TY - JOUR A1 - Sternagel, Jörg T1 - Momente des Ethischen. Neuere Literatur zu Maurice Merleau-Ponty JF - Philosophische Rundschau Y1 - 2016 U6 - https://doi.org/10.1628/003181516X14677259134141 SN - 0031-8159 SN - 1868-7261 VL - 63 SP - 143 EP - 159 PB - J. C. B. Mohr CY - Tübingen ER - TY - JOUR A1 - Reichetzeder, Christoph A1 - Putra, Sulistyo Emantoko Dwi A1 - Li, Jian A1 - Hocher, Berthold T1 - Developmental Origins of Disease - Crisis Precipitates Change JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology N2 - The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype. KW - Nutrition KW - Thrifty phenotype KW - Developmental programming KW - Paternal, maternal, sex differences KW - Epigenetics Y1 - 2016 U6 - https://doi.org/10.1159/000447801 SN - 1015-8987 SN - 1421-9778 VL - 39 SP - 919 EP - 938 PB - Karger CY - Basel ER - TY - JOUR A1 - Sperfeld, Erik A1 - Raubenheimer, David A1 - Wacker, Alexander T1 - Bridging factorial and gradient concepts of resource co-limitation: towards a general framework applied to consumers JF - Ecology letters N2 - Organism growth can be limited either by a single resource or by multiple resources simultaneously (co-limitation). Efforts to characterise co-limitation have generated two influential approaches. One approach uses limitation scenarios of factorial growth assays to distinguish specific types of co-limitation; the other uses growth responses spanned over a continuous, multi-dimensional resource space to characterise different types of response surfaces. Both approaches have been useful in investigating particular aspects of co-limitation, but a synthesis is needed to stimulate development of this recent research area. We address this gap by integrating the two approaches, thereby presenting a more general framework of co-limitation. We found that various factorial (co-)limitation scenarios can emerge in different response surface types based on continuous availabilities of essential or substitutable resources. We tested our conceptual co-limitation framework on data sets of published and unpublished studies examining the limitation of two herbivorous consumers in a two-dimensional resource space. The experimental data corroborate the predictions, suggesting a general applicability of our co-limitation framework to generalist consumers and potentially also to other organisms. The presented framework might give insight into mechanisms that underlie co-limitation responses and thus can be a seminal starting point for evaluating co-limitation patterns in experiments and nature. KW - Consumer KW - essential nutrient KW - factorial design KW - food quality KW - growth rate KW - multi-nutrient limitation KW - nutritional ecology KW - performance landscape KW - substitutable resource KW - synergistic effect Y1 - 2016 U6 - https://doi.org/10.1111/ele.12554 SN - 1461-023X SN - 1461-0248 VL - 19 SP - 201 EP - 215 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Haack, Timm A1 - Abdelilah-Seyfried, Salim T1 - The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis JF - Development : Company of Biologists N2 - Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes. KW - Endocardium KW - Cardiac development KW - Hemodynamics KW - Bmp KW - Kruppel-like factor 2 KW - Vegf KW - Mechanotransduction KW - Zebrafish KW - Mouse Y1 - 2016 U6 - https://doi.org/10.1242/dev.131425 SN - 0950-1991 SN - 1477-9129 VL - 143 SP - 373 EP - 386 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Omerbasic, Alina T1 - The Non-Identity Problem and the Ethics of Future People JF - Ethical theory and moral practice Y1 - 2016 U6 - https://doi.org/10.1007/s10677-015-9614-4 SN - 1386-2820 SN - 1572-8447 VL - 19 SP - 273 EP - 275 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Yan, Wenhao A1 - Chen, Dijun A1 - Kaufmann, Kerstin T1 - Molecular mechanisms of floral organ specification by MADS domain proteins JF - Current opinion in plant biology N2 - Flower development is a model system to understand organ specification in plants. The identities of different types of floral organs are specified by homeotic MADS transcription factors that interact in a combinatorial fashion. Systematic identification of DNA-binding sites and target genes of these key regulators show that they have shared and unique sets of target genes. DNA binding by MADS proteins is not based on ‘simple’ recognition of a specific DNA sequence, but depends on DNA structure and combinatorial interactions. Homeotic MADS proteins regulate gene expression via alternative mechanisms, one of which may be to modulate chromatin structure and accessibility in their target gene promoters. Y1 - 2016 U6 - https://doi.org/10.1016/j.pbi.2015.12.004 SN - 1369-5266 SN - 1879-0356 VL - 29 SP - 154 EP - 162 PB - Elsevier CY - London ER - TY - JOUR A1 - de Vinuesa, Amaya Garcia A1 - Abdelilah-Seyfried, Salim A1 - Knaus, Petra A1 - Zwijsen, An A1 - Bailly, Sabine T1 - BMP signaling in vascular biology and dysfunction JF - New journal of physics : the open-access journal for physics N2 - The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved. KW - Bone morphogenetic proteins (BMP) KW - Signaling KW - Vasculature KW - Development KW - Disease Y1 - 2016 U6 - https://doi.org/10.1016/j.cytogfr.2015.12.005 SN - 1359-6101 SN - 1879-0305 VL - 27 SP - 65 EP - 79 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Woodhouse, Jason Nicholas A1 - Makower, A. Katharina A1 - Yeung, Anna C. Y. A1 - Ongley, Sarah E. A1 - Micallef, Melinda L. A1 - Moffitt, Michelle C. A1 - Neilan, Brett A. T1 - Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria JF - Environmental microbiology reports N2 - A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of -omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin-producing and non-toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist. Y1 - 2016 U6 - https://doi.org/10.1111/1758-2229.12366 SN - 1758-2229 VL - 8 SP - 3 EP - 13 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Höne, Christin T1 - The Musical Novel: Imitation of Musical Structure, Performance and Reception in Contemporary Fiction JF - Geophysical research letters Y1 - 2016 U6 - https://doi.org/10.1093/ml/gcw001 SN - 0027-4224 SN - 1477-4631 VL - 97 SP - 190 EP - 191 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Gangloff, Niklas A1 - Ulbricht, Juliane A1 - Lorson, Thomas A1 - Schlaad, Helmut A1 - Luxenhofer, Robert T1 - Peptoids and Polypeptoids at the Frontier of Supra- and Macromolecular Engineering JF - Chemical reviews Y1 - 2016 U6 - https://doi.org/10.1021/acs.chemrev.5b00201 SN - 0009-2665 SN - 1520-6890 VL - 116 SP - 1753 EP - 1802 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Bacskai-Atkari, Julia T1 - Descriptive typology and linguistic theory: A study in the morphosyntax of relative clauses JF - Acta linguistica Hungarica : an international journal of linguistics Y1 - 2016 SN - 1216-8076 SN - 1588-2624 VL - 63 SP - 97 EP - 112 PB - Akadémiai Kiadó CY - Budapest ER - TY - JOUR A1 - D'Aprile, Iwan-Michelangelo T1 - Costuming Genders: Acting as an Invention of the Enlightenment JF - German history : the journal of the German History Societ Y1 - 2016 U6 - https://doi.org/10.1093/gerhis/ghv109 SN - 0266-3554 SN - 1477-089X VL - 34 SP - 138 EP - 139 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Haßler, Gerda T1 - French in the Baroque and Enlightenment. Studies on the Linguistic Thinking in Germany in the 17th and 18th Centuries JF - Zeitschrift für Romanische Philologie Y1 - 2016 U6 - https://doi.org/10.1515/zrp-2016-0014 SN - 0049-8661 SN - 1865-9063 VL - 132 SP - 279 EP - 286 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Doetterl, Sebastian A1 - Berhe, Asmeret Asefaw A1 - Nadeu, Elisabet A1 - Wang, Zhengang A1 - Sommer, Michael A1 - Fiener, Peter T1 - Erosion, deposition and soil carbon: A review of process-level controls, experimental tools and models to address C cycling in dynamic landscapes JF - Earth science reviews : the international geological journal bridging the gap between research articles and textbooks N2 - The role of soil erosion in terrestrial carbon (C) sequestration and release remains one of the most important uncertainties in our attempts to determine the potential of soils to mediate climate change. Despite its widely recognized importance for terrestrial C sequestration, to date, no Earth System Model (ESM) implements soil erosion effects on carbon cycling in sufficient detail. So far, available studies have mostly investigated the magnitude of erosional C transport and in-situ measurements of vertical C fluxes on the catchment or regional scale. Recognizing the need to adequately represent C erosion processes and controls in ESMs, we provide a comprehensive cross-disciplinary review on lateral C redistribution in the landscape and discuss the implications for bio-geochemical cycling of carbon. We present current knowledge on the role of erosional C distribution in controlling the stabilization and release of C in soils, taking into consideration the important geomorphic, ecological, hydrologic, pedologic and micro-climatic processes and controls that affect soil organic carbon (SOC) stock, fluxes, and persistence in dynamic landscapes. Further, we provide an overview on latest experimental and modelling approaches that are being used to investigate the role of erosion in the carbon cycle. Finally, to advance our understanding of the role of soil redistribution in biogeochemical cycles of essential elements, we discuss the most promising topics for future research in this field. (C) 2015 Elsevier B.V. All rights reserved. KW - Soil erosion KW - Soil deposition KW - Carbon redistribution KW - Terrestrial C sink Y1 - 2016 U6 - https://doi.org/10.1016/j.earscirev.2015.12.005 SN - 0012-8252 SN - 1872-6828 VL - 154 SP - 102 EP - 122 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Prieske, Olaf A1 - Mühlbauer, Thomas A1 - Granacher, Urs T1 - The Role of Trunk Muscle Strength for Physical Fitness and Athletic Performance in Trained Individuals: A Systematic Review and Meta-Analysis JF - Sports medicine N2 - Background The importance of trunk muscle strength (TMS) for physical fitness and athletic performance has been demonstrated by studies reporting significant correlations between those capacities. However, evidence-based knowledge regarding the magnitude of correlations between TMS and proxies of physical fitness and athletic performance as well as potential effects of core strength training (CST) on TMS, physical fitness and athletic performance variables is currently lacking for trained individuals. Objective The aims of this systematic review and meta-analysis were to quantify associations between variables of TMS, physical fitness and athletic performance and effects of CST on these measures in healthy trained individuals. Data Sources PubMed, Web of Science, and SPORTDiscus were systematically screened from January 1984 to March 2015. Study Eligibility Criteria Studies were included that investigated healthy trained individuals aged 16-44 years and tested at least one measure of TMS, muscle strength, muscle power, balance, and/or athletic performance. Results Small-sized relationships of TMS with physical performance measures (-0.05 <= r <= 0.18) were found in 15 correlation studies. Sixteen intervention studies revealed large effects of CST on measures of TMS (SMD = 1.07) but small-to-medium-sized effects on proxies of physical performance (0 <= SMD <= 0.71) compared with no training or regular training only. The methodological quality of CST studies was low (median PEDro score = 4). Conclusions Our findings indicate that TMS plays only a minor role for physical fitness and athletic performance in trained individuals. In fact, CST appears to be an effective means to increase TMS and was associated with only limited gains in physical fitness and athletic performance measures when compared with no or only regular training. Y1 - 2016 U6 - https://doi.org/10.1007/s40279-015-0426-4 SN - 0112-1642 SN - 1179-2035 VL - 46 SP - 401 EP - 419 PB - Springer CY - Northcote ER - TY - JOUR A1 - Reimer, Anna Maria T1 - Identitas Oriens: Discursive Constructions of Identity and Alterity in British Orient Travelogues JF - Zeitschrift für Anglistik und Amerikanistik : a quarterly of language, literature and cultur Y1 - 2016 U6 - https://doi.org/10.1515/zaa-2016-0010 SN - 0044-2305 SN - 2196-4726 VL - 64 SP - 112 EP - 114 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Goychuk, Igor T1 - Molecular machines operating on the nanoscale: from classical to quantum JF - Beilstein journal of nanotechnology N2 - The main physical features and operating principles of isothermal nanomachines in the microworld, common to both classical and quantum machines, are reviewed. Special attention is paid to the dual, constructive role of dissipation and thermal fluctuations, the fluctuation-dissipation theorem, heat losses and free energy transduction, thermodynamic efficiency, and thermodynamic efficiency at maximum power. Several basic models are considered and discussed to highlight generic physical features. This work examines some common fallacies that continue to plague the literature. In particular, the erroneous beliefs that one should minimize friction and lower the temperature for high performance of Brownian machines, and that the thermodynamic efficiency at maximum power cannot exceed one-half are discussed. The emerging topic of anomalous molecular motors operating subdiffusively but very efficiently in the viscoelastic environment of living cells is also discussed. KW - anomalous dynamics with memory KW - Brownian nanomachines KW - nanoscale friction and thermal noise KW - quantum effects KW - thermodynamic efficiency Y1 - 2016 U6 - https://doi.org/10.3762/bjnano.7.31 SN - 2190-4286 VL - 7 SP - 328 EP - 350 PB - Beilstein-Institut zur Förderung der Chemischen Wissenschaften CY - Frankfurt, Main ER - TY - JOUR A1 - Terao, Mineko A1 - Romao, Maria Joao A1 - Leimkühler, Silke A1 - Bolis, Marco A1 - Fratelli, Maddalena A1 - Coelho, Catarina A1 - Santos-Silva, Teresa A1 - Garattini, Enrico T1 - Structure and function of mammalian aldehyde oxidases JF - Archives of toxicology : official journal of EUROTOX N2 - Mammalian aldehyde oxidases (AOXs; EC1.2.3.1) are a group of conserved proteins belonging to the family of molybdo-flavoenzymes along with the structurally related xanthine dehydrogenase enzyme. AOXs are characterized by broad substrate specificity, oxidizing not only aromatic and aliphatic aldehydes into the corresponding carboxylic acids, but also hydroxylating a series of heteroaromatic rings. The number of AOX isoenzymes expressed in different vertebrate species is variable. The two extremes are represented by humans, which express a single enzyme (AOX1) in many organs and mice or rats which are characterized by tissue-specific expression of four isoforms (AOX1, AOX2, AOX3, and AOX4). In vertebrates each AOX isoenzyme is the product of a distinct gene consisting of 35 highly conserved exons. The extant species-specific complement of AOX isoenzymes is the result of a complex evolutionary process consisting of a first phase characterized by a series of asynchronous gene duplications and a second phase where the pseudogenization and gene deletion events prevail. In the last few years remarkable advances in the elucidation of the structural characteristics and the catalytic mechanisms of mammalian AOXs have been made thanks to the successful crystallization of human AOX1 and mouse AOX3. Much less is known about the physiological function and physiological substrates of human AOX1 and other mammalian AOX isoenzymes, although the importance of these proteins in xenobiotic metabolism is fairly well established and their relevance in drug development is increasing. This review article provides an overview and a discussion of the current knowledge on mammalian AOX. KW - Aldehyde oxidase KW - Molybdo-flavoenzymes KW - Xanthine oxidoreductase KW - Drug metabolism Y1 - 2016 U6 - https://doi.org/10.1007/s00204-016-1683-1 SN - 0340-5761 SN - 1432-0738 VL - 90 SP - 753 EP - 780 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Nickerson, David A1 - Atalag, Koray A1 - de Bono, Bernard A1 - Geiger, Joerg A1 - Goble, Carole A1 - Hollmann, Susanne A1 - Lonien, Joachim A1 - Mueller, Wolfgang A1 - Regierer, Babette A1 - Stanford, Natalie J. A1 - Golebiewski, Martin A1 - Hunter, Peter T1 - The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable JF - Interface focus N2 - Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome. KW - Human Physiome KW - standards KW - repositories KW - service infrastructure KW - reproducible science KW - managing big data Y1 - 2016 U6 - https://doi.org/10.1098/rsfs.2015.0103 SN - 2042-8898 SN - 2042-8901 VL - 6 SP - 57 EP - 61 PB - Royal Society CY - London ER - TY - JOUR A1 - Rajasundaram, Dhivyaa A1 - Selbig, Joachim T1 - analysis JF - Current opinion in plant biology N2 - The development of ‘omics’ technologies has progressed to address complex biological questions that underlie various plant functions thereby producing copious amounts of data. The need to assimilate large amounts of data into biologically meaningful interpretations has necessitated the development of statistical methods to integrate multidimensional information. Throughout this review, we provide examples of recent outcomes of ‘omics’ data integration together with an overview of available statistical methods and tools. Y1 - 2016 U6 - https://doi.org/10.1016/j.pbi.2015.12.010 SN - 1369-5266 SN - 1879-0356 VL - 30 SP - 57 EP - 61 PB - Elsevier CY - London ER -