TY  - JOUR
A1  - Teixeira, C. V.
A1  - Blanzat, Muriel
A1  - Koetz, Joachim
A1  - Rico-Lattes, I.
A1  - Brezesinski, Gerald
T1  - In-plane miscibility and mixed bilayer microstructure in mixtures of catanionic glycolipids and zwitterionic phospholipids
JF  - Biochimica et biophysica acta : Biomembranes
N2  - SAXS/WAXS studies were performed in combination with freeze fracture electron microscopy using mixtures of a new Gemini catanionic surfactant (Gem 16-12, formed by two sugar groups bound by a hydrocarbon spacer with 12 carbons and two 16-carbon chains) and the zwitterionic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine(DPPC) to establish the phase diagram. Gem 16-12 in water forms bilayers with the same amount of hydration water as DPPC. A frozen interdigitated phase with a low hydration number is observed below room temperature. The kinetics of the formation of this crystalline phase is very slow. Above the chain melting temperature, multilayered vesicles are formed. Mixing with DPPC produces mixed bilayers above the corresponding chain melting temperature. At room temperature, partially lamellar aggregates with local nematic order are observed. Splitting of infinite lamellae into discs is linked to immiscibility in frozen state. The ordering process is always accompanied by dehydration of the system. As a consequence, an unusual order-disorder phase transition upon cooling is observed.
KW  - SAXS
KW  - bilayer
KW  - gemini surfactant
KW  - ordering process
KW  - Anti-HIV
KW  - miscibility
Y1  - 2006
U6  - https://doi.org/10.1016/j.bbamem.2006.05.025
SN  - 0005-2736
VL  - 1758
SP  - 1797
EP  - 1808
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Perez-Anes, Alexandra
A1  - Rodrigues, Fernanda
A1  - Caminade, Anne-Marie
A1  - Stefaniu, Cristina
A1  - Tiersch, Brigitte
A1  - Turrin, Cedric-Olivier
A1  - Blanzat, Muriel
T1  - Influence of structural parameters on the self-association properties of anti-HIV catanionic dendrimers
JF  - ChemPhysChem : a European journal of chemical physics and physical chemistry
N2  - The self-association properties of anti-HIV catanionic dendrimers as multivalent galactosylceramide (GalCer)-derived inhibitors are presented. The study was designed to elucidate the origin of the relatively high cytotoxicity values of these antiHIV catanionic dendrimers, which have previously been found to exhibit in vitro anti-HIV activity in the submicromolar range. The physicochemical properties of these catanionic dendrimers were studied to tentatively correlate the structural parameters with self-association and biological properties. We can conclude from this study that the absence of correlation between the hydrophobicity and the cytotoxicity of the catanionic systems could be explained by the partial segregation of the different partners of the catanionic entities.
KW  - anti-HIV
KW  - catanionic surfactants
KW  - dendrimers
KW  - galactosylceramide
KW  - glycolipids
Y1  - 2015
U6  - https://doi.org/10.1002/cphc.201500484
SN  - 1439-4235
SN  - 1439-7641
VL  - 16
IS  - 16
SP  - 3433
EP  - 3437
PB  - Wiley-VCH
CY  - Weinheim
ER  -