TY  - JOUR
A1  - de Vinuesa, Amaya Garcia
A1  - Abdelilah-Seyfried, Salim
A1  - Knaus, Petra
A1  - Zwijsen, An
A1  - Bailly, Sabine
T1  - BMP signaling in vascular biology and dysfunction
JF  - New journal of physics : the open-access journal for physics
N2  - The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology. (C) 2015 Elsevier Ltd. All rights reserved.
KW  - Bone morphogenetic proteins (BMP)
KW  - Signaling
KW  - Vasculature
KW  - Development
KW  - Disease
Y1  - 2016
U6  - https://doi.org/10.1016/j.cytogfr.2015.12.005
SN  - 1359-6101
SN  - 1879-0305
VL  - 27
SP  - 65
EP  - 79
PB  - Elsevier
CY  - Oxford
ER  -