TY  - JOUR
A1  - Rosencrantz, Sophia
A1  - Tang, Jo Sing Julia
A1  - Schulte-Osseili, Christine
A1  - Böker, Alexander
A1  - Rosencrantz, Ruben R.
T1  - Glycopolymers by RAFT Polymerization as Functional Surfaces for Galectin-3
JF  - Macromolecular chemistry and physics
N2  - Glycan-protein interactions are essential biological processes with many disease-related modulations and variations. One of the key proteins involved in tumor progression and metastasis is galectin-3 (Gal-3). A lot of effort is put into the development of Gal-3 inhibitors as new therapeutic agents. The avidity of glycan-protein interactions is strongly enhanced by multivalent ligand presentation. Multivalent presentation of glycans can be accomplished by utilizing glycopolymers, which are polymers with pendent glycan groups. For the production of glycopolymers, glycomonomers are synthesized by a regioselective, microwave-assisted approach starting from lactose. The resulting methacrylamide derivatives are polymerized by RAFT and immobilized on gold surfaces using the trithiocarbonate group of the chain transfer agent. Surface plasmon resonance spectroscopy enables the label free kinetic characterization of Gal-3 binding to these multivalent glycopolymers. The measurements indicate oligomerization of Gal-3 upon exposure to multivalent environments and reveal strong specific interaction with the immobilized polymers.
KW  - galectin-3
KW  - glycopolymers
KW  - multivalency
KW  - RAFT
KW  - surface plasmon resonance
Y1  - 2019
U6  - https://doi.org/10.1002/macp.201900293
SN  - 1022-1352
SN  - 1521-3935
VL  - 220
IS  - 20
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - GEN
A1  - Zimmermann, Marc
A1  - Stomps, Benjamin René Harald
A1  - Schulte-Osseili, Christine
A1  - Grigoriev, Dmitry
A1  - Ewen, Dirk
A1  - Morgan, Andrew
A1  - Böker, Alexander
T1  - Organic dye anchor peptide conjugates as an advanced coloring agent for polypropylene yarn
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Polypropylene as one of the world's top commodity polymers is also widely used in the textile industry. However, its non-polar nature and partially crystalline structure significantly complicate the process of industrial coloring of polypropylene. Currently, textiles made of polypropylene or with a significant proportion of polypropylene are dyed under quite harsh conditions, including the use of high pressures and temperatures, which makes this process energy intensive. This research presents a three-step synthesis of coloring agents, capable of adhering onto synthetic polypropylene yarns without harsh energy-consuming conditions. This is possible by encapsulation of organic pigments using trimethoxyphenylsilane, introduction of surface double bonds via modification of the silica shell with trimethoxysilylpropylmethacrylate and final attachment of highly adhesive anchor peptides using thiol-ene chemistry. We demonstrate the applicability of this approach by dyeing polypropylene yarns in a simple process under ambient conditions after giving a step-by-step guide for the synthesis of these new dyeing agents. Finally, the successful dyeing of the yarns is visualized, and its practicability is discussed.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1380 
KW  - anchor peptides
KW  - organic dye pigments
KW  - coloring agents
KW  - polypropylene yarns
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-548913
SN  - 1866-8372
IS  - 1-2
ER  - 
TY  - JOUR
A1  - Zimmermann, Marc
A1  - Stomps, Benjamin René Harald
A1  - Schulte-Osseili, Christine
A1  - Grigoriev, Dmitry
A1  - Ewen, Dirk
A1  - Morgan, Andrew
A1  - Böker, Alexander
T1  - Organic dye anchor peptide conjugates as an advanced coloring agent for polypropylene yarn
JF  - Textile Research Journal
N2  - Polypropylene as one of the world's top commodity polymers is also widely used in the textile industry. However, its non-polar nature and partially crystalline structure significantly complicate the process of industrial coloring of polypropylene. Currently, textiles made of polypropylene or with a significant proportion of polypropylene are dyed under quite harsh conditions, including the use of high pressures and temperatures, which makes this process energy intensive. This research presents a three-step synthesis of coloring agents, capable of adhering onto synthetic polypropylene yarns without harsh energy-consuming conditions. This is possible by encapsulation of organic pigments using trimethoxyphenylsilane, introduction of surface double bonds via modification of the silica shell with trimethoxysilylpropylmethacrylate and final attachment of highly adhesive anchor peptides using thiol-ene chemistry. We demonstrate the applicability of this approach by dyeing polypropylene yarns in a simple process under ambient conditions after giving a step-by-step guide for the synthesis of these new dyeing agents. Finally, the successful dyeing of the yarns is visualized, and its practicability is discussed.
KW  - anchor peptides
KW  - organic dye pigments
KW  - coloring agents
KW  - polypropylene
KW  - yarns
Y1  - 2020
U6  - https://doi.org/10.1177/0040517520932231
SN  - 0040-5175
SN  - 1746-7748
VL  - 91
IS  - 1-2
SP  - 28
EP  - 39
PB  - Sage Publ.
CY  - London
ER  -