - Blanco, Andreu A1 - Chaguaceda, Fernando A1 - Cucherousset, Julien A1 - Killen, Shaun S. A1 - Lienart, Camilla A1 - Mathieu-Resuge, Margaux A1 - Nemec, Pavel A1 - Pilecky, Matthias A1 - Scharnweber, Inga Kristin A1 - Twining, Cornelia W. A1 - Kainz, Martin J. T1 - The role of vital dietary biomolecules in eco-evo-devo dynamics JF - Trends in ecology and evolution N2 - The physiological dependence of animals on dietary intake of vitamins, amino acids, and fatty acids is ubiquitous. Sharp differences in the availability of these vital dietary biomolecules among different resources mean that consumers must adopt a range of strategies to meet their physiological needs. We review the emerging work on omega-3 long-chain polyunsaturated fatty acids, focusing predominantly on predator-prey interactions, to illustrate that trade-off between capacities to consume resources rich in vital biomolecules and internal synthesis capacity drives differences in phenotype and fitness of consumers. This can then feedback to impact ecosystem functioning. We outline how focus on vital dietary biomolecules in eco-eco-devo dynamics can improve our understanding of anthropogenic changes across multiple levels of biological organization. Y1 - 2023 U6 - https://doi.org/10.1016/j.tree.2022.08.010 SN - 0169-5347 SN - 1872-8383 VL - 38 IS - 1 SP - 72 EP - 84 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Jaiser, Ralf A1 - Akperov, Mirseid A1 - Timazhev, A. A1 - Romanowsky, Erik A1 - Handorf, Dörthe A1 - Mokhov, I. I. T1 - Linkages between arctic and mid-latitude weather and climate BT - unraveling the impact of changing sea ice and sea surface temperatures during Winter JF - Meteorologische Zeitschrift N2 - The study addresses the question, if observed changes in terms of Arctic-midlatitude linkages during winter are driven by Arctic Sea ice decline alone or if the increase of global sea surface temperatures plays an additional role. We compare atmosphere-only model experiments with ECHAM6 to ERA-Interim Reanalysis data. The model sensitivity experiment is implemented as a set of four combinations of sea ice and sea surface temperature boundary conditions. Atmospheric circulation regimes are determined and evaluated in terms of their cyclone and blocking characteristics and changes in frequency during winter. As a prerequisite, ECHAM6 reproduces general features of circulation regimes very well. Tropospheric changes induced by the change of boundary conditions are revealed and further impacts on the large-scale circulation up into the stratosphere are investigated. In early winter, the observed increase of atmospheric blocking in the region between Scandinavia and the Urals are primarily related to the changes in sea surface temperatures. During late winter, we f nd a weakened polar stratospheric vortex in the reanalysis that further impacts the troposphere. In the model sensitivity study a climatologically weakened polar vortex occurs only if sea ice is reduced and sea surface temperatures are increased together. This response is delayed compared to the reanalysis. The tropospheric response during late winter is inconclusive in the model, which is potentially related to the weak and delayed response in the stratosphere. The model experiments do not reproduce the connection between early and late winter as interpreted from the reanalysis. Potentially explaining this mismatch, we identify a discrepancy of ECHAM6 to reproduce the weakening of the stratospheric polar vortex through blocking induced upward propagation of planetary waves. KW - Weather regimes KW - Blocking KW - Cyclones KW - Wave Propagation KW - Stratosphere Y1 - 2023 U6 - https://doi.org/10.1127/metz/2023/1154 SN - 0941-2948 SN - 1610-1227 VL - 32 IS - 3 SP - 173 EP - 194 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Gerlach, Moritz A1 - Glück, Jochen A1 - Kunze, Markus T1 - Stability of transition semigroups and applications to parabolic equations JF - Transactions of the American Mathematical Society N2 - This paper deals with the long-term behavior of positive operator semigroups on spaces of bounded functions and of signed measures, which have applications to parabolic equations with unbounded coefficients and to stochas-tic analysis. The main results are a Tauberian type theorem characterizing the convergence to equilibrium of strongly Feller semigroups and a generalization of a classical convergence theorem of Doob. None of these results requires any kind of time regularity of the semigroup. KW - Transition probabilities KW - strong Feller property KW - asymptotic KW - behavior KW - invariant measure KW - parabolic equations Y1 - 2023 U6 - https://doi.org/10.1090/tran/8620 SN - 0002-9947 SN - 1088-6850 VL - 376 IS - 1 SP - 153 EP - 180 PB - American Mathematical Soc. CY - Providence ER - TY - JOUR A1 - Schwetlick, Lisa A1 - Backhaus, Daniel A1 - Engbert, Ralf T1 - A dynamical scan-path model for task-dependence during scene viewing JF - Psychological review N2 - In real-world scene perception, human observers generate sequences of fixations to move image patches into the high-acuity center of the visual field. Models of visual attention developed over the last 25 years aim to predict two-dimensional probabilities of gaze positions for a given image via saliency maps. Recently, progress has been made on models for the generation of scan paths under the constraints of saliency as well as attentional and oculomotor restrictions. Experimental research demonstrated that task constraints can have a strong impact on viewing behavior. Here, we propose a scan-path model for both fixation positions and fixation durations, which include influences of task instructions and interindividual differences. Based on an eye-movement experiment with four different task conditions, we estimated model parameters for each individual observer and task condition using a fully Bayesian dynamical modeling framework using a joint spatial-temporal likelihood approach with sequential estimation. Resulting parameter values demonstrate that model properties such as the attentional span are adjusted to task requirements. Posterior predictive checks indicate that our dynamical model can reproduce task differences in scan-path statistics across individual observers. KW - scene viewing KW - eye movements KW - task dependence KW - individual differences; KW - Bayesian inference Y1 - 2023 U6 - https://doi.org/10.1037/rev0000379 SN - 0033-295X SN - 1939-1471 VL - 130 IS - 3 SP - 807 EP - 840 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Botteri, Edoardo A1 - Peveri, Giulia A1 - Berstad, Paula A1 - Bagnardi, Vincenzo A1 - Chen, Sairah L. F. A1 - Sandanger, Torkjel M. A1 - Hoff, Geir A1 - Dahm, Christina C. A1 - Antoniussen, Christian S. A1 - Tjonneland, Anne A1 - Eriksen, Anne Kirstine A1 - Skeie, Guri A1 - Perez-Cornago, Aurora A1 - Huerta, Jose Maria A1 - Jakszyn, Paula A1 - Harlid, Sophia A1 - Sundstroem, Bjoern A1 - Barricarte, Aurelio A1 - Monninkhof, Evelyn M. A1 - Derksen, Jeroen W. G. A1 - Schulze, Matthias Bernd A1 - Bueno-de-Mesquita, Bas A1 - Sanchez, Maria-Jose A1 - Cross, Amanda J. A1 - Tsilidis, Konstantinos K. A1 - De Magistris, Maria Santucci A1 - Kaaks, Rudolf A1 - Katzke, Verena A1 - Rothwell, Joseph A. A1 - Laouali, Nasser A1 - Severi, Gianluca A1 - Amiano, Pilar A1 - Contiero, Paolo A1 - Sacerdote, Carlotta A1 - Goldberg, Marcel A1 - Touvier, Mathilde A1 - Freisling, Heinz A1 - Viallon, Vivian A1 - Weiderpass, Elisabete A1 - Riboli, Elio A1 - Gunter, Marc J. A1 - Jenab, Mazda A1 - Ferrari, Pietro T1 - Changes in lifestyle and risk of colorectal cancer in the European prospective investigation into cancer and nutrition JF - The American journal of gastroenterology : AJG N2 - INTRODUCTION: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. METHODS: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI). RESULTS: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI <= 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile. DISCUSSION: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention. Y1 - 2022 U6 - https://doi.org/10.14309/ajg.0000000000002065 SN - 0002-9270 SN - 1572-0241 VL - 118 IS - 4 SP - 702 EP - 711 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Di Bello, Costantino A1 - Hartmann, Alexander K. A1 - Majumdar, Satya N. A1 - Mori, Francesco A1 - Rosso, Alberto A1 - Schehr, Gregory T1 - Current fluctuations in stochastically resetting particle systems JF - Physical review : E, Statistical, nonlinear and soft matter physics N2 - We consider a system of noninteracting particles on a line with initial positions distributed uniformly with density ? on the negative half-line. We consider two different models: (i) Each particle performs independent Brownian motion with stochastic resetting to its initial position with rate r and (ii) each particle performs run -and-tumble motion, and with rate r its position gets reset to its initial value and simultaneously its velocity gets randomized. We study the effects of resetting on the distribution P(Q, t) of the integrated particle current Q up to time t through the origin (from left to right). We study both the annealed and the quenched current distributions and in both cases, we find that resetting induces a stationary limiting distribution of the current at long times. However, we show that the approach to the stationary state of the current distribution in the annealed and the quenched cases are drastically different for both models. In the annealed case, the whole distribution P-an(Q, t) approaches its stationary limit uniformly for all Q. In contrast, the quenched distribution P-qu(Q, t) attains its stationary form for Q < Q(crit)(t), while it remains time dependent for Q > Q(crit)(t). We show that Q(crit)(t) increases linearly with t for large t. On the scale where Q <; Q(crit)(t), we show that P-qu(Q, t) has an unusual large deviation form with a rate function that has a third-order phase transition at the critical point. We have computed the associated rate functions analytically for both models. Using an importance sampling method that allows to probe probabilities as tiny as 10-14000, we were able to compute numerically this nonanalytic rate function for the resetting Brownian dynamics and found excellent agreement with our analytical prediction. Y1 - 2023 U6 - https://doi.org/10.1103/PhysRevE.108.014112 SN - 2470-0045 SN - 2470-0053 VL - 108 IS - 1 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Grdseloff, Nastasja A1 - Boulday, Gwenola A1 - Roedel, Claudia J. A1 - Otten, Cecile A1 - Vannier, Daphne Raphaelle A1 - Cardoso, Cecile A1 - Faurobert, Eva A1 - Dogra, Deepika A1 - Tournier-Lasserve, Elisabeth A1 - Abdelilah-Seyfried, Salim T1 - Impaired retinoic acid signaling in cerebral cavernous malformations JF - Scientific reports N2 - The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells. Mutations of CCM genes within the brain vasculature can lead to recurrent cerebral hemorrhages. Pharmacological treatment options are urgently needed when lesions are located in deeply-seated and in-operable regions of the central nervous system. Previous pharmacological suppression screens in disease models of CCM led to the discovery that treatment with retinoic acid improved CCM phenotypes. This finding raised a need to investigate the involvement of retinoic acid in CCM and test whether it has a curative effect in preclinical mouse models. Here, we show that components of the retinoic acid synthesis and degradation pathway are transcriptionally misregulated across disease models of CCM. We complemented this analysis by pharmacologically modifying retinoic acid levels in zebrafish and human endothelial cell models of CCM, and in acute and chronic mouse models of CCM. Our pharmacological intervention studies in CCM2-depleted human umbilical vein endothelial cells (HUVECs) and krit1 mutant zebrafish showed positive effects when retinoic acid levels were increased. However, therapeutic approaches to prevent the development of vascular lesions in adult chronic murine models of CCM were drug regiment-sensitive, possibly due to adverse developmental effects of this hormone. A treatment with high doses of retinoic acid even worsened CCM lesions in an adult chronic murine model of CCM. This study provides evidence that retinoic acid signaling is impaired in the CCM pathophysiology and suggests that modification of retinoic acid levels can alleviate CCM phenotypes. KW - Developmental biology KW - Molecular medicine Y1 - 2023 U6 - https://doi.org/10.1038/s41598-023-31905-0 SN - 2045-2322 VL - 13 IS - 1 PB - Nature Portfolio CY - Berlin ER -