TY - JOUR A1 - Rickert, D. A1 - Moses, M. A. A1 - Lendlein, Andreas A1 - Kelch, S. A1 - Franke, R. P. T1 - The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tissue Y1 - 2003 ER - TY - JOUR A1 - Rickert, D. A1 - Lendlein, Andreas A1 - Schmidt, A. M. A1 - Kelch, S. A1 - Roehlke, W. A1 - Fuhrmann, R. A1 - Franke, R. P. T1 - In vitro cytotoxicity testing of AB-polymer networks based on oligo(epsilon-caprolactone) segments after different sterilization techniques Y1 - 2003 ER - TY - JOUR A1 - Kelch, S. A1 - Lendlein, Andreas A1 - Müllen, A. A1 - Ridder, U. T1 - Textile Polymergerüste für das Tissue Engineering Y1 - 2003 ER - TY - JOUR A1 - Kelch, S. A1 - Lendlein, Andreas A1 - Müllen, A. A1 - Ridder, U. T1 - Textile Polymer Scaffolds for Tissue Engineering Y1 - 2003 ER - TY - JOUR A1 - Rickert, D. A1 - Lendlein, Andreas A1 - Kelch, S. A1 - Moses, M. A. A1 - Franke, R. P. T1 - Biokompatibilitätstestung von bioabbaubaren Shape Memory Polymeren in vivo Y1 - 2004 ER - TY - JOUR A1 - Groth, Thomas A1 - Lendlein, Andreas T1 - Layer-by-layer deposition of polyelectrolytes : a versatile tool for the in vivo repair of blood vessels and the preparation of biocompatible implant coatings Y1 - 2004 ER - TY - JOUR A1 - Santoso, F. A1 - Schroeter, M. A1 - Wagner, Albrecht A1 - Lendlein, Andreas A1 - Sckomaecker, R. T1 - Simultane Funktionalisierung und Porenöffnung von Polyetherimid-Membranen zur Entwicklung neuer Trägermaterialien für die Apharese Y1 - 2004 ER - TY - JOUR A1 - Binzen, Eva A1 - Lendlein, Andreas A1 - Kelch, S. A1 - Rickert, D. A1 - Franke, R. P. T1 - Biomaterial-microvasculature interaction on polymers after implantation in mice Y1 - 2004 ER - TY - JOUR A1 - Groth, Thomas A1 - Lendlein, Andreas T1 - In-vivo-Reparatur von Blutgefäßen durch alternierende Adsorption von Polyelektrolyten Y1 - 2004 UR - http://www3.interscience.wiley.com/cgi-bin/fulltext/107614315/PDFSTART ER - TY - JOUR A1 - Kelch, S. A1 - Lendlein, Andreas A1 - Schulte, J. T1 - Kunststoffe mit Formgedächtnis : die erstaunlichen Fähigkeiten intelligenter Materialien Y1 - 2004 SN - 0344-5690 ER - TY - JOUR A1 - Feng, Y. A1 - Kelch, S. A1 - Rickert, D. A1 - Fuhrmann, R. A1 - Franke, R. P. A1 - Lendlein, Andreas T1 - Biokompatible abbaubare Formgedächtnispolymersysteme als intelligente Implantatmaterialien Y1 - 2004 ER - TY - JOUR A1 - Lendlein, Andreas A1 - Kelch, S. A1 - Schulte, J. A1 - Kratz, K. T1 - Shape-memory polymers Y1 - 2004 ER - TY - JOUR A1 - Rickert, D A1 - Lendlein, Andreas A1 - Kelch, S A1 - Franke, R. P. A1 - Moses, M. A. T1 - Cell proliferation and cellular activity of primary cell cultures of the oral cavity after cell seeding on the surface of a degradable, thermoplastic block copolymer N2 - Using standard cell biological and biochemical methods we were able to test the ability of a degradable, thermoplastic block copolymer to support the adhesion, proliferation, and the cellular activity of primary cell cultures of the oral cavity in vitro. The delicate balance between a group of endogenous enzymes, Matrix Metalloproteinases (MMPs), and their inhibitors (Tissue Inhibitor of MMPs, TIMPs) have a decisive function in the remodeling of the extracellular matrix during processes like wound healing or the integration of biomaterials in surrounding tissues after implantation. Recently developed, biodegradable thermoplastic elastomers with shape-memory properties may be the key to develop new therapeutical options in head and neck surgery. Primary cell cultures of the oral cavity of Sprague-Dawley rats were seeded on the surface of a thermoplastic block copolymer and on a polystyrene surface as control. Conditioned media of the primary cells were analyzed for MMPs and TIMPs after different periods of cell growth. The MMP and TIMP expression was analysed by zymography and a radiometric enzyme assay. No statistically significant differences in the appearance and the kinetic of MMP-1, MMP-2, MMP-9 and TIMPs were detected between cells grown on the polymer surface compared to the control. An appropriate understanding of the molecular processes that regulate cellular growth and integration of a biomaterial in surrounding tissue is the requirement for an optimal adaptation of biodegradable, polymeric biomaterials to the physiological, anatomical, and surgical conditions in vivo to develop new therapeutic options in otolaryngology and head and neck surgery Y1 - 2005 ER - TY - JOUR A1 - Nöchel, Ulrich A1 - Reddy, Chaganti Srinivasa A1 - Wang, Ke A1 - Cui, Jing A1 - Zizak, Ivo A1 - Behl, Marc A1 - Kratz, Karl A1 - Lendlein, Andreas T1 - Nanostructural changes in crystallizable controlling units determine the temperature-memory of polymers JF - Journal of Materials Chemistry A, Materials for energy and sustainability N2 - Temperature-memory polymers remember the temperature, where they were deformed recently, enabled by broad thermal transitions. In this study, we explored a series of crosslinked poly[ethylene-co-(vinyl acetate)] networks (cPEVAs) comprising crystallizable polyethylene (PE) controlling units exhibiting a pronounced temperature-memory effect (TME) between 16 and 99 °C related to a broad melting transition (∼100 °C). The nanostructural changes in such cPEVAs during programming and activation of the TME were analyzed via in situ X-ray scattering and specific annealing experiments. Different contributions to the mechanism of memorizing high or low deformation temperatures (Tdeform) were observed in cPEVA, which can be associated to the average PE crystal sizes. At high deformation temperatures (>50 °C), newly formed PE crystals, which are established during cooling when fixing the temporary shape, dominated the TME mechanism. In contrast, at low Tdeform (<50 °C), corresponding to a cold drawing scenario, the deformation led preferably to a disruption of existing large crystals into smaller ones, which then fix the temporary shape upon cooling. The observed mechanism of memorizing a deformation temperature might enable the prediction of the TME behavior and the knowledge based design of other TMPs with crystallizable controlling units. Y1 - 2015 U6 - https://doi.org/10.1039/c4ta06586g SN - 2050-7488 SN - 2050-7496 VL - 16 IS - 3 SP - 8284 EP - 8293 PB - Royal Society of Chemistry CY - Cambridge ER -