TY  - JOUR
A1  - Leonhardt, Helmar
A1  - Gerhardt, Matthias
A1  - Hoeppner, Nadine
A1  - Krüger, Kirsten
A1  - Tarantola, Marco
A1  - Beta, Carsten
T1  - Cell-substrate impedance fluctuations of single amoeboid cells encode cell-shape and adhesion dynamics
JF  - Physical review : E, Statistical, nonlinear and soft matter physics
N2  - We show systematic electrical impedance measurements of single motile cells on microelectrodes. Wild-type cells and mutant strains were studied that differ in their cell-substrate adhesion strength. We recorded the projected cell area by time-lapse microscopy and observed irregular oscillations of the cell shape. These oscillations were correlated with long-term variations in the impedance signal. Superposed to these long-term trends, we observed fluctuations in the impedance signal. Their magnitude clearly correlated with the adhesion strength, suggesting that strongly adherent cells display more dynamic cell-substrate interactions.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevE.93.012414
SN  - 2470-0045
SN  - 2470-0053
VL  - 93
PB  - American Physical Society
CY  - College Park
ER  -