TY  - JOUR
A1  - Bapolisi, Alain Murhimalika
A1  - Kielb, Patrycja
A1  - Bekir, Marek
A1  - Lehnen, Anne-Catherine
A1  - Radon, Christin
A1  - Laroque, Sophie
A1  - Wendler, Petra
A1  - Müller-Werkmeister, Henrike
A1  - Hartlieb, Matthias
T1  - Antimicrobial polymers of linear and bottlebrush architecture
BT  - Probing the membrane interaction and physicochemical properties
JF  - Macromolecular rapid communications : publishing the newsletters of the European Polymer Federation
N2  - Polymeric antimicrobial peptide mimics are a promising alternative for the future management of the daunting problems associated with antimicrobial resistance. However, the development of successful antimicrobial polymers (APs) requires careful control of factors such as amphiphilic balance, molecular weight, dispersity, sequence, and architecture. While most of the earlier developed APs focus on random linear copolymers, the development of APs with advanced architectures proves to be more potent. It is recently developed multivalent bottlebrush APs with improved antibacterial and hemocompatibility profiles, outperforming their linear counterparts. Understanding the rationale behind the outstanding biological activity of these newly developed antimicrobials is vital to further improving their performance. This work investigates the physicochemical properties governing the differences in activity between linear and bottlebrush architectures using various spectroscopic and microscopic techniques. Linear copolymers are more solvated, thermo-responsive, and possess facial amphiphilicity resulting in random aggregations when interacting with liposomes mimicking Escheria coli membranes. The bottlebrush copolymers adopt a more stable secondary conformation in aqueous solution in comparison to linear copolymers, conferring rapid and more specific binding mechanism to membranes. The advantageous physicochemical properties of the bottlebrush topology seem to be a determinant factor in the activity of these promising APs.
KW  - antimicrobial polymers
KW  - bottlebrush copolymers
KW  - liposomes
KW  - membrane
KW  - interactions
KW  - quartz crystal microbalance
Y1  - 2022
U6  - https://doi.org/10.1002/marc.202200288
SN  - 1521-3927
SN  - 1022-1336
VL  - 43
IS  - 19
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Klaper, Matthias
A1  - Linker, Torsten
T1  - Evidence for an oxygen anthracene sandwich complex
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
KW  - arenes
KW  - peroxides
KW  - sandwich complexes
KW  - singlet oxygen
KW  - interactions
Y1  - 2013
U6  - https://doi.org/10.1002/anie.201304768
SN  - 1433-7851
SN  - 1521-3773
VL  - 52
IS  - 45
SP  - 11896
EP  - 11899
PB  - Wiley-VCH
CY  - Weinheim
ER  -