TY  - JOUR
A1  - Marsat, Jean-Noel
A1  - Stahlhut, Frank
A1  - Laschewsky, André
A1  - von Berlepsch, Hans
A1  - Böttcher, Christoph
T1  - Multicompartment micelles from silicone-based triphilic block copolymers
JF  - Colloid and polymer science : official journal of the Kolloid-Gesellschaft
N2  - An amphiphilic linear ternary block copolymer was synthesised in three consecutive steps via reversible addition-fragmentation chain transfer polymerisation. Oligo(ethylene glycol) monomethyl ether acrylate was engaged as a hydrophilic building block, while benzyl acrylate and 3-tris(trimethylsiloxy)silyl propyl acrylate served as hydrophobic building blocks. The resulting "triphilic" copolymer consists thus of a hydrophilic (A) and two mutually incompatible "soft" hydrophobic blocks, namely, a lipophilic (B) and a silicone-based (C) block, with all blocks having glass transition temperatures well below 0 A degrees C. The triphilic copolymer self-assembles into spherical multicompartment micellar aggregates in aqueous solution, where the two hydrophobic blocks undergo local phase separation into various ultrastructures as evidenced by cryogenic transmission electron microscopy. Thus, a silicone-based polymer block can replace the hitherto typically employed fluorocarbon-based hydrophobic blocks in triphilic block copolymers for inducing multicompartmentalisation.
KW  - Amphiphiles
KW  - Triphilic block copolymers
KW  - Core-shell-corona micelles
KW  - RAFT
KW  - Cryo-TEM
KW  - Multicompartment micelles
Y1  - 2013
U6  - https://doi.org/10.1007/s00396-013-3001-2
SN  - 0303-402X
SN  - 1435-1536
VL  - 291
IS  - 11
SP  - 2561
EP  - 2567
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Rosencrantz, Sophia
A1  - Tang, Jo Sing Julia
A1  - Schulte-Osseili, Christine
A1  - Böker, Alexander
A1  - Rosencrantz, Ruben R.
T1  - Glycopolymers by RAFT Polymerization as Functional Surfaces for Galectin-3
JF  - Macromolecular chemistry and physics
N2  - Glycan-protein interactions are essential biological processes with many disease-related modulations and variations. One of the key proteins involved in tumor progression and metastasis is galectin-3 (Gal-3). A lot of effort is put into the development of Gal-3 inhibitors as new therapeutic agents. The avidity of glycan-protein interactions is strongly enhanced by multivalent ligand presentation. Multivalent presentation of glycans can be accomplished by utilizing glycopolymers, which are polymers with pendent glycan groups. For the production of glycopolymers, glycomonomers are synthesized by a regioselective, microwave-assisted approach starting from lactose. The resulting methacrylamide derivatives are polymerized by RAFT and immobilized on gold surfaces using the trithiocarbonate group of the chain transfer agent. Surface plasmon resonance spectroscopy enables the label free kinetic characterization of Gal-3 binding to these multivalent glycopolymers. The measurements indicate oligomerization of Gal-3 upon exposure to multivalent environments and reveal strong specific interaction with the immobilized polymers.
KW  - galectin-3
KW  - glycopolymers
KW  - multivalency
KW  - RAFT
KW  - surface plasmon resonance
Y1  - 2019
U6  - https://doi.org/10.1002/macp.201900293
SN  - 1022-1352
SN  - 1521-3935
VL  - 220
IS  - 20
PB  - Wiley-VCH
CY  - Weinheim
ER  -