TY  - JOUR
A1  - Mutai, Peggoty
A1  - Heydenreich, Matthias
A1  - Thoithi, Grace
A1  - Mugumbate, Grace
A1  - Chibale, Kelly
A1  - Yenesew, Abiy
T1  - 3-Hydroxyisoflavanones from the stem bark of dalbergia melanoxylon -  isolation, antimycobacterial evaluation and molecular docking studies
JF  - Phytochemistry letters
N2  - Two new 3-hydroxyisoflavanones, (S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2',7-dimethoxy-2 '',2 ''-dimethylpyrano[5 '',6 '':3',4']isoflavanone (trivial name sophoronol-7-methyl ether) along with two known compounds (dalbergin and formononetin) were isolated from the stem bark of Dalbergia melanoxylon. The structures were elucidated using spectroscopic techniques. Kenusanone F 7-methyl ether showed activity against Mycobacterium tuberculosis, whereas both of the new compounds were inactive against the malaria parasite Plasmodium falciparum at 10 mu g/ml. Docking studies showed that the new compounds kenusanone F 7-methyl ether and sophoronol-7-methyl ether have high affinity for the M. tuberculosis drug target INHA.
KW  - Dalbergia melanoxylon
KW  - 3-Hydroxyisoflavanone
KW  - Kenusanone F 7-methyl ether
KW  - Sophoronol-7-methyl ether
KW  - Mycobacterium tuberculosis
KW  - Docking
Y1  - 2013
U6  - https://doi.org/10.1016/j.phytol.2013.08.018
SN  - 1874-3900
SN  - 1876-7486
VL  - 6
IS  - 4
SP  - 671
EP  - 675
PB  - Elsevier
CY  - Amsterdam
ER  -