TY  - JOUR
A1  - Muiva-Mutisya, Lois M.
A1  - Atilaw, Yoseph
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Akala, Hoseah M.
A1  - Cheruiyot, Agnes C.
A1  - Brown, Matthew L.
A1  - Irungu, Beatrice
A1  - Okalebo, Faith A.
A1  - Derese, Solomon
A1  - Mutai, Charles
A1  - Yenesew, Abiy
T1  - Antiplasmodial prenylated flavanonols from Tephrosia subtriflora
JF  - Natural Product Research
N2  - The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodiumfalciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4-4.6M without significant cytotoxicity against Vero and HEp2 cell lines (IC50>100M). The new compound (1) showed weak antiplasmodial activity, IC50 12.5-24.2M, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9M). [GRAPHICS] .
KW  - Tephrosia subtriflora
KW  - Leguminosae
KW  - prenylated flavanonol
KW  - subtriflavanonol
KW  - antiplasmodial
KW  - cytotoxicity
Y1  - 2018
U6  - https://doi.org/10.1080/14786419.2017.1353510
SN  - 1478-6419
SN  - 1478-6427
VL  - 32
IS  - 12
SP  - 1407
EP  - 1414
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  -