TY  - JOUR
A1  - Krumbholz, Julia
A1  - Ishida, Keishi
A1  - Baunach, Martin
A1  - Teikari, Jonna
A1  - Rose, Magdalena M.
A1  - Sasso, Severin
A1  - Hertweck, Christian
A1  - Dittmann, Elke
T1  - Deciphering chemical mediators regulating specialized metabolism in a symbiotic cyanobacterium
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker. International edition
N2  - Genomes of cyanobacteria feature a variety of cryptic biosynthetic pathways for complex natural products, but the peculiarities limiting the discovery and exploitation of the metabolic dark matter are not well understood. Here we describe the discovery of two cell density-dependent chemical mediators, nostoclide and nostovalerolactone, in the symbiotic model strain Nostoc punctiforme, and demonstrate their pronounced impact on the regulation of specialized metabolism. Through transcriptional, bioinformatic and labeling studies we assigned two adjacent biosynthetic gene clusters to the biosynthesis of the two polyketide mediators. Our findings provide insight into the orchestration of specialized metabolite production and give lessons for the genomic mining and high-titer production of cyanobacterial bioactive compounds.
KW  - Biosynthesis
KW  - Cyanobacteria
KW  - Genomic Mining
KW  - Quorum Sensing
KW  - Specialized
KW  - Metabolism
Y1  - 2022
U6  - https://doi.org/10.1002/anie.202204545
SN  - 1433-7851
SN  - 1521-3773
PB  - Wiley-VCH
CY  - Weinheim
ER  -