TY  - JOUR
A1  - Hardy, John G.
A1  - Bertin, Annabelle
A1  - Torres-Rendon, Jose Guillermo
A1  - Leal-Egana, Aldo
A1  - Humenik, Martin
A1  - Bauer, Felix
A1  - Walther, Andreas
A1  - Cölfen, Helmut
A1  - Schlaad, Helmut
A1  - Scheibel, Thomas R.
T1  - Facile photochemical modification of silk protein-based biomaterials
JF  - Macromolecular bioscience
N2  - Silk protein-based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein-based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk-based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer-modified silks are mineralized. The PAA- and PMAA-functionalized silks are mineralized with calcium carbonate, whereas the PAAm-functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.
KW  - biomaterials
KW  - chemical modification
KW  - photochemistry
KW  - silkworm silk
KW  - spider silk
Y1  - 2018
U6  - https://doi.org/10.1002/mabi.201800216
SN  - 1616-5187
SN  - 1616-5195
VL  - 18
IS  - 11
PB  - Wiley-VCH
CY  - Weinheim
ER  -