TY  - JOUR
A1  - Wischerhoff, Erik
A1  - Badi, Nezha
A1  - Laschewsky, André
A1  - Lutz, Jean-Francois
ED  - Börner, Hans Gerhard
ED  - Lutz, JF
T1  - Smart polymer surfaces concepts and applications in biosciences
JF  - Advances in polymer science = Fortschritte der Hochpolymeren-Forschung
JF  - Advances in Polymer Science
N2  - Stimuli-responsive macromolecules (i.e., pH-, thermo-, photo-, chemo-, and bioresponsive polymers) have gained exponential importance in materials science, nanotechnology, and biotechnology during the last two decades. This chapter describes the usefulness of this class of polymer for preparing smart surfaces (e.g., modified planar surfaces, particles surfaces, and surfaces of three-dimensional scaffolds). Some efficient pathways for connecting these macromolecules to inorganic, polymer, or biological substrates are described. In addition, some emerging bioapplications of smart polymer surfaces (e.g., antifouling surfaces, cell engineering, protein chromatography, tissue engineering, biochips, and bioassays) are critically discussed.
KW  - Antifouling surfaces
KW  - Bioactive surfaces
KW  - Biocompatible polymers
KW  - Bioseparation
KW  - Cell engineering
KW  - Polymer-modified surfaces
KW  - Stimuli-responsive polymers
Y1  - 2011
SN  - 978-3-642-20154-7
U6  - https://doi.org/10.1007/12_2010_88
SN  - 0065-3195
VL  - 240
IS  - 1
SP  - 1
EP  - 33
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Melchert, Christian
A1  - Yongvongsoontorn, Nunnarpas
A1  - Behl, Marc
A1  - Lendlein, Andreas
T1  - Synthesis and characterization of telechelic oligoethers with terminal cinnamylidene acetic acid moieties
JF  - Journal of applied biomaterials & functional materials
N2  - Purpose: The formation of photoresponsive hydrogels were reported by irradiation of star-shaped poly(ethylene glycol)s with terminal cinnamylidene acetic acid (CAA) groups, which are capable of a photoinduced [2+2] cycloaddition. In this study we explored whether oligo(ethylene glycol) s and oligo(propylene glycol)s of varying molecular architecture (linear or star-shaped) or molecular weights could be functionalized with CAA as terminal groups by esterification or by amide formation.
 Methods: Oligo(ethylene glycol) (OEG) and oligo(propylene glycol) (OPG) with varying molecular architecture (linear, star-shaped) and weight average molecular weights between 1000 and 5000 g.mol(-1) were functionalized by means of esterification of hydroxyl or amine endgroups with cinnamylidene acetic acid (CAA) or cinnamylidene acetyl chloride (CAC) as telechelic endgroups. The chemical structure, thermal properties, and molecular weights of the oligoethers obtained were determined by NMR spectroscopy, UV spectroscopy, DSC, and MALDI-TOF.
 Results: CAA-functionalized linear and star-shaped OEGs or OPGs could be obtained with a degree of functionalization higher than 90%. In MALDI-TOF measurements an increase in Mw of about 150 g.mol(-1) (for each terminal end) after the functionalization reaction was observed. OEGCAA and OPGCAA showed an increase in glass transition temperature (T-g) from about -70 degrees C to -50 degrees C, compared to the unfunctionalized oligoethers. In addition, the melting temperature (T-m) of OEGCAA decreased from about 55 C to 30 degrees C, which can be accounted for by the hampered crystallization of the precursors because of the bulky CAA end groups as well as by the loss of the hydroxyl telechelic end groups.
 Conclusion: The synthesis of photoresponsive oligoethers containing cinnamylidene acetic acid as telechelic endgroup was reported and high degrees of functionalization could be achieved. Such photosensitive oligomers are promising candidates as reactive precursors, for the preparation of biocompatible high molecular weight polymers and polymer networks.
KW  - Biocompatible polymers
KW  - Cinnamylidene acetic acid
KW  - Photoresponsive polymers
Y1  - 2012
U6  - https://doi.org/10.5301/JABFM.2012.10364
SN  - 2280-8000
VL  - 10
IS  - 3
SP  - 185
EP  - 190
PB  - Wichtig
CY  - Milano
ER  -