TY - JOUR A1 - Newman, Abraham A1 - Debre, Maria Josepha A1 - Naylor, Tristen A1 - Regilme, Salvador Santino Fulo Regilme Jr. A1 - Viola, Lora Anne ED - Labrosse, Diane ED - Szarejko, Andrew ED - Fujii, George T1 - Lora Anne Viola. The closure of the international system: how institutions create political equalities and hierarchies. Cambridge: Cambridge University Press, 2020. ISBN: 9781108482257 (hardback, $99.99). JF - H-Diplo roundtable Y1 - 2022 UR - https://hdiplo.org/to/RT23-49 VL - XXIII IS - 49 PB - H-Net: Humanities & Social Sciences Online CY - East Lansing, MI ER - TY - JOUR A1 - Konigorski, Stefan A1 - Wernicke, Sarah A1 - Slosarek, Tamara A1 - Zenner, Alexander M. A1 - Strelow, Nils A1 - Ruether, Darius F. A1 - Henschel, Florian A1 - Manaswini, Manisha A1 - Pottbäcker, Fabian A1 - Edelman, Jonathan A. A1 - Owoyele, Babajide A1 - Danieletto, Matteo A1 - Golden, Eddye A1 - Zweig, Micol A1 - Nadkarni, Girish N. A1 - Böttinger, Erwin T1 - StudyU: a platform for designing and conducting innovative digital N-of-1 trials JF - Journal of medical internet research N2 - N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully functional platforms are not yet available. Here, we present the open source StudyU platform, which includes the StudyU Designer and StudyU app. With the StudyU Designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials. The StudyU app is a smartphone app with innovative user-centric elements for participants to partake in trials published through the StudyU Designer to assess the effects of different interventions on their health. Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner. We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice. KW - digital interventions KW - N-of-1 trial KW - SCED KW - single-case experimental design KW - web application KW - mobile application KW - app KW - digital health Y1 - 2022 U6 - https://doi.org/10.2196/35884 SN - 1439-4456 SN - 1438-8871 VL - 24 IS - 7 PB - Healthcare World CY - Richmond, Va. ER - TY - JOUR A1 - Omranian, Sara A1 - Nikoloski, Zoran A1 - Grimm, Dominik G. T1 - Computational identification of protein complexes from network interactions: Present state, challenges, and the way forward BT - present state, challenges, and the way forward JF - Computational and structural biotechnology journal N2 - Physically interacting proteins form macromolecule complexes that drive diverse cellular processes. Advances in experimental techniques that capture interactions between proteins provide us with protein-protein interaction (PPI) networks from several model organisms. These datasets have enabled the prediction and other computational analyses of protein complexes. Here we provide a systematic review of the state-of-the-art algorithms for protein complex prediction from PPI networks proposed in the past two decades. The existing approaches that solve this problem are categorized into three groups, including: cluster-quality-based, node affinity-based, and network embedding-based approaches, and we compare and contrast the advantages and disadvantages. We further include a comparative analysis by computing the performance of eighteen methods based on twelve well-established performance measures on four widely used benchmark protein-protein interaction networks. Finally, the limitations and drawbacks of both, current data and approaches, along with the potential solutions in this field are discussed, with emphasis on the points that pave the way for future research efforts in this field. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). KW - Protein Complex Prediction KW - Protein-Protein interaction network KW - Network KW - Clustering Algorithms KW - Network embedding Y1 - 2022 U6 - https://doi.org/10.1016/j.csbj.2022.05.049 SN - 2001-0370 VL - 20 SP - 2699 EP - 2712 PB - Research Network of Computational and Structural Biotechnology (RNCSB) CY - Gotenburg ER - TY - JOUR A1 - Lampart, Fabian T1 - Rezension zu: Per un atlante geostorico della letteratura tedesca (1900–1930) / Hrsg.: Francesco Fiorentino, Milena Massalongo, Gianluca Paolucci. - Roma: Istituto Italiano di Studi Germanici, 2021. - 326 S. - ISBN: 978-88-95868-56-1 JF - Studi Germanici Y1 - 2023 UR - https://www.studigermanici.it/wp-content/uploads/2023/06/SG23_Osservatorio.pdf SN - 0039-2952 VL - 2023 IS - 23 SP - 289 EP - 291 PB - Istituto Italiano di Studi Germanici CY - Rome ER - TY - JOUR A1 - Miklashevsky, Alex A1 - Kulkova, Elena A1 - Michirev, Alexej A1 - Jeglinski-Mende, Melinda A. A1 - Bertonatti, Matias T1 - Book review to: Raab, Markus: Judgment, decision-making, and embodied choices. - London ; San Diego ; Cambridge, MA ; Oxford: Academic Press, 2020. - xv, 155 pages. - ISBN: 978-0-12-823523-2 JF - Frontiers in psychology KW - embodied cognition KW - decision making KW - embodied choice KW - book review KW - mind-body Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.665728 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Apriyanto, Ardha A1 - Compart, Julia A1 - Fettke, Jörg T1 - A review of starch, a unique biopolymer - structure, metabolism and in planta modifications JF - Plant science : an international journal of experimental plant biology N2 - Starch is a complex carbohydrate polymer produced by plants and especially by crops in huge amounts. It consists of amylose and amylopectin, which have alpha-1,4-and alpha-1,6-linked glucose units. Despite this simple chemistry, the entire starch metabolism is complex, containing various (iso)enzymes/proteins. However, whose interplay is still not yet fully understood. Starch is essential for humans and animals as a source of nutrition and energy. Nowadays, starch is also commonly used in non-food industrial sectors for a variety of purposes. However, native starches do not always satisfy the needs of a wide range of (industrial) applications. This review summarizes the structural properties of starch, analytical methods for starch characterization, and in planta starch modifications. KW - starch KW - starch structure KW - starch surface KW - starch modifications; KW - analytics Y1 - 2022 U6 - https://doi.org/10.1016/j.plantsci.2022.111223 SN - 0168-9452 SN - 1873-2259 VL - 318 PB - Elsevier Science CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Turner, Bryan S. T1 - Book review: Populism in the civil sphere / edited: Jeffrey C. Alexander, Peter Kivisto, Giuseppe Sciortino. - Cambridge ; Medford : Polity, 2021. - ISBN 978-1-5095-4474-5 ; 978-1-5095-4473-8 JF - Journal of classical sociology : JCS Y1 - 2021 U6 - https://doi.org/10.1177/1468795X21996104 SN - 1468-795X SN - 1741-2897 VL - 21 IS - 3-4 SP - 357 EP - 360 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Stehle, Fee T1 - Rezension zu: Jordan, Andrew; Huitema, Dave; Asselt Harro van; Foster, Johanna (eds.): Governing climate change: polycentricity in action? - Cambridge ; New York, NY ; Port Melbourne : Cambridge University Press, 2018. - xv, 389 S. - ISBN 978-1-108-41812-6 JF - Global environmental politics Y1 - 2021 U6 - https://doi.org/10.1162/glep_r_00596 SN - 1536-0091 SN - 1526-3800 VL - 21 IS - 1 SP - 157 EP - 159 PB - MIT Press CY - Cambridge ER - TY - JOUR A1 - Oosthoek, Kris A1 - Doerr, Christian T1 - Cyber threat intelligence: A product without a process? JF - International journal of intelligence and counterintelligence Y1 - 2020 U6 - https://doi.org/10.1080/08850607.2020.1780062 SN - 0885-0607 SN - 1521-0561 VL - 34 IS - 2 SP - 300 EP - 315 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Klaus, Susanne A1 - Ost, Mario T1 - Mitochondrial uncoupling and longevity BT - a role for mitokines? JF - Experimental gerontology N2 - Aging has been viewed both as a random process due to accumulation of molecular and cellular damage over time and as a programmed process linked to cellular pathway important for growth and maturation. These views converge on mitochondria as both the major producer of damaging reactive oxidant species (ROS) and as signaling organelles. A finite proton leak across the inner mitochondrial membrane leading to a slight uncoupling of oxidative phosphorylation and respiration is an intrinsic property of all mitochondria and according to the "uncoupling to survive" hypothesis it has evolved to protect against ROS production to minimize oxidative damage. This hypothesis is supported by evidence linking an increased endogenous, uncoupling protein (UCP1) mediated, as well as experimentally induced mitochondrial uncoupling to an increased lifespan in rodents. This is possibly due to the synergistic activation of molecular pathways linked to life extending effects of caloric restriction as well as a mitohormetic response. Mitohormesis is an adaptive stress response through mitonuclear signaling which increases stress resistance resulting in health promoting effects. Part of this response is the induction of fibroblast growth factor 21 (FGF21) and growth and differentiation factor 15 (GDF15), two stress-induced mitokines which elicit beneficial systemic metabolic effects via endocrine action. KW - Uncoupling proteins KW - Energy metabolism KW - Skeletal muscle KW - Mitohormesis KW - GDF15 KW - FGF21 Y1 - 2019 U6 - https://doi.org/10.1016/j.exger.2019.110796 SN - 0531-5565 SN - 1873-6815 VL - 130 PB - Elsevier Science CY - Amsterdam ER -