TY  - JOUR
A1  - Bäckemo, Johan Dag Valentin
A1  - Liu, Yue
A1  - Lendlein, Andreas
T1  - Bio-inspired and computer-supported design of modulated shape changes in polymer materials
JF  - MRS communications / a publication of the Materials Research Society
N2  - The Venus flytrap is a fascinating plant with a finely tuned mechanical bi-stable system, which can switch between mono- and bi-stability. Here, we combine geometrical design of compliant mechanics and the function of shape-memory polymers to enable switching between bi- and mono-stable states. Digital design and modelling using the Chained Beam Constraint Model forecasted two geometries, which were experimentally realized as structured films of cross-linked poly[ethylene-co-(vinyl acetate)] supported by digital manufacturing. Mechanical evaluation confirmed our predicted features. We demonstrated that a shape-memory effect could switch between bi- and mono-stability for the same construct, effectively imitating the Venus flytrap.
KW  - Additive manufacturing
KW  - Biomimetic
KW  - Shape memory
KW  - Modelling
KW  - Polymer
Y1  - 2021
U6  - https://doi.org/10.1557/s43579-021-00056-6
SN  - 2159-6867
VL  - 11
IS  - 4
SP  - 462
EP  - 469
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Folikumah, Makafui Y.
A1  - Behl, Marc
A1  - Lendlein, Andreas
T1  - Reaction behaviour of peptide-based single thiol-thioesters exchange reaction substrate in the presence of externally added thiols
JF  - MRS communications / a publication of the Materials Research Society
N2  - Identification of patterns in chemical reaction pathways aids in the effective design of molecules for specific applications. Here, we report on model reactions with a water-soluble single thiol-thioester exchange (TTE) reaction substrate, which was designed taking in view biological and medical applications. This substrate consists of the thio-depsipeptide, Ac-Pro-Leu-Gly-SLeu-Leu-Gly-NEtSH (TDP) and does not yield foul-smelling thiol exchange products when compared with aromatic thiol containing single TTE substrates. TDP generates an alpha,omega-dithiol crosslinker in situ in a 'pseudo intramolecular' TTE. Competitive intermolecular TTE of TDP with externally added "basic" thiols increased the crosslinker concentration whilst "acidic" thiols decreased its concentration. TDP could potentially enable in situ bioconjugation and crosslinking applications.
KW  - Biomaterials
KW  - Biomimetic
KW  - Mass spectrometry
KW  - Nuclear magnetic resonance
KW  - (NMR)
Y1  - 2021
U6  - https://doi.org/10.1557/s43579-021-00041-z
SN  - 2159-6859
SN  - 2159-6867
VL  - 11
IS  - 4
SP  - 402
EP  - 410
PB  - Springer
CY  - Berlin
ER  -