TY - JOUR A1 - Induli, Martha A1 - Cheloti, Michael A1 - Wasuna, Antonina A1 - Wekesa, Ingrid A1 - Wanjohi, John M. A1 - Byamukama, Robert A1 - Heydenrich, Matthias A1 - Makayoto, Moses A1 - Yenesew, Abiy T1 - Naphthoquinones from the roots of Aloe secundiflora JF - Phytochemistry letters N2 - Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21-23 mu g/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mu g/mL). KW - Aloe secundiflora KW - Asphodelaceae KW - Roots KW - Naphthoquinone KW - 5-Hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione 5,8-Dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione KW - Anthraquinone KW - Aloesaponarin I KW - Mycobacterium tuberculosis Y1 - 2012 U6 - https://doi.org/10.1016/j.phytol.2012.04.014 SN - 1874-3900 VL - 5 IS - 3 SP - 506 EP - 509 PB - Elsevier CY - Amsterdam ER -