TY  - JOUR
A1  - Singh, Jasbir
A1  - Dani, Harinder M.
A1  - Sharma, Reeta
A1  - Steinberg, Pablo
T1  - Inhibition of the biosynthesis of SRP polypeptides and secretory proteins by aflatoxin B-1 can disrupt protein targeting
JF  - Cell biochemistry and function
N2  - Cell culture and western blotting studies revealed that aflatoxin B-1 (AFB(1)) inhibits the biosynthesis of two of the constituent polypeptides of signal recognition particle (SRP) (SRP54 and 72). SRP escorts polyribosomes carrying signal peptides from free form in the cytosol to the bound form on endoplasmic reticulum (ER) membrane during protein targeting. These effects of AFB(1) on SRP biosynthesis may inhibit the formation of functional SRP Our experiments have further shown that AFB(1) also inhibits the biosynthesis/translocation of a secretory protein, preprolactin, which fails to appear in the lumen of ER consequent to the treatment with this hepatocarcinogen. The results of the experiments presented in this article therefore enable us to infer for the first time that aflatoxin B-1 may inhibit the functioning of SRP as an escort and deplete the ER of polyribosomes for secretory protein synthesis. As these secretory proteins are important components of the plasma membrane, gap junctions and intercellular matrix, their absence from these locations could disturb cell to cell communication leading to tumorigenesis.
KW  - aflatoxin B-1
KW  - SRP
KW  - protein targeting
KW  - protein translocation
KW  - western blotting
Y1  - 2005
U6  - https://doi.org/10.1027/cbf.1285
SN  - 0263-6484
VL  - 24
SP  - 507
EP  - 510
PB  - Wiley
CY  - Chichester
ER  - 
TY  - JOUR
A1  - Sharma, Reeta
A1  - Stuckas, Heiko
A1  - Bhaskar, Ranjana
A1  - Khan, Imran
A1  - Goyal, Surendra Prakash
A1  - Tiedemann, Ralph
T1  - Genetically distinct population of Bengal tiger (Panthera tigris tigris) in Terai Arc Landscape (TAL) of India
JF  - Mammalian biology = Zeitschrift für Säugetierkunde
N2  - We analyzed mtDNA polymorphisms (a total of 741 bp from a part of conserved control region, ND5, ND2, Cyt b and 12S) in 91 scats and 12 tissue samples of Bengal tiger (Panthera tigris tigris) populations across Terai Arc Landscape (TAL) located at the foothills of Himalayas in North Western India, Buxa Tiger Reserve (BTR), and North East India. In TAL and BTR, we found a specific haplotype at high frequency, which was absent elsewhere, indicating a genetically distinct population in these regions. Within the TAL region, there is some evidence for genetic isolation of the tiger populations west of river Ganges, i.e., in the western part of Rajaji National Park (RNP). Although the river itself might not constitute a significant barrier for tigers, recent human-induced changes in habitat and degradation of the Motichur-Chilla Corridor connecting the two sides of the tiger habitat of RNP might effectively prevent genetic exchange. A cohesive population is observed for the rest of the TAL. Even the more eastern BTR belongs genetically to this unit, despite the present lack of a migration corridor between BTR and TAL. In spite of a close geographic proximity, Chitwan (Nepal) constitutes a tiger population genetically different from TAL. Moreover, it is observed that the North East India tiger populations are genetically different from TAL and BTR, as well as from the other Bengal tiger populations in India.
KW  - Bengal tiger
KW  - Population genetics
KW  - mtDNA haplotype
KW  - Terai Arc
Y1  - 2011
U6  - https://doi.org/10.1016/j.mambio.2010.10.005
SN  - 1616-5047
VL  - 76
IS  - 4
SP  - 484
EP  - 490
PB  - Elsevier
CY  - Jena
ER  - 
TY  - GEN
A1  - Pokorny, Ina
A1  - Sharma, Reeta
A1  - Goyal, Surendra Prakash
A1  - Mishra, Sudanshu
A1  - Tiedemann, Ralph
T1  - MHC class I and MHC class II DRB gene variability in wild and captive Bengal tigers (Panthera tigris tigris) (vol 10, pg 667, 2010)
T2  - Immunogenetics
Y1  - 2011
U6  - https://doi.org/10.1007/s00251-010-0496-2
SN  - 0093-7711
VL  - 63
IS  - 2
SP  - 121
EP  - 121
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Sharma, Reeta
A1  - Stuckas, Heiko
A1  - Bhaskar, Ranjana
A1  - Rajput, Sandeep
A1  - Khan, Imran
A1  - Goyal, Surendra Prakash
A1  - Tiedemann, Ralph
T1  - mtDNA indicates profound population structure in Indian tiger (Panthera tigris tigris)
N2  - We analyzed mtDNA polymorphisms (parts of control region, ND5, ND2, Cytb, 12S, together 902 bp) in 59 scat and 18 tissue samples from 13 Indian populations of the critically endangered Indian tiger (Panthera tigris tigris), along with zoo animals as reference. Northern tiger populations exhibit two unique haplotypes suggesting genetic isolation. Western populations from Sariska (extinct in 2004) and Ranthambore are genetically similar, such that Ranthambore could serve as a source for reintroduction in Sariska. Zoo populations maintain mitochondrial lineages that are rare or absent in the wild.
Y1  - 2009
UR  - http://www.springerlink.com/content/105709
U6  - https://doi.org/10.1007/s10592-008-9568-3
SN  - 1566-0621
ER  - 
TY  - THES
A1  - Sharma, Reeta
T1  - Molecular genetic analysis of Bengal tiger (Panthera tigris tigres) population and its implication in conservation and wildlife forensics
Y1  - 2008
CY  - Potsdam
ER  -