TY  - JOUR
A1  - Wolf, Isabell Ann-Cathrin
A1  - Gilles, Maria
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Seibert, Julia
A1  - Jennen-Steinmetz, Christine
A1  - Krumm, Bertram
A1  - Rietschel, Marcella
A1  - Deuschle, Michael
A1  - Laucht, Manfred
T1  - Impact of prenatal stress on mother-infant dyadic behavior during the still-face paradigm
JF  - Borderline Personality Disorder and Emotion Dysregulation : the official journal of the National Education Alliance for Borderline Personality Disorder (NEA.BPD) and Dachverband Dialektisch Behaviorale Therapie (DDBT)
N2  - Background:
Mother-infant interaction provides important training for the infant’s ability to cope with stress and the development of resilience. Prenatal stress (PS) and its impact on the offspring’s development have long been a focus of stress research, with studies highlighting both harmful and beneficial effects. The aim of the current study was to examine the possible influence of both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy with mother-child dyadic behavior following stress exposure.
Methods:
The behavior of 164 mother-infant dyads during the still-face situation was filmed at six months postpartum and coded into three dyadic patterns: 1) both positive, 2) infant protesting-mother positive, and 3) infant protesting-mother negative. PS exposure was assessed prenatally according to psychological measures (i.e., psychopathological, perceived and psychosocial PS; n = 164) and HPA axis activity measures (maternal salivary cortisol, i.e., cortisol decline and area under the curve with respect to ground (AUCg); n = 134).
Results:
Mother-infant dyads in both the high- and low-stress groups showed decreasing positive and increasing negative dyadic behavior in the reunion episode, which is associated with the well-known “still-face” and “carry-over” effect. Furthermore, mother-infant dyads with higher psychosocial PS exhibited significantly more positive dyadic behavior than the low psychosocial PS group in the first play episode, but not in the reunion episode. Similarly, mother-infant dyads with high HPA axis activity (i.e. high AUCg) but steeper diurnal cortisol decline (i.e. cortisol decline) displayed significantly less negative behavior in the reunion episode than dyads with low HPA axis activity. No significant results were found for psychopathological stress and perceived stress.
Conclusions:
The results suggest a beneficial effect of higher psychosocial PS and higher prenatal maternal HPA axis activity in late gestation, which is in line with “stress inoculation” theories.
KW  - Prenatal stress
KW  - Face-to-face still-face paradigm
KW  - Resilience
KW  - Psychosocial stress
KW  - Cortisol
Y1  - 2018
U6  - https://doi.org/10.1186/s40479-018-0078-8
SN  - 2051-6673
VL  - 5
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Bender, Stephan
A1  - Banaschewski, Tobias
A1  - Rößner, Veit
A1  - Klein, Christoph
A1  - Rietschel, Marcella
A1  - Feige, Bernd
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Variability of single trial brain activation predicts fluctuations in reaction time
JF  - Biological psychology
N2  - Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power).
 We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors.
 Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype.
 We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability. (C) 2015 Elsevier B.V. All rights reserved.
KW  - Event related potential
KW  - Haplotype
KW  - Intertrial coherence
KW  - Topographic consistency
KW  - Low frequency amplitude variability
KW  - Psychosocial stress
Y1  - 2015
U6  - https://doi.org/10.1016/j.biopsycho.2015.01.013
SN  - 0301-0511
SN  - 1873-6246
VL  - 106
SP  - 50
EP  - 60
PB  - Elsevier
CY  - Amsterdam
ER  -