TY  - JOUR
A1  - de Vinuesa, Amaya Garcia
A1  - Abdelilah-Seyfried, Salim
A1  - Knaus, Petra
A1  - Zwijsen, An
A1  - Bailly, Sabine
T1  - BMP signaling in vascular biology and dysfunction
JF  - New journal of physics : the open-access journal for physics
N2  - The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved.
KW  - Bone morphogenetic proteins (BMP)
KW  - Signaling
KW  - Vasculature
KW  - Development
KW  - Disease
Y1  - 2016
U6  - https://doi.org/10.1016/j.cytogfr.2015.12.005
SN  - 1359-6101
SN  - 1879-0305
VL  - 27
SP  - 65
EP  - 79
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Haack, Timm
A1  - Abdelilah-Seyfried, Salim
T1  - The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
JF  - Development : Company of Biologists
N2  - Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.
KW  - Endocardium
KW  - Cardiac development
KW  - Hemodynamics
KW  - Bmp
KW  - Kruppel-like factor 2
KW  - Vegf
KW  - Mechanotransduction
KW  - Zebrafish
KW  - Mouse
Y1  - 2016
U6  - https://doi.org/10.1242/dev.131425
SN  - 0950-1991
SN  - 1477-9129
VL  - 143
SP  - 373
EP  - 386
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Paolini, Alessio
A1  - Abdelilah-Seyfried, Salim
T1  - The mechanobiology of zebrafish cardiac valve leaflet formation
JF  - Current opinion in cell biology : review articles, recommended reading, bibliography of the world literature
N2  - Over a lifetime, rhythmic contractions of the heart provide a continuous flow of blood throughout the body. An essential morphogenetic process during cardiac development which ensures unidirectional blood flow is the formation of cardiac valves. These structures are largely composed of extracellular matrix and of endocardial cells, a specialized population of endothelial cells that line the interior of the heart and that are subjected to changing hemodynamic forces. Recent studies have significantly expanded our understanding of this morphogenetic process. They highlight the importance of the mechanobiology of cardiac valve formation and show how biophysical forces due to blood flow drive biochemical and electrical signaling required for the differentiation of cells to produce cardiac valves.
Y1  - 2018
U6  - https://doi.org/10.1016/j.ceb.2018.05.007
SN  - 0955-0674
SN  - 1879-0410
VL  - 55
SP  - 52
EP  - 58
PB  - Elsevier
CY  - London
ER  -