TY  - JOUR
A1  - Walter, T.
A1  - Collenburg, Lena
A1  - Japtok, Lukasz
A1  - Kleuser, Burkhard
A1  - Schneider-Schaulies, Sibylle
A1  - Mueller, N.
A1  - Becam, Jerome
A1  - Schubert-Unkmeir, A.
A1  - Kong, J. N.
A1  - Bieberich, Erhard
A1  - Seibel, J.
T1  - Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells
JF  - Chemical communications
N2  - The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.
Y1  - 2016
U6  - https://doi.org/10.1039/c6cc02879a
SN  - 1359-7345
SN  - 1364-548X
VL  - 52
SP  - 8612
EP  - 8614
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Hollmann, C.
A1  - Reuter, D.
A1  - Werner, S.
A1  - Avota, Elita
A1  - Mueller, N.
A1  - Japtok, Lukasz
A1  - Kleuser, Burkhard
A1  - Becker, Katrin Anne
A1  - Gulbins, Erich
A1  - Schneider-Schaulies, Jürgen
A1  - Beyersdorf, Niklas
T1  - Pharmacological inhibition of acid sphingomyelinase or genetic ablation enhances CD4(+) Foxp3(+) regulatory T cell activity
T2  - European journal of immunology
Y1  - 2016
SN  - 0014-2980
SN  - 1521-4141
VL  - 46
SP  - 14
EP  - 14
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Aich, Valentin
A1  - Liersch, Stefan
A1  - Vetter, T.
A1  - Huang, S.
A1  - Tecklenburg, J.
A1  - Hoffmann, P.
A1  - Koch, H.
A1  - Fournet, S.
A1  - Krysanova, Valentina
A1  - Mueller, N.
A1  - Hattermann, Fred Fokko
T1  - Comparing impacts of climate change on streamflow in four large African river basins
JF  - Hydrology and earth system sciences : HESS
N2  - This study aims to compare impacts of climate change on streamflow in four large representative African river basins: the Niger, the Upper Blue Nile, the Oubangui and the Limpopo. We set up the eco-hydrological model SWIM (Soil and Water Integrated Model) for all four basins individually. The validation of the models for four basins shows results from adequate to very good, depending on the quality and availability of input and calibration data.
 For the climate impact assessment, we drive the model with outputs of five bias corrected Earth system models of Coupled Model Intercomparison Project Phase 5 (CMIP5) for the representative concentration pathways (RCPs) 2.6 and 8.5. This climate input is put into the context of climate trends of the whole African continent and compared to a CMIP5 ensemble of 19 models in order to test their representativeness. Subsequently, we compare the trends in mean discharges, seasonality and hydrological extremes in the 21st century. The uncertainty of results for all basins is high. Still, climate change impact is clearly visible for mean discharges but also for extremes in high and low flows. The uncertainty of the projections is the lowest in the Upper Blue Nile, where an increase in streamflow is most likely. In the Niger and the Limpopo basins, the magnitude of trends in both directions is high and has a wide range of uncertainty. In the Oubangui, impacts are the least significant. Our results confirm partly the findings of previous continental impact analyses for Africa. However, contradictory to these studies we find a tendency for increased streamflows in three of the four basins (not for the Oubangui). Guided by these results, we argue for attention to the possible risks of increasing high flows in the face of the dominant water scarcity in Africa. In conclusion, the study shows that impact intercomparisons have added value to the adaptation discussion and may be used for setting up adaptation plans in the context of a holistic approach.
Y1  - 2014
U6  - https://doi.org/10.5194/hess-18-1305-2014
SN  - 1027-5606
SN  - 1607-7938
VL  - 18
IS  - 4
SP  - 1305
EP  - 1321
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Gronau, Norbert
A1  - Wildemann, H.
A1  - Zaeh, M. F.
A1  - Mueller, N.
A1  - Lämmer, Anne
A1  - Andresen, Katja
T1  - Tools zur Ermittlung der Wandlungsfähigkeit
Y1  - 2006
ER  -