TY  - JOUR
A1  - Prokopovic, Vladimir Z.
A1  - Duschl, Claus
A1  - Volodkin, Dmitry
T1  - Hyaluronic Acid/Poly-l-Lysine Multilayers as Reservoirs for Storage and Release of Small Charged Molecules
JF  - Macromolecular bioscience
N2  - Polyelectrolyte multilayer films are nowadays very attractive for bioapplications due to their tunable properties and ability to control cellular response. Here we demonstrate that multilayers made of hyaluronic acid and poly-l-lysine act as high-capacity reservoirs for small charged molecules. Strong accumulation within the film is explained by electrostatically driven binding to free charges of polyelectrolytes. Binding and release mechanisms are discussed based on charge balance and polymer dynamics in the film. Our results show that transport of molecules through the film-solution interface limits the release rate. The multilayers might serve as an effective platform for drug delivery and tissue engineering due to high potential for drug loading and controlled release.
KW  - diffusion
KW  - drug delivery
KW  - dye
KW  - release mechanism
Y1  - 2015
U6  - https://doi.org/10.1002/mabi.201500093
SN  - 1616-5187
SN  - 1616-5195
VL  - 15
IS  - 10
SP  - 1357
EP  - 1363
PB  - Wiley-VCH
CY  - Weinheim
ER  -