TY  - JOUR
A1  - Baraza, Lilechi D.
A1  - Neser, Wekesa
A1  - Jackson, Korir Cheruiyot
A1  - Fredrick, Juma B.
A1  - Dennis, Ochieno
A1  - Wairimu, Kamau R.
A1  - Keya, Aggrey Osogo
A1  - Heydenreich, Matthias
T1  - Antimicrobial Coumarins from the Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), from Kenya
JF  - International journal of medicinal mushrooms
N2  - Pleurotus ostreatus has been widely used as food because of its nutritional and medicinal properties. These have been attributed to the presence of macronutrients, minerals, vitamins, and amino acids, among other secondary metabolites. There are, however, few reports on the antimicrobial activities of different classes of purified compounds from P. ostreatus. This led to the current study, the objective of which was to chemically characterize the antibiotic activities of P. ()streams against selected human pathogenic bacteria and endophytic fungi. Chemical structures were determined using spectroscopic methods and by comparison with values of related structures reported in the literature. Pure compounds from P. ostreatus were tested in vitro against pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and endophytic fungi (Pencillium digitatum and Fusarium prolferatum). A new compound, (E)-5,7-dimethoxy-6-(3-methylbuta-1,3-dienyl)-2H-chromen-2-one (5-methoxy-(E)-suberodiene) (compound 2), along with ergosterol (compound I.) and 5,7-dimethoxy-6-(3-methylbut-2-enyl)-2H-chromen-2-one (toddaculin; compound 3), were isolated from the fruiting bodies of P. ostreatus. The growth of S. aureus,E proliferatum, and P. digitatum colonies was inhibited in media containing compound 2, with minimum inhibitory concentrations closely comparable to those of conventional antibiotics.
KW  - Escherichia coli
KW  - Fusarium proliferatum
KW  - medicinal mushrooms
KW  - Penicillium digitatum
KW  - Pleurotus ostreatus
KW  - Staphylococcus aureus
Y1  - 2016
U6  - https://doi.org/10.1615/IntJMedMushrooms.v18.i10.60
SN  - 1521-9437
SN  - 1940-4344
VL  - 18
SP  - 905
EP  - 913
PB  - Begell House
CY  - Danbury
ER  -