TY  - JOUR
A1  - Nikolaus, Jörg
A1  - Czapla, Sylvia
A1  - Möllnitz, Kristian
A1  - Höfer, Chris T.
A1  - Herrmann, Andreas
A1  - Wessig, Pablo
A1  - Müller, Peter
T1  - New molecular rods - Characterization of their interaction with membranes
JF  - Biochimica et biophysica acta : Biomembranes
N2  - Molecular rods are synthetical molecules consisting of a hydrophobic backbone which are functionalized with varying terminal groups. Here, we report on the interaction of a recently described new class of molecular rods with lipid and biological membranes. In order to characterize this interaction, different fluorescently labeled rods were synthesized allowing for the application of fluorescence spectroscopy and microscopy based approaches. Our data show that the rods are incorporated into membranes with a perpendicular orientation to the membrane surface and enrich preferentially in liquid-disordered lipid domains. These characteristics underline that rods can be applied as stable membrane-associated anchors for functionalizing membrane surfaces.
KW  - Molecular rod
KW  - Phospholipid
KW  - Lipid domain
KW  - Spiro compound
Y1  - 2011
U6  - https://doi.org/10.1016/j.bbamem.2011.08.008
SN  - 0005-2736
VL  - 1808
IS  - 12
SP  - 2781
EP  - 2788
PB  - Elsevier
CY  - Amsterdam
ER  -