TY  - JOUR
A1  - Bapolisi, Alain Murhimalika
A1  - Kielb, Patrycja
A1  - Bekir, Marek
A1  - Lehnen, Anne-Catherine
A1  - Radon, Christin
A1  - Laroque, Sophie
A1  - Wendler, Petra
A1  - Müller-Werkmeister, Henrike
A1  - Hartlieb, Matthias
T1  - Antimicrobial polymers of linear and bottlebrush architecture
BT  - Probing the membrane interaction and physicochemical properties
JF  - Macromolecular rapid communications : publishing the newsletters of the European Polymer Federation
N2  - Polymeric antimicrobial peptide mimics are a promising alternative for the future management of the daunting problems associated with antimicrobial resistance. However, the development of successful antimicrobial polymers (APs) requires careful control of factors such as amphiphilic balance, molecular weight, dispersity, sequence, and architecture. While most of the earlier developed APs focus on random linear copolymers, the development of APs with advanced architectures proves to be more potent. It is recently developed multivalent bottlebrush APs with improved antibacterial and hemocompatibility profiles, outperforming their linear counterparts. Understanding the rationale behind the outstanding biological activity of these newly developed antimicrobials is vital to further improving their performance. This work investigates the physicochemical properties governing the differences in activity between linear and bottlebrush architectures using various spectroscopic and microscopic techniques. Linear copolymers are more solvated, thermo-responsive, and possess facial amphiphilicity resulting in random aggregations when interacting with liposomes mimicking Escheria coli membranes. The bottlebrush copolymers adopt a more stable secondary conformation in aqueous solution in comparison to linear copolymers, conferring rapid and more specific binding mechanism to membranes. The advantageous physicochemical properties of the bottlebrush topology seem to be a determinant factor in the activity of these promising APs.
KW  - antimicrobial polymers
KW  - bottlebrush copolymers
KW  - liposomes
KW  - membrane
KW  - interactions
KW  - quartz crystal microbalance
Y1  - 2022
U6  - https://doi.org/10.1002/marc.202200288
SN  - 1521-3927
SN  - 1022-1336
VL  - 43
IS  - 19
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dani, Alessandro
A1  - Tauber, Karoline
A1  - Zhang, Weiyi
A1  - Schlaad, Helmut
A1  - Yuan, Jiayin
T1  - Stable Covalently Photo-Crosslinked Poly(Ionic Liquid) Membrane with Gradient Pore Size
JF  - Macromolecular rapid communications
N2  - Porous polyelectrolyte membranes stable in a highly ionic environment are obtained by covalent crosslinking of an imidazolium-based poly(ionic liquid). The crosslinking reaction involves the UV light-induced thiol-ene (click) chemistry, and the phase separation, occurring during the crosslinking step, generates a fully interconnected porous structure in the membrane. The porosity is on the order of the micrometer scale and the membrane shows a gradient of pore size across the membrane cross-section. The membrane can separate polystyrene latex particles of different size and undergoes actuation in contact with acetone due to the asymmetric porous structure.
KW  - membrane
KW  - photo-crosslinked
KW  - poly(ionic liquid)
KW  - porous structure
Y1  - 2017
U6  - https://doi.org/10.1002/marc.201700167
SN  - 1022-1336
SN  - 1521-3927
VL  - 38
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schwarze, Thomas
A1  - Müller, Holger
A1  - Ast, Sandra
A1  - Steinbrück, Dörte
A1  - Eidner, Sascha
A1  - Geißler, Felix
A1  - Kumke, Michael Uwe
A1  - Holdt, Hans-Jürgen
ED  - Kumke, Michael Uwe
T1  - Fluorescence lifetime-based sensing of sodium by an optode
JF  - Chemical Communications
N2  - We report a 1,2,3-triazol fluoroionophore for detecting Na+ that shows in vitro enhancement in the Na+-induced fluorescence intensity and decay time. The Na+-selective molecule 1 was incorporated into a hydrogel as a part of a fiber optical sensor. This sensor allows the direct determination of Na+ in the range of 1–10 mM by measuring reversible fluorescence decay time changes.
KW  - ion optodes
KW  - sensors
KW  - indicators
KW  - chromoionophore
KW  - ionophore
KW  - membrane
KW  - switches
KW  - systems
KW  - samples
KW  - green
Y1  - 2014
SN  - 0022-4936
SN  - 0009-241X
SP  - 14167
EP  - 14170
PB  - The Royal Society Chemistry
CY  - Cambridge
ER  -