TY  - JOUR
A1  - Baumann, Otto
A1  - Dames, Petra
A1  - Kühnel, Dana
A1  - Walz, Bernd
T1  - Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach Periplaneta americana
Y1  - 2002
UR  - http://www.biomedcentral.com/1472-6793/2/9
ER  - 
TY  - JOUR
A1  - Baumann, Otto
A1  - Kühnel, Dana
A1  - Dames, Petra
A1  - Walz, Bernd
T1  - Dopaminergic and serotonergic innervation of cockroach salivary glands : distribution and morphology of synapses and release sites
N2  - The paired salivary glands in the cockroach are composed of acini with ion-transporting peripheral P-cells and protein-secreting central C-cells, and a duct system for the modification of the primary saliva. Secretory activity is controlled by serotonergic and dopaminergic neurons, whose axons form a dense plexus on the glands. The spatial relationship of release sites for serotonin and dopamine to the various cell types was determined by anti-synapsin immunofluorescence confocal microscopy and electron microscopy. Every C-cell apparently has only serotonergic synapses on its surface. Serotonergic and dopaminergic fibres on the acini have their release zones at a distance of similar to0.5 mum from the P-cells. Nerves between acinar lobules may serve as neurohaemal organs and contain abundant dopaminergic and few serotonergic release sites. Some dopaminergic and serotonergic release sites reside in the duct epithelium, the former throughout the duct system, the latter only in segments next to acini. These findings are consistent with the view that C-cells respond exclusively to serotonin, P-cells to serotonin and dopamine, and most duct cells only to dopamine. Moreover, the data suggest that C-cells are stimulated by serotonin released close to their surface, whereas P-cells and most duct cells are exposed to serotonin/dopamine liberated at some distance
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Kühnel, Dana
A1  - Steinberg, Pablo
A1  - Scholtka, Bettina
T1  - A human-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) can induce precancerous lesions in rat intestine after 6 months of exposure
Y1  - 2004
SN  - 0028-1298
ER  -