TY - CHAP A1 - Arlt, Olga A1 - Schwiebs, Anja A1 - Pfarr, Kathrin A1 - Ranglack, Annika A1 - Bouzas, Ferreiros Nerea A1 - Schreiber, Yannick A1 - Neuber, Corinna A1 - Kleuser, Burkhard A1 - Pfeilschifter, Josef M. A1 - Radeke, Heinfried H. T1 - Dynamic interaction between sphingolipid enzymes, S1P and inflammatory cytokine regulation in dendritic cells T2 - NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Y1 - 2014 SN - 0028-1298 SN - 1432-1912 VL - 387 SP - S91 EP - S91 PB - Springer CY - New York ER - TY - CHAP A1 - Hiort, Pauline A1 - Hugo, Julian A1 - Zeinert, Justus A1 - Müller, Nataniel A1 - Kashyap, Spoorthi A1 - Rajapakse, Jagath C. A1 - Azuaje, Francisco A1 - Renard, Bernhard Y. A1 - Baum, Katharina T1 - DrDimont: explainable drug response prediction from differential analysis of multi-omics networks T2 - Bioinformatics N2 - Motivation: While it has been well established that drugs affect and help patients differently, personalized drug response predictions remain challenging. Solutions based on single omics measurements have been proposed, and networks provide means to incorporate molecular interactions into reasoning. However, how to integrate the wealth of information contained in multiple omics layers still poses a complex problem. Results: We present DrDimont, Drug response prediction from Differential analysis of multi-omics networks. It allows for comparative conclusions between two conditions and translates them into differential drug response predictions. DrDimont focuses on molecular interactions. It establishes condition-specific networks from correlation within an omics layer that are then reduced and combined into heterogeneous, multi-omics molecular networks. A novel semi-local, path-based integration step ensures integrative conclusions. Differential predictions are derived from comparing the condition-specific integrated networks. DrDimont's predictions are explainable, i.e. molecular differences that are the source of high differential drug scores can be retrieved. We predict differential drug response in breast cancer using transcriptomics, proteomics, phosphosite and metabolomics measurements and contrast estrogen receptor positive and receptor negative patients. DrDimont performs better than drug prediction based on differential protein expression or PageRank when evaluating it on ground truth data from cancer cell lines. We find proteomic and phosphosite layers to carry most information for distinguishing drug response. Y1 - 2022 U6 - https://doi.org/10.1093/bioinformatics/btac477 SN - 1367-4803 SN - 1367-4811 VL - 38 SP - ii113 EP - ii119 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Sharkovska, Y. A1 - Alter, Markus L. A1 - Reichetzeder, Christoph A1 - Tsuprykov, Oleg A1 - Klein, T. A1 - Hocher, Berthold T1 - DPP-4 inhibition with linagliptin delays the progression of diabetic nephropathy in db/db mice T2 - Diabetologia : journal of the European Association for the Study of Diabetes (EASD) Y1 - 2012 SN - 0012-186X SN - 1432-0428 VL - 55 IS - 5 SP - S20 EP - S20 PB - Springer CY - New York ER - TY - CHAP A1 - Wernicke, Sarah A1 - Carlsohn, Anja A1 - Heydenreich, Juliane A1 - Mayer, Frank T1 - Does the copenhagen soccer test induce a repeated bout effect? - a pilot study T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2013 SN - 0195-9131 SN - 1530-0315 VL - 45 IS - 5 SP - 169 EP - 169 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Appiah-Dwomoh, Edem Korkor A1 - Torlak, Firdevs A1 - Engel, Tilman A1 - Stoll, Josefine A1 - Müller, Juliane A1 - Mayer, Frank T1 - Does perturbed treadmill walking lead to emg-changes of the lower extremity? T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2014 SN - 0195-9131 SN - 1530-0315 VL - 46 IS - 5 SP - 827 EP - 827 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Nowozin, Claudia A1 - Wahnschaffe, A. A1 - Fay, Doris A1 - Pollatos, Olga A1 - Kunz, D. T1 - Does bright light interfere with fear learning? T2 - Journal of sleep research : official journal of the European Sleep Research Society Y1 - 2014 SN - 0962-1105 SN - 1365-2869 VL - 23 SP - 102 EP - 102 PB - Wiley-Blackwell CY - Hoboken ER - TY - CHAP A1 - Abramova, Olga T1 - Does a smile open all doors? BT - understanding the impact of appearance disclosure on accommodation sharing platforms T2 - Proceedings of the 53rd Hawaii International Conference on System Sciences N2 - Online photographs govern an individual’s choices across a variety of contexts. In sharing arrangements, facial appearance has been shown to affect the desire to collaborate, interest to explore a listing, and even willingness to pay for a stay. Because of the ubiquity of online images and their influence on social attitudes, it seems crucial to be able to control these aspects. The present study examines the effect of different photographic self-disclosures on the provider’s perceptions and willingness to accept a potential co-sharer. The findings from our experiment in the accommodation-sharing context suggest social attraction mediates the effect of photographic self-disclosures on willingness to host. Implications of the results for IS research and practitioners are discussed. KW - The Sharing Economy KW - airbnb KW - online photographs KW - self-disclosure KW - sharing economy KW - social attraction Y1 - 2020 SN - 978-0-9981331-3-3 SP - 831 EP - 840 PB - HICSS Conference Office University of Hawaii at Manoa CY - Honolulu ER - TY - CHAP A1 - Höchenberger, Ralf A1 - Hummel, Detlev A1 - Seitz, Jürgen ED - Sharma, Neha ED - Goje, Amol ED - Chakrabarti, Amlan ED - Bruckstein, Alfred M. T1 - Do women shy away from cryptocurrency investment? BT - cross-country evidence from survey data T2 - Data management, analytics and innovation N2 - This study utilizes cross-country survey data to analyze differences in attitudes toward cryptocurrency as an alternative to traditional money issued by a central bank. Particularly, we investigate women’s general attitude toward cryptocurrency systems. Results suggest that women invest less into cryptocurrency, show less interest in the future cryptocurrency investment, and see less economic potential in these systems than men do. Further evidence shows that these attitudes are directly connected with lower literacy in cryptocurrency systems. These findings support theory on gender differences in investment behavior. We contribute to the existing literature by conducting a cross-country survey on cryptocurrency attitudes in Europe and Asia, and hence show that this gender effect is robust across these cultures. KW - cryptocurrencies KW - bitcoin KW - financial literacy KW - gender gap KW - risk tolerance Y1 - 2023 SN - 978-981-99-1413-5 SN - 978-981-99-1414-2 U6 - https://doi.org/10.1007/978-981-99-1414-2_6 SP - 69 EP - 76 PB - Springer Nature CY - Singapore ER - TY - CHAP A1 - Gruber, W. A1 - Braumann, K. M. A1 - Kahlert, Daniela A1 - Brand, Ralf A1 - Schwarz, C. A1 - Staab, D. T1 - Do interavenous antibiotic therapies increase level of physical activity in CF? T2 - Pediatric pulmonology Y1 - 2011 SN - 8755-6863 IS - 3 SP - 355 EP - 355 PB - Wiley-Blackwell CY - Malden ER - TY - CHAP A1 - Doyon, Anke A1 - Schmiedchen, Bettina A1 - Bayazit, Aysun A1 - Canpolat, Nur A1 - Duzova, Ali A1 - Kracht, Daniela A1 - Litwin, Mieczyslaw A1 - Niemirska, Anna A1 - Sozeri, Betul A1 - Zeller, Rene A1 - Ranchin, Bruno A1 - Anarat, Ali A1 - Caliskan, Salim A1 - Mir, Sevgi A1 - Melk, Anette A1 - Wühl, Elke A1 - Schweigert, Florian J. A1 - Querfeld, Uwe A1 - Schäfer, Franz T1 - Distribuion and determinants of serum vitamin d concentrations in european children with chronic kidney disease T2 - Pediatric nephrology : journal of the International Pediatric Nephrology Association Y1 - 2012 SN - 0931-041X VL - 27 IS - 9 SP - 1627 EP - 1628 PB - Springer CY - New York ER - TY - CHAP A1 - Hocher, Berthold A1 - Reichetzeder, Christoph A1 - von Websky, Karoline A1 - Tsuprykov, Oleg A1 - Klein, T. T1 - Dipeptidyl peptidase-4 inhibition in a rat model of ischaemia-reperfusion injury may accelerate tubular regeneration but does not improve glomerular filtration rate T2 - Diabetologia : journal of the European Association for the Study of Diabetes (EASD) Y1 - 2014 SN - 0012-186X SN - 1432-0428 VL - 57 SP - S538 EP - S538 PB - Springer CY - New York ER - TY - CHAP A1 - Rojahn, Marcel A1 - Gronau, Norbert T1 - Digital platform concepts for manufacturing companies BT - a review T2 - 10th International Conference on Future Internet of Things and Cloud (FiCloud) N2 - Digital Platforms (DPs) has established themself in recent years as a central concept of the Information Technology Science. Due to the great diversity of digital platform concepts, clear definitions are still required. Furthermore, DPs are subject to dynamic changes from internal and external factors, which pose challenges for digital platform operators, developers and customers. Which current digital platform research directions should be taken to address these challenges remains open so far. The following paper aims to contribute to this by outlining a systematic literature review (SLR) on digital platform concepts in the context of the Industrial Internet of Things (IIoT) for manufacturing companies and provides a basis for (1) a selection of definitions of current digital platform and ecosystem concepts and (2) a selection of current digital platform research directions. These directions are diverted into (a) occurrence of digital platforms, (b) emergence of digital platforms, (c) evaluation of digital platforms, (d) development of digital platforms, and (e) selection of digital platforms. Y1 - 2023 SN - 979-8-3503-1635-3 U6 - https://doi.org/10.1109/FiCloud58648.2023.00030 SP - 149 EP - 158 PB - IEEE CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Marx, Julian A1 - Brünker, Felix A1 - Mirbabaie, Milad A1 - Stieglitz, Stefan ED - Bui, Tung X. T1 - Digital activism on social media BT - the role of brand ambassadors and corporate reputation management T2 - Proceedings of the 57th Annual Hawaii International Conference on System Sciences N2 - Social media constitute an important arena for public debates and steady interchange of issues relevant to society. To boost their reputation, commercial organizations also engage in political, social, or environmental debates on social media. To engage in this type of digital activism, organizations increasingly utilize the social media profiles of executive employees and other brand ambassadors. However, the relationship between brand ambassadors’ digital activism and corporate reputation is only vaguely understood. The results of a qualitative inquiry suggest that digital activism via brand ambassadors can be risky (e.g., creating additional surface for firestorms, financial loss) and rewarding (e.g., emitting authenticity, employing ‘megaphones’ for industry change) at the same time. The paper informs both scholarship and practitioners about strategic trade-offs that need to be considered when employing brand ambassadors for digital activism. KW - the bright and dark side of social media in the marginalized contexts KW - brand ambassadors KW - digital activism KW - reputation management KW - social media Y1 - 2024 UR - https://hdl.handle.net/10125/107250 SN - 978-0-99813-317-1 SP - 7205 EP - 7214 PB - Department of IT Management Shidler College of Business University of Hawaii CY - Honolulu, HI ER - TY - CHAP A1 - Lausberg, H. A1 - Kazzer, Philipp A1 - Heekeren, Hauke A1 - Wartenburger, Isabell T1 - Differential cortical mechanisms underlying tool use, pantomime, and body-part-as-object use T2 - European journal of neurology : the official journal of the European Federation of Neurological Societies Y1 - 2012 SN - 1351-5101 VL - 19 IS - 9 SP - 78 EP - 78 PB - Wiley-Blackwell CY - Hoboken ER - TY - CHAP A1 - Otto, Christoph A1 - Scharhag-Rosenberger, Friederike A1 - Carlsohn, Anja A1 - Scharhag, Jürgen A1 - Mayer, Frank T1 - Differences in using the same supramaximal verification test protocol for treadmill and cycle ergometry T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2012 SN - 0195-9131 VL - 44 SP - 295 EP - 295 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Carlsohn, Anja A1 - Weber, Josefine A1 - Müller, Juliane A1 - Stuwe, Anja A1 - Müller, Steffen A1 - Mayer, Frank T1 - Dietary intake to reduce body mass before competition in german judo athletes T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2012 SN - 0195-9131 VL - 44 SP - 109 EP - 109 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Richter, M. A1 - Fairhall, Emma A. A1 - Hoffmann, S. A. A1 - Frühwald, J. A1 - Wright, Matthew C. A1 - Zeilinger, Katrin T1 - Dexamethasone induced hepatic differentiation of rat pancreatic progenitor cells (B-13) in a 3D multicompartment bioreactor system T2 - Journal of hepatology Y1 - 2013 SN - 0168-8278 VL - 58 IS - 1 SP - S416 EP - S416 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Fayyaz, Susann A1 - Hartmann, Bolette A1 - Hanack, Katja A1 - Michelchen, Sophia A1 - Kreiling, Reinhard T1 - Development of a hematopoietic stem cell (murine system) based system as an alternative for the in vivo T-cell-dependent antibody response (TDAR) assay within the EOGRTS: case-study with Parabens T2 - Toxicology letters Y1 - 2022 U6 - https://doi.org/10.1016/j.toxlet.2022.07.483 SN - 0378-4274 SN - 1879-3169 VL - 368 SP - S175 EP - S176 PB - Elsevier Science CY - Amsterdam [u.a.] ER - TY - CHAP A1 - Risius, Marten A1 - Baumann, Annika A1 - Krasnova, Hanna T1 - Developing a new paradigm BT - introducing the intention-behaviour gap to the privacy paradox phenomenon T2 - Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research Papers N2 - Internet users commonly agree that it is important for them to protect their personal data. However, the same users readily disclose their data when requested by an online service. The dichotomy between privacy attitude and actual behaviour is commonly referred to as the “privacy paradox”. Over twenty years of research were not able to provide one comprehensive explanation for the paradox and seems even further from providing actual means to overcome the paradox. We argue that the privacy paradox is not just an instantiation of the attitude-behaviour gap. Instead, we introduce a new paradigm explaining the paradox as the result of attitude-intention and intentionbehaviour gaps. Historically, motivational goal-setting psychologists addressed the issue of intentionbehaviour gaps in terms of the Rubicon Model of Action Phases and argued that commitment and volitional strength are an essential mechanism that fuel intentions and translate them into action. Thus, in this study we address the privacy paradox from a motivational psychological perspective by developing two interventions on Facebook and assess whether the 287 participants of our online experiment actually change their privacy behaviour. The results demonstrate the presence of an intentionbehaviour gap and the efficacy of our interventions in reducing the privacy paradox. KW - privacy paradox KW - intention-behaviour gap KW - attitude-behaviour gap KW - commitment KW - rubicon model KW - social media Y1 - 2020 UR - https://aisel.aisnet.org/ecis2020_rp/150 UR - https://www.researchgate.net/publication/341507497_Developing_a_New_Paradigm_Introducing_the_Intention-Behaviour_Gap_to_the_Privacy_Paradox_Phenomenon/link/5ec4a1c892851c11a8778d3f/download?_tp=eyJjb250ZXh0Ijp7InBhZ2UiOiJwdWJsaWNhdGlvbiIsInByZXZpb3VzUGFnZSI6bnVsbH19 PB - AIS Electronic Library (AISeL) CY - [Erscheinungsort nicht ermittelbar] ER - TY - CHAP A1 - Gronau, Norbert A1 - Grum, Marcus A1 - Bender, Benedict T1 - Determining the optimal level of autonomy in cyber-physical production systems T2 - IEEE 14th International Conference on Industrial Informatics (INDIN) N2 - Traditional production systems are enhanced by cyber-physical systems (CPS) and Internet of Things. A kind of next generation systems, those cyber-physical production systems (CPPS) are able to raise the level of autonomy of its production components. To find the optimal degree of autonomy in a given context, a research approach is formulated using a simulation concept. Based on requirements and assumptions, a cyber-physical market is modeled and qualitative hypotheses are formulated, which will be verified with the help of the CPPS of a hybrid simulation environment. KW - cyber-physical systems KW - hybrid simulation KW - Internet of Things KW - manufacturing systems KW - production engineering computing KW - cyber-physical production systems Y1 - 2017 U6 - https://doi.org/10.1109/INDIN.2016.7819367 SP - 1293 EP - 1299 PB - IEEE CY - New York ER -