TY - JOUR A1 - Arnold, Anne A1 - Nikoloski, Zoran T1 - A quantitative comparison of Calvin-Benson cycle models JF - Trends in plant science N2 - The Calvin-Benson cycle (CBC) provides the precursors for biomass synthesis necessary for plant growth. The dynamic behavior and yield of the CBC depend on the environmental conditions and regulation of the cellular state. Accurate quantitative models hold the promise of identifying the key determinants of the tightly regulated CBC function and their effects on the responses in future climates. We provide an integrative analysis of the largest compendium of existing models for photosynthetic processes. Based on the proposed ranking, our framework facilitates the discovery of best-performing models with regard to metabolomics data and of candidates for metabolic engineering. Y1 - 2011 U6 - https://doi.org/10.1016/j.tplants.2011.09.004 SN - 1360-1385 VL - 16 IS - 12 SP - 676 EP - 683 PB - Elsevier CY - London ER - TY - JOUR A1 - Beta, Carsten A1 - Bodenschatz, Eberhard T1 - Microfluidic tools for quantitative studies of eukaryotic chemotaxis JF - European journal of cell biology N2 - Over the past decade, microfluidic techniques have been established as a versatile platform to perform live cell experiments under well-controlled conditions. To investigate the directional responses of cells, stable concentration profiles of chemotactic factors can be generated in microfluidic gradient mixers that provide a high degree of spatial control. However, the times for built-up and switching of gradient profiles are in general too slow to resolve the intracellular protein translocation events of directional sensing of eukaryotes. Here, we review an example of a conventional microfluidic gradient mixer as well as the novel flow photolysis technique that achieves an increased temporal resolution by combining the photo-activation of caged compounds with the advantages of microfluidic chambers. KW - Eukaryotic chemotaxis KW - Dictyostelium discoideum KW - Microfluidics KW - Caged compounds KW - Numerical simulations Y1 - 2011 U6 - https://doi.org/10.1016/j.ejcb.2011.05.006 SN - 0171-9335 VL - 90 IS - 10 SP - 811 EP - 816 PB - Elsevier CY - Jena ER - TY - JOUR A1 - Blaum, Niels A1 - Mosner, Eva A1 - Schwager, Monika A1 - Jeltsch, Florian T1 - How functional is functional?Ecological groupings in terrestrial animal ecology - towards an animal functional type approach JF - Biodiversity and conservation N2 - Understanding mechanisms to predict changes in plant and animal communities is a key challenge in ecology. The need to transfer knowledge gained from single species to a more generalized approach has led to the development of categorization systems where species' similarities in life strategies and traits are classified into ecological groups (EGs) like functional groups/types or guilds. While approaches in plant ecology undergo a steady improvement and refinement of methodologies, progression in animal ecology is lagging behind. With this review, we aim to initiate a further development of functional classification systems in animal ecology, comparable to recent developments in plant ecology. We here (i) give an overview of terms and definitions of EGs in animal ecology, (ii) discuss existing classification systems, methods and application areas of EGs (focusing on terrestrial vertebrates), and (iii) provide a "roadmap towards an animal functional type approach" for improving the application of EGs and classifications in animal ecology. We found that an animal functional type approach requires: (i) the identification of core traits describing species' dependency on their habitat and life history traits, (ii) an optimization of trait selection by clustering traits into hierarchies, (iii) the assessment of "soft traits" as substitute for hardly measurable traits, e.g. body size for dispersal ability, and (iv) testing of delineated groups for validation including experiments. KW - Ecological classification KW - Functional type KW - Guild KW - Functional trait KW - Trait selection KW - Effect group KW - Response group KW - Environmental relationships Y1 - 2011 U6 - https://doi.org/10.1007/s10531-011-9995-1 SN - 0960-3115 VL - 20 IS - 11 SP - 2333 EP - 2345 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Blenau, Wolfgang A1 - Thamm, Markus T1 - Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies lessons from Drosophila melanogaster and Apis mellifera JF - Arthropod structure & development N2 - The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and modulating various physiological and behavioral processes in both protostomes and deuterostomes. The specific functions of serotonin are mediated by its binding to and subsequent activation of membrane receptors. The vast majority of these receptors belong to the superfamily of G-protein-coupled receptors. We report here the in vivo expression pattern of a recently characterized 5-HT(1) receptor of the honeybee Apis mellifera (Am5-HT(1A)) in the mushroom bodies. In addition, we summarize current knowledge on the distribution of serotonin and serotonin receptor subtypes in the brain and specifically in the mushroom bodies of the fruit fly Drosophila melanogaster and the honeybee. Functional studies in these two species have shown that serotonergic signaling participates in various behaviors including aggression, sleep, circadian rhythms, responses to visual stimuli, and associative learning. The molecular, pharmacological, and functional properties of identified 5-HT receptor subtypes from A. mellifera and D. melanogaster will also be summarized in this review. KW - Apis mellifera KW - G-protein-coupled receptor KW - Drosophila melanogaster KW - Mushroom body KW - Serotonin Y1 - 2011 U6 - https://doi.org/10.1016/j.asd.2011.01.004 SN - 1467-8039 VL - 40 IS - 5 SP - 381 EP - 394 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Chaykovska, Lyubov A1 - Tsuprykov, Oleg A1 - Hocher, Berthold T1 - Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy JF - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion N2 - The mortality of end-stage renal disease (ESRD) patients on dialysis remains high despite great improvement of dialysis technologies in the past decades. These patients die due to infectious diseases (mainly sepsis), cardiovascular diseases such as myocardial infarction, heart failure, stroke, and, in particular, sudden cardiac death. End stage renal disease is a complex condition, where the failure of kidney function is accompanied by numerous metabolic changes affecting almost all organ systems of the human body. Many of the biomarker characteristics of the individually affected organ systems have been associated with adverse outcomes. These biomarkers are different in patients with ESRD compared to the general population in the prediction of morbidity and mortality. Biomarker research in this field should aim to identify patients at risk for the different disease entities. Traditional biomarkers such as CRP, BNP, and troponins as well as new biomarkers such as fetuin, CD 154, and relaxin were analyzed in patients on dialysis. We will include observational as well as prospective clinical trials in this review. Furthermore, we will also discuss proteomics biomarker studies. The article assess the potential diagnostic value of different biomarkers in daily clinical practice as well as their usefulness for clinical drug development in end stage renal disease patients. Y1 - 2011 SN - 1433-6510 VL - 57 IS - 7-8 SP - 455 EP - 467 PB - Clin Lab Publ., Verl. Klinisches Labor CY - Heidelberg ER - TY - JOUR A1 - Dimigen, Olaf A1 - Sommer, Werner A1 - Hohlfeld, Annette A1 - Jacobs, Arthur M. A1 - Kliegl, Reinhold T1 - Coregistration of eye movements and EEG in natural reading analyses and review JF - Journal of experimental psychology : General N2 - Brain-electric correlates of reading have traditionally been studied with word-by-word presentation, a condition that eliminates important aspects of the normal reading process and precludes direct comparisons between neural activity and oculomotor behavior. In the present study, we investigated effects of word predictability on eye movements (EM) and fixation-related brain potentials (FRPs) during natural sentence reading. Electroencephalogram (EEG) and EM (via video-based eye tracking) were recorded simultaneously while subjects read heterogeneous German sentences, moving their eyes freely over the text. FRPs were time-locked to first-pass reading fixations and analyzed according to the cloze probability of the currently fixated word. We replicated robust effects of word predictability on EMs and the N400 component in FRPs. The data were then used to model the relation among fixation duration, gaze duration, and N400 amplitude, and to trace the time course of EEG effects relative to effects in EM behavior. In an extended Methodological Discussion section, we review 4 technical and data-analytical problems that need to be addressed when FRPs are recorded in free-viewing situations (such as reading, visual search, or scene perception) and propose solutions. Results suggest that EEG recordings during normal vision are feasible and useful to consolidate findings from EEG and eye-tracking studies. KW - EEG KW - eye tracking KW - fixation-related potentials KW - artifact correction KW - natural viewing Y1 - 2011 U6 - https://doi.org/10.1037/a0023885 SN - 0096-3445 VL - 140 IS - 4 SP - 552 EP - 572 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Eckstein, Lars T1 - Agnew, V., Enlightenment Orpheus: the Power of Music in Other Worlds; New York, Oxford Univ. Press, 2008 BT - Enlightenment Orpheus: the Power of Music in Other Worlds Y1 - 2011 ER - TY - JOUR A1 - Eckstein, Lars T1 - Carrington, B., Sport and Politics: the Sporting Black Diaspora; London, Sage, 2010 BT - Race, Sport and Politics: the Sporting Black Diaspora Y1 - 2011 ER - TY - JOUR A1 - Feinberg, Anat T1 - Peter W. Marx, Ein theatralisches Zeitalter : Bürgerliche Selbstinszenierungen um 1900 / [rezensiert von] Anat Feinberg JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. N2 - rezensiertes Werk: Marx, Peter W.:Ein theatralisches Zeitalter : Bürgerliche Selbstinszenierungen um 1900. - Tübingen [u.a.] : A. Francke, 2008. - 429 S. ISBN 978-3-772-08220-7 Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53550 SN - 1614-6492 SN - 1862-7684 IS - 17 SP - 284 EP - 285 ER - TY - JOUR A1 - Fischer, Martin H. A1 - Brugger, Peter T1 - When digits help digits spatial-numerical associations point to finger counting as prime example of embodied cognition JF - Frontiers in psychology N2 - Spatial numerical associations (SNAs) are prevalent yet their origin is poorly understood. We first consider the possible prime role of reading habits in shaping SNAs and list three observations that argue against a prominent influence of this role: (1) directional reading habits for numbers may conflict with those for non-numerical symbols, (2) short-term experimental manipulations can overrule the impact of decades of reading experience, (3) SNAs predate the acquisition of reading. As a promising alternative, we discuss behavioral, neuroscientific, and neuropsychological evidence in support of finger counting as the most likely initial determinant of SNAs. Implications of this "manumerical cognition" stance for the distinction between grounded, embodied, and situated cognition are discussed. KW - embodied cognition KW - finger counting KW - numerical cognition Y1 - 2011 U6 - https://doi.org/10.3389/fpsyg.2011.00260 SN - 1664-1078 VL - 2 PB - Frontiers Research Foundation CY - Lausanne ER -