TY  - GEN
A1  - Randall, Matthew J.
A1  - Jüngel, Astrid
A1  - Rimann, Markus
A1  - Wuertz-Kozak, Karin
T1  - Advances in the biofabrication of 3D skin in vitro
BT  - healthy and pathological models
T2  - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 680 
KW  - 3D tissue model
KW  - skin
KW  - in vitro
KW  - bioprinting
KW  - electrospinning
KW  - skin disease
KW  - biofabrication
KW  - preclinical testing
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-468844
SN  - 1866-8364
IS  - 680
ER  -