TY - JOUR A1 - Shave, Rob A1 - Baggish, Aaron A1 - George, Keith A1 - Wood, Malissa A1 - Scharhag, Jürgen A1 - Whyte, Gregory A1 - Gaze, David A1 - Thompson, Paul D. T1 - Exercise : induced cardiac troponin elevation evidence, mechanisms, and implications N2 - Regular physical exercise is recommended for the primary prevention of cardiovascular disease. Although the high prevalence of physical inactivity remains a formidable public health issue, participation in exercise programs and recreational sporting events, such as marathons and triathlons, is on the rise. Although regular exercise training reduces cardiovascular disease risk, recent studies have documented elevations in cardiac troponin (cTn) consistent with cardiac damage after bouts of exercise in apparently healthy individuals. At present, the prevalence, mechanism(s), and clinical significance of exercise-induced cTn release remains incompletely understood. This paper will review the biochemistry, prevalence, potential mechanisms, and management of patients with exercise-induced cTn elevations. (J Am Coll Cardiol 2010; 56: 169-76) Y1 - 2010 UR - http://content.onlinejacc.org/ U6 - https://doi.org/10.1016/j.jacc.2010.03.037 SN - 0735-1097 ER -