TY  - JOUR
A1  - Chepkirui, Carolyne
A1  - Ochieng, Purity J.
A1  - Sarkar, Biswajyoti
A1  - Hussain, Aabid
A1  - Pal, Chiranjib
A1  - Yang, Li Jun
A1  - Coghi, Paolo
A1  - Akala, Hoseah M.
A1  - Derese, Solomon
A1  - Ndakala, Albert
A1  - Heydenreich, Matthias
A1  - Wong, Vincent K. W.
A1  - Erdelyi, Mate
A1  - Yenesew, Abiy
T1  - Antiplasmodial and antileishmanial flavonoids from Mundulea sericea
JF  - Fitoterapia
N2  - Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 mu M against chloroquine-resistant W2, and 6.6 mu M against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 mu M, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 mu M) and HePG2 (IC50 10.8 mu M) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 mu M) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)
KW  - Mundulea sericea
KW  - leguminosae
KW  - flavanonol
KW  - flavonol
KW  - antiplasmodial
KW  - antileishmanial
KW  - cytotoxicity
Y1  - 2020
U6  - https://doi.org/10.1016/j.fitote.2020.104796
SN  - 0367-326X
SN  - 1873-6971
VL  - 149
PB  - Elsevier
CY  - Amsterdam
ER  -