TY  - JOUR
A1  - Juma, Wanyama P.
A1  - Akala, Hoseah M.
A1  - Eyase, Fredrick L.
A1  - Muiva, Lois M.
A1  - Heydenreich, Matthias
A1  - Okalebo, Faith A.
A1  - Gitu, Peter M.
A1  - Peter, Martin G.
A1  - Walsh, Douglas S.
A1  - Imbuga, Mabel
A1  - Yenesew, Abiy
T1  - Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea
JF  - Phytochemistry letters
N2  - The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.
KW  - Tephrosia purpurea
KW  - Leguminosae
KW  - Stem
KW  - Flavone
KW  - Terpurinflavone
KW  - Antiplasmodial
Y1  - 2011
U6  - https://doi.org/10.1016/j.phytol.2011.02.010
SN  - 1874-3900
VL  - 4
IS  - 2
SP  - 176
EP  - 178
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Csütörtöki, Renáta
A1  - Szatmári, István
A1  - Koch, Andreas
A1  - Heydenreich, Matthias
A1  - Kleinpeter, Erich
A1  - Fulop, Ferenc
T1  - Synthesis and conformational analysis of new naphth[1,2-e][1,3]oxazino[3,4-c]quinazoline derivatives
Y1  - 2011
SN  - 0040-4020
ER  - 
TY  - JOUR
A1  - Csuetoertoeki, Renata
A1  - Szatmari, Istvan
A1  - Koch, Andreas
A1  - Heydenreich, Matthias
A1  - Kleinpeter, Erich
A1  - Fueloep, Ferenc
T1  - Synthesis and conformational analysis of new naphth[1,2-e][1,3]oxazino[3,4-c]quinazoline derivatives
JF  - Tetrahedron
N2  - A new highly functionalized aminonaphthol derivative, 1-(amino(2-aminophenyl)methyl)-2-naphthol (4), was synthesized by the reaction of 2-naphthol, 2-nitrobenzaldehyde and tert-butyl carbamate or benzyl carbamate, followed by reduction and/or removal of the protecting group. The aminonaphthol derivative thus obtained was converted in ring-closure reactions with formaldehyde. benzaldehyde and/or phosgene to the corresponding naphth[1,2-e][1,3]oxazino[3,4-c]quinazoline derivatives. The conformational analysis of some derivatives by NMR spectroscopy and accompanying molecular modelling are also reported.
KW  - Naphthoxazinoquinazolines
KW  - NMR
KW  - Conformational analysis
KW  - DFT calculations
KW  - Hammett-Brown plots
Y1  - 2011
U6  - https://doi.org/10.1016/j.tet.2011.08.074
SN  - 0040-4020
VL  - 67
IS  - 44
SP  - 8564
EP  - 8571
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Marsat, Jean-Noel
A1  - Heydenreich, Matthias
A1  - Kleinpeter, Erich
A1  - Berlepsch, Hans V.
A1  - Boettcher, Christoph
A1  - Laschewsky, André
T1  - Self-Assembly into multicompartment micelles and selective solubilization by Hydrophilic-Lipophilic-Fluorophilic block copolymers
JF  - Macromolecules : a publication of the American Chemical Society
N2  - Amphiphilic linear ternary block copolymers (ABC) were synthesized in three consecutive steps by the reversible addition fragmentation chain transfer (RAFT) method. Using oligo(ethylene oxide) monomethyl ether acrylate, benzyl acrylate, and 1H,1H-perfluorobutyl acrylate monomers, the triblock copolymers consist of a hydrophilic (A), a lipophilic (B), and a fluorophilic (C) block. The block sequence of the triphilic copolymers was varied systematically to provide all possible variations: ABC, ACB, and BAC. All blocks have glass transition temperatures below 0 degrees C. Self-assembly into spherical micellar aggregates was observed in aqueous solution, where hydrophobic cores undergo local phase separation into various ultrastructures as shown by cryogenic transmission electron microscopy (cryo-TEM). Selective solubilization of substantial quantities of hydrocarbon and fluorocarbon low molar mass compounds by the lipophilic and fluorophilic block, respectively, is demonstrated.
Y1  - 2011
U6  - https://doi.org/10.1021/ma200032j
SN  - 0024-9297
VL  - 44
IS  - 7
SP  - 2092
EP  - 2105
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Kleinpeter, Erich
A1  - Marsat, Jean-Noël
A1  - Heydenreich, Matthias
A1  - von Berlepsch, Hans
A1  - Laschewsky, André
T1  - Self-Assembly into Multicompartment Micelles and Selective Solubilization by Hydrophilic-Lipophilic- Fluorophilic Block Copolymers
Y1  - 2011
SN  - 0024-9297
ER  -