TY  - JOUR
A1  - Akampurira, Denis
A1  - Akala, Hoseah M.
A1  - Derese, Solomon
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
T1  - A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum
JF  - Natural product research
N2  - The CH2Cl2/MeOH (1:1) extract of Zanthoxylum holstzianum stem bark showed good antiplasmodial activity (IC50 2.5 +/- 0.3 and 2.6 +/- 0.3 mu g/mL against the W2 and D6 strains of Plasmodium falciparum, respectively). From the extract five benzophenanthridine alkaloids [8-acetonyldihydrochelerythrine (1), nitidine (2), dihydrochelerythine (3), norchelerythrine (5), arnottianamide (8)]; a 2-quinolone alkaloid [N-methylflindersine (4)]; a lignan [4,4 '-dihydroxy-3,3 '-dimethoxylignan-9,9 '-diyl diacetate (7)] and a dimer of a benzophenanthridine and 2-quinoline [holstzianoquinoline (6)] were isolated. The CH2Cl2/MeOH (1:1) extract of the root bark afforded 1, 3-6, 8, chelerythridimerine (9) and 9-demethyloxychelerythrine (10). Holstzianoquinoline (6) is new, and is the second dimer linked by a C-C bond of a benzophenanthridine and a 2-quinoline reported thus far. The compounds were identified based on spectroscopic evidence. Amongst five compounds (1-5) tested against two strains of P. falciparum, nitidine (IC50 0.11 +/- 0.01 mu g/mL against W2 and D6 strains) and norchelerythrine (IC50 value of 0.15 +/- 0.01 mu g/mL against D6 strain) were the most active.
KW  - Antiplasmodial
KW  - benzophenanthridine alkaloid
KW  - holstzianoquinoline;
KW  - rutaceae
KW  - Zanthoxylum holstzianum
Y1  - 2022
U6  - https://doi.org/10.1080/14786419.2022.2034810
SN  - 1478-6419
SN  - 1478-6427
VL  - 37
IS  - 13
SP  - 2161
EP  - 2171
PB  - Taylor & Francis
CY  - London [u.a.]
ER  -