TY  - CHAP
A1  - Miettinen, Markus S.
A1  - Monticelli, Luca
A1  - Nedumpully-Govindan, Praveen
A1  - Knecht, Volker
A1  - Ignatova, Zoya
T1  - Initiating polyglutamine aggregation - computational clarification of the structural details
T2  - Biophysical journal
Y1  - 2015
SN  - 0006-3495
SN  - 1542-0086
VL  - 108
IS  - 2
SP  - 386A
EP  - 386A
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Valleriani, Angelo
A1  - Zhang, Gong
A1  - Nagar, Apoorva
A1  - Ignatova, Zoya
A1  - Lipowsky, Reinhard
T1  - Length-dependent translation of messenger RNA by ribosomes
JF  - Physical review : E, Statistical, nonlinear and soft matter physics
N2  - A simple measure for the efficiency of protein synthesis by ribosomes is provided by the steady state amount of protein per messenger RNA (mRNA), the so-called translational ratio, which is proportional to the translation rate. Taking the degradation of mRNA into account, we show theoretically that both the translation rate and the translational ratio decrease with increasing mRNA length, in agreement with available experimental data for the prokaryote Escherichia coli. We also show that, compared to prokaryotes, mRNA degradation in eukaryotes leads to a less rapid decrease of the translational ratio. This finding is consistent with the fact that, compared to prokaryotes, eukaryotes tend to have longer proteins.
Y1  - 2011
U6  - https://doi.org/10.1103/PhysRevE.83.042903
SN  - 1539-3755
VL  - 83
IS  - 4
PB  - American Physical Society
CY  - College Park
ER  -