TY  - JOUR
A1  - Zupok, Arkadiusz
A1  - Iobbi-Nivol, Chantal
A1  - Mejean, Vincent
A1  - Leimkühler, Silke
T1  - The regulation of Moco biosynthesis and molybdoenzyme gene expression by molybdenum and iron in bacteria
JF  - Metallomics : integrated biometal science
N2  - Bacterial molybdoenzymes are key enzymes involved in the global sulphur, nitrogen and carbon cycles. These enzymes require the insertion of the molybdenum cofactor (Moco) into their active sites and are able to catalyse a large range of redox-reactions. Escherichia coli harbours nineteen different molybdoenzymes that require a tight regulation of their synthesis according to substrate availability, oxygen availability and the cellular concentration of molybdenum and iron. The synthesis and assembly of active molybdoenzymes are regulated at the level of transcription of the structural genes and of translation in addition to the genes involved in Moco biosynthesis. The action of global transcriptional regulators like FNR, NarXL/QP, Fur and ArcA and their roles on the expression of these genes is described in detail. In this review we focus on what is known about the molybdenum- and iron-dependent regulation of molybdoenzyme and Moco biosynthesis genes in the model organism E. coli. The gene regulation in E. coli is compared to two other well studied model organisms Rhodobacter capsulatus and Shewanella oneidensis.
Y1  - 2019
U6  - https://doi.org/10.1039/c9mt00186g
SN  - 1756-5901
SN  - 1756-591X
VL  - 11
IS  - 10
SP  - 1602
EP  - 1624
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -