TY  - JOUR
A1  - Fasciotti, Maira
A1  - Sanvido, Gustavo B.
A1  - Santos, Vanessa G.
A1  - Lalli, Priscila M.
A1  - McCullagh, Michael
A1  - de Sa, Gilberto F.
A1  - Daroda, Romeu J.
A1  - Peter, Martin G.
A1  - Eberlin, Marcos N.
T1  - Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas
JF  - Journal of mass spectrometr
N2  - The use of CO2 as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (Rp-p), as compared with N2, for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline Rp-p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (Rp-p?=?0.76), maltose and sucrose (Rp-p?=?1.04), and maltose and lactose (Rp-p?=?0.74). Ion mobility mass spectrometry using CO2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.
KW  - isomer resolution
KW  - oligosaccharides
KW  - traveling wave ion mobility mass spectrometry
KW  - polarizable drift gases
Y1  - 2012
U6  - https://doi.org/10.1002/jms.3089
SN  - 1076-5174
VL  - 47
IS  - 12
SP  - 1643
EP  - 1647
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Paz, Cristian
A1  - Peter, Martin G.
A1  - Schmidt, Bernd
A1  - Becerra, Jose
A1  - Gutierrez, Margarita
A1  - Astudillo, Luis
A1  - Silva, Mario
T1  - Synthesis and AChE inhibiting activity of 2, 4 substituted 6-Phenyl Pyrimidines
JF  - Journal of the Chilean Chemical Society
N2  - Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50=90 mu M, with no inhibition of BuChE.
KW  - Pyrimidines
KW  - inhibition AChE
KW  - mitsunobu
KW  - TBTU
Y1  - 2012
SN  - 0717-9324
VL  - 57
IS  - 3
SP  - 1292
EP  - 1294
PB  - Sociedad Chilena De Quimica
CY  - Concepcion
ER  -