TY - JOUR A1 - Stiegler, Jonas A1 - Pahl, Janice A1 - Guillen, Rafael Arce A1 - Ullmann, Wiebke A1 - Blaum, Niels T1 - The heat is on BT - impacts of rising temperature on the activity of a common European mammal JF - Frontiers in Ecology and Evolution N2 - Climate conditions severely impact the activity and, consequently, the fitness of wildlife species across the globe. Wildlife can respond to new climatic conditions, but the pace of human-induced change limits opportunities for adaptation or migration. Thus, how these changes affect behavior, movement patterns, and activity levels remains unclear. In this study, we investigate how extreme weather conditions affect the activity of European hares (Lepus europaeus) during their peak reproduction period. When hares must additionally invest energy in mating, prevailing against competitors, or lactating, we investigated their sensitivities to rising temperatures, wind speed, and humidity. To quantify their activity, we used the overall dynamic body acceleration (ODBA) calculated from tri-axial acceleration measurements of 33 GPS-collared hares. Our analysis revealed that temperature, humidity, and wind speed are important in explaining changes in activity, with a strong response for high temperatures above 25 & DEG;C and the highest change in activity during temperature extremes of over 35 & DEG;C during their inactive period. Further, we found a non-linear relationship between temperature and activity and an interaction of activity changes between day and night. Activity increased at higher temperatures during the inactive period (day) and decreased during the active period (night). This decrease was strongest during hot tropical nights. At a stage of life when mammals such as hares must substantially invest in reproduction, the sensitivity of females to extreme temperatures was particularly pronounced. Similarly, both sexes increased their activity at high humidity levels during the day and low wind speeds, irrespective of the time of day, while the effect of humidity was stronger for males. Our findings highlight the importance of understanding the complex relationships between extreme weather conditions and mammal behavior, critical for conservation and management. With ongoing climate change, extreme weather events such as heat waves and heavy rainfall are predicted to occur more often and last longer. These events will directly impact the fitness of hares and other wildlife species and hence the population dynamics of already declining populations across Europe. KW - activity KW - ODBA KW - animal tracking KW - European hare KW - extreme weather events KW - climate change Y1 - 2023 U6 - https://doi.org/10.3389/fevo.2023.1193861 SN - 2296-701X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Dineva, Ekaterina Ivanova A1 - Pearson, Jeniveve A1 - Ilyin, Ilya A1 - Verma, Meetu A1 - Diercke, Andrea A1 - Strassmeier, Klaus A1 - Denker, Carsten T1 - Characterization of chromospheric activity based on Sun-as-a-star spectral and disk-resolved activity indices JF - Astronomische Nachrichten = Astronomical notes N2 - The strong chromospheric absorption lines Ca ii H & K are tightly connected to stellar surface magnetic fields. Only for the Sun, spectral activity indices can be related to evolving magnetic features on the solar disk. The Solar Disk-Integrated (SDI) telescope feeds the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) of the Large Binocular Telescope (LBT) at Mt. Graham International Observatory, Arizona, U.S.A. We present high-resolution, high-fidelity spectra that were recorded on 184 & 82 days in 2018 & 2019 and derive the Ca ii H & K emission ratio, that is, the S-index. In addition, we compile excess brightness and area indices based on full-disk Ca ii K-line-core filtergrams of the Chromospheric Telescope (ChroTel) at Observatorio del Teide, Tenerife, Spain and full-disk ultraviolet (UV) 1600 angstrom images of the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO). Thus, Sun-as-a-star spectral indices are related to their counterparts derived from resolved images of the solar chromosphere. All indices display signatures of rotational modulation, even during the very low magnetic activity in the minimum of Solar Cycle 24. Bringing together different types of activity indices has the potential to join disparate chromospheric datasets yielding a comprehensive description of chromospheric activity across many solar cycles. KW - astronomical databases KW - miscellaneous KW - methods KW - data analysis KW - activity KW - Sun KW - atmosphere KW - chromosphere KW - techniques KW - spectroscopic Y1 - 2022 U6 - https://doi.org/10.1002/asna.20223996 SN - 0004-6337 SN - 1521-3994 VL - 343 IS - 5 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Hawro, Tomasz A1 - Przybylowicz, Katarzyna A1 - Spindler, Max A1 - Hawro, Marlena A1 - Steć, Michał A1 - Altrichter, Sabine A1 - Weller, Karsten A1 - Magerl, Markus A1 - Reidel, Ulrich A1 - Alarbeed, Ezzat A1 - Alraboni, Ola A1 - Maurer, Marcus A1 - Metz, Martin T1 - The characteristics and impact of pruritus in adult dermatology patients BT - a prospective, cross-sectional study JF - Journal of the American Academy of Dermatology N2 - Background: Pruritus often accompanies chronic skin diseases, exerting considerable burden on many areas of patient functioning; this burden and the features of pruritus remain insufficiently characterized. Objective: To investigate characteristics, including localization patterns, and burden of pruritus in patients with chronic dermatoses. Methods: We recruited 800 patients with active chronic skin diseases. We assessed pruritus intensity, localization, and further characteristics. We used validated questionnaires to assess quality of life, work productivity and activity impairment, anxiety, depression, and sleep quality. Results: Nine out of every 10 patients had experienced pruritus throughout their disease and 73% in the last 7 days. Pruritus often affected the entire body and was not restricted to skin lesions. Patients with moderate to severe pruritus reported significantly more impairment to their sleep quality and work productivity, and they were more depressed and anxious than control individuals and patients with mild or no pruritus. Suicidal ideations were highly prevalent in patients with chronic pruritus (18.5%) and atopic dermatitis (11.8%). Conclusions: Pruritus prevalence and intensity are very high across all dermatoses studied; intensity is linked to impairment in many areas of daily functioning. Effective treatment strategies are urgently required to treat pruritus and the underlying skin disease. ( J Am Acad Dermatol 2021;84:691-700.) KW - activity KW - anxiety KW - depression KW - pruritus KW - quality of life KW - sleep quality KW - suicidal ideations KW - work productivity Y1 - 2021 U6 - https://doi.org/10.1016/J.JAAD.2020.08.035 SN - 0190-9622 SN - 1097-6787 VL - 84 IS - 3 SP - 691 EP - 700 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Gonzalez-Chavarria, Ivan A1 - Duprat, Felix A1 - Roa, Francisco J. A1 - Jara, Nery A1 - Toledo, Jorge R. A1 - Miranda, Felipe A1 - Becerra, Jose A1 - Inostroza, Alejandro A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Heydenreich, Matthias A1 - Paz, Cristian T1 - Maytenus disticha extract and an isolated β-Dihydroagarofuran induce mitochondrial depolarization and apoptosis in human cancer cells by increasing mitochondrial reactive oxygen species JF - Biomolecules N2 - Maytenus disticha (Hook F.), belonging to the Celastraceae family, is an evergreen shrub, native of the central southern mountains of Chile. Previous studies demonstrated that the total extract of M. disticha (MD) has an acetylcholinesterase inhibitory activity along with growth regulatory and insecticidal activities. beta-Dihydroagarofurans sesquiterpenes are the most active components in the plant. However, its activity in cancer has not been analyzed yet. Here, we demonstrate that MD has a cytotoxic activity on breast (MCF-7), lung (PC9), and prostate (C4-2B) human cancer cells with an IC50 (mu g/mL) of 40, 4.7, and 5 mu g/mL, respectively, an increasing Bax/Bcl2 ratio, and inducing a mitochondrial membrane depolarization. The beta-dihydroagarofuran-type sesquiterpene (MD-6), dihydromyricetin (MD-9), and dihydromyricetin-3-O-beta-glucoside (MD-10) were isolated as the major compounds from MD extracts. From these compounds, only MD-6 showed cytotoxic activity on MCF-7, PC9, and C4-2B with an IC50 of 31.02, 17.58, and 42.19 mu M, respectively. Furthermore, the MD-6 increases cell ROS generation, and MD and MD-6 induce a mitochondrial superoxide generation and apoptosis on MCF-7, PC9, and C4-2B, which suggests that the cytotoxic effect of MD is mediated in part by the beta-dihydroagarofuran-type that induces apoptosis by a mitochondrial dysfunction. KW - Maytenus disticha KW - beta-dihydroagarofuran-type sesquiterpene KW - dihydromyricetin KW - dihydromyricetin-3-O-beta-glucoside KW - cytotoxic KW - activity KW - Mitochondrial ROS Y1 - 2020 U6 - https://doi.org/10.3390/biom10030377 SN - 2218-273X VL - 10 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Foster, Grace A1 - Poppenhäger, Katja T1 - Identifying interesting planetary systems for future X-ray observations JF - Astronomische Nachrichten = Astronomical notes N2 - X-ray observations of star-planet systems are important to grow our understanding of exoplanets; these observations allow for studies of photoevaporation of the exoplanetary atmosphere, and in some cases even estimations of the size of the outer planetary atmosphere. The German-Russian eROSITA instrument onboard the SRG (Spectrum Roentgen Gamma) mission is performing the first all-sky X-ray survey since the 1990s, and provides X-ray fluxes and spectra of exoplanet host stars over a much larger volume than was accessible before. Using new eROSITA data as well as archival data from XMM-Newton, Chandra, and ROSAT, we estimate mass-loss rates of exoplanets under an energy-limited escape scenario and identify several exoplanets with strong X-ray irradiation and expected mass loss that are amenable to follow-up observations at other wavelengths. We model sample spectra using a toy model of an exoplanetary atmosphere to predict what exoplanet transit observations with future X-ray missions such as Athena will look like and estimate the observable X-ray transmission spectrum for a typical hot Jupiter-type exoplanet. KW - planets and satellites KW - general KW - stars KW - activity KW - coronae KW - planetary systems KW - X-rays Y1 - 2022 U6 - https://doi.org/10.1002/asna.20220007 SN - 1521-3994 VL - 343 IS - 4 PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Dammhahn, Melanie A1 - Lange, Pauline A1 - Eccard, Jana T1 - The landscape of fear has individual layers BT - an experimental test of among-individual differences in perceived predation risk during foraging JF - Oikos N2 - Perceived predation risk varies in space and time creating a landscape of fear. This key feature of an animal's environment is classically studied as a species-specific property. However, individuals differ in how they solve the tradeoff between safety and reward and may, hence, differ consistently and predictively in perceived predation risk across landscapes. To test this hypothesis, we quantified among-individual differences in boldness and activity and exposed behaviourally phenotyped male bank voles Myodes glareolus individually to two different experimental landscapes of risks in large outdoor enclosures and provided resources as discrete food patches. We manipulated perceived predation risk via vegetation height between 2 and > 30 cm and quantified patch use indirectly via RFID-logging and giving-up densities. We statistically disentangled among-individual differences in microhabitat use from spatially varying perceived risk, i.e. landscape of fear. We found that individuals varied in mean vegetation height of their foraging microhabitats and that this microhabitat selection matched the intrinsic individual differences in perceived risk. As predicted by the patch use model, all individual's perceived higher risks when foraging in lower vegetation. However, individuals differed in their reaction norm slopes of perceived risk to vegetation height, and these differences in slopes were consistent across two different landscapes of risks and resources. We interpret these results as evidence for individual landscapes of fear, which could be predicted by among-individual differences in activity and boldness. Since perceived predation risk affects when and where to forage, among-individual differences in fear responses could act as a mode of intraspecific niche complementarity (i.e. individual niche specialization), help explain behavioural type by environment correlations, and will likely have cascading indirect effects on lower trophic levels. KW - activity KW - behavioural reaction norm KW - giving-up density KW - patch use; KW - optimal foraging KW - personality KW - risk allocation KW - rodents Y1 - 2022 U6 - https://doi.org/10.1111/oik.09124 SN - 0030-1299 SN - 1600-0706 VL - 2022 IS - 6 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Verma, Meetu A1 - Kummerow, P. A1 - Denker, Carsten T1 - On the extent of the moat flow in axisymmetric sunspots JF - Astronomische Nachrichten = Astronomical notes N2 - Unipolar, axisymmetric sunspots are figuratively called “theoretician's sunspots” because their simplicity supposedly makes them more suitable for theoretical descriptions or numerical models. On November 18, 2013, a very large specimen (active region NOAA 11899) crossed the central meridian of the sun. The moat flow associated with this very large spot is quantitatively compared to that of a medium and a small sunspot to determine the extent of the moat flow in different environments. We employ continuum images and magnetograms of the Helioseismic and Magnetic Imager (HMI) as well as extreme ultraviolet (EUV) images at λ160 nm of the Atmospheric Imaging Assembly (AIA), both on board the Solar Dynamics Observatory (SDO), to measure horizontal proper motions with Local Correlation Tracking (LCT) and flux transport velocities with the Differential Affine Velocity Estimator (DAVE). We compute time-averaged flow maps (±6 hr around meridian passage) and radial averages of photometric, magnetic, and flow properties. Flow fields of a small- and a medium-sized axisymmetric sunspot provide the context for interpreting the results. All sunspots show outward moat flow and the advection of moving magnetic features (MMFs). However, the extent of the moat flow varies from spot to spot, and a correlation of flow properties with size is tenuous, if at all present. The moat flow is asymmetric and predominantly in the east–west direction, whereby deviations are related to the tilt angle of the sunspot group as well as to the topology and activity level of the trailing plage. KW - activity KW - data analysis KW - image processing KW - photosphere KW - sunspots Y1 - 2018 U6 - https://doi.org/10.1002/asna.201813482 SN - 0004-6337 SN - 1521-3994 VL - 339 IS - 4 SP - 268 EP - 276 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Poppenhäger, Katja T1 - How stars and planets interact BT - A look through the high-energy window JF - Astronomische Nachrichten = Astronomical notes N2 - The architecture of exoplanetary systems is often different from the solar system, with some exoplanets being in close orbits around their host stars and having orbital periods of only a few days. In analogy to interactions between stars in close binary systems, one may expect interactions between the star and the exoplanet as well. From theoretical considerations, effects on the host star through tidal and magnetic interaction with the exoplanet are possible; for the exoplanet, some interesting implications are the evaporation of the planetary atmosphere and potential effects on the planetary magnetism. In this review, several possible interaction pathways and their observational prospects and existing evidence are discussed. A particular emphasis is put on observational opportunities for these kinds of effects in the high-energy regime. KW - magnetic fields KW - planet-star interactions KW - stars KW - activity KW - X-rays Y1 - 2019 U6 - https://doi.org/10.1002/asna.201913619 SN - 0004-6337 SN - 1521-3994 VL - 340 IS - 4 SP - 329 EP - 333 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kowalski, Gabriele Joanna A1 - Grimm, Volker A1 - Herde, Antje A1 - Guenther, Anja A1 - Eccard, Jana T1 - Does Animal Personality Affect Movement in Habitat Corridors? BT - Experiments with Common Voles (Microtus arvalis) Using Different Corridor Widths JF - Animals N2 - Animal personality may affect an animal’s mobility in a given landscape, influencing its propensity to take risks in an unknown environment. We investigated the mobility of translocated common voles in two corridor systems 60 m in length and differing in width (1 m and 3 m). Voles were behaviorally phenotyped in repeated open field and barrier tests. Observed behavioral traits were highly repeatable and described by a continuous personality score. Subsequently, animals were tracked via an automated very high frequency (VHF) telemetry radio tracking system to monitor their movement patterns in the corridor system. Although personality did not explain movement patterns, corridor width determined the amount of time spent in the habitat corridor. Voles in the narrow corridor system entered the corridor faster and spent less time in the corridor than animals in the wide corridor. Thus, landscape features seem to affect movement patterns more strongly than personality. Meanwhile, site characteristics, such as corridor width, could prove to be highly important when designing corridors for conservation, with narrow corridors facilitating faster movement through landscapes than wider corridors. KW - activity KW - animal personality KW - wildlife corridors KW - habitat connectivity KW - individual differences KW - rodents Y1 - 2019 U6 - https://doi.org/10.3390/ani9060291 SN - 2076-2615 VL - 9 IS - 6 PB - MDPI CY - Basel ER -