TY - JOUR A1 - Aldrup, Marit T1 - Well let me put it uhm the other way around maybe’ BT - Managing students’ trouble displays in the CLIL classroom JF - Classroom discourse N2 - This study is concerned with repair practices that a teacher and students employ to restore intersubjectivity when faced with interactional problems in a Content and Language Integrated Learning (CLIL) classroom. Adopting a conversation analytic (CA) approach, it examines the interactional treatment of students’ verbal and embodied trouble displays in a video-recorded, teacher-fronted geography lesson held in English at a German high school. At the same time, it explores to what extent the repair practices employed are fitted to this specific interactional context. The analysis shows that students’ verbal trouble displays often result in extensive repair sequences, whereas students’ embodied trouble displays are usually met with teacher self-repair in the transition space. In this way, the latter are resolved much earlier and more quickly. The study further reveals practices like reformulation and translation to be especially useful for repairing interactional problems in classrooms in which a foreign language is used as the medium of instruction. The findings may be of interest for prospective as well as practicing teachers in that they provide relevant insights into how interactional trouble can be successfully managed in (CLIL) classroom interaction. KW - Trouble displays KW - repair KW - embodiment KW - classroom interaction KW - conversation analysis Y1 - 2019 U6 - https://doi.org/10.1080/19463014.2019.1567360 SN - 1946-3014 SN - 1946-3022 VL - 10 IS - 1 SP - 46 EP - 70 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Küttner, Uwe-Alexander T1 - At the intersection of stance-management and repair BT - Meta-pragmatic claims as a practice for disarming disaffiliative responses JF - Gesprächsforschung : Online-Zeitschrift zur verbalen Interaktion N2 - Dieser Beitrag widmet sich der Verwendung eines spezifischen Typs meta-sprachlicher Äußerungen. Er untersucht wie SprecherInnen des Englischen meta-pragmatische Behauptungen, zuvor das „Gleiche" kommuniziert (‚gesagt' oder ‚gemeint') zu haben wie ihr Gesprächspartner, verwenden. Mit Hilfe detaillierter sequenzieller Analysen wird gezeigt, dass diese Behauptungen oft verwendet werden, um disaffiliative Erwiderungen zu entkräften und somit aufkeimende Meinungsverschiedenheiten aufzulösen. Neben der Beschreibung der Mechanismen, die dieser Praktik zu Grunde liegen, werden die verschiedenen verbalen, para- und non-verbalen Ressourcen, die bei der Verwendung dieser Praktik (teils variabel) zum Einsatz ge-bracht werden, inventarisiert. Abschließend wird das Verhältnis dieser Praktik zu anderen Gesprächspraktiken diskutiert. Da sie grundlegend darauf fußt, dass ein Missverständnis auf Seiten des Gegenübers insinuiert wird, kann sie an der Schnittstelle von Praktiken zum Management von Einstellungen bzw. Haltungen und Reparaturen verortet werden. N2 - This article offers an in-depth analysis of one particular type of meta-talk. It looks at how speakers use the meta-pragmatic claim to have previously communicated ('said' or 'meant') the same as, or the equivalent of, what their interlocutor just said. Through detailed sequential analyses, it is shown that this claim is frequently used as a practice for disarming disaffiliative responses and thus to manage (and often resolve) incipient disagreement. Besides unpacking the precise mechanisms underlying this practice, the paper also takes stock of the various (and partly variable) lexico-morpho-syntactic, prosodic and bodily-visual elements of conduct that recurrently enter into its composition. Since the practice essentially rests on the speaker’s insinuation of having been misunderstood by their co-participant, its relationship to the organization of repair will also be discussed. It is argued that the practice operates precisely at the intersection of stance-management (agreement/disagreement) and repair, and that it exhibits features which reflect this intersectional character. Data are in English. KW - meta-talk KW - (dis)affiliation KW - (dis)agreement KW - stance KW - repair KW - Conversation Analysis KW - Metasprache KW - Affiliation/Disaffiliation KW - Meta-Kommunikation KW - Reparaturen KW - Konversationsanalyse Y1 - 2019 UR - http://www.gespraechsforschung-online.de/fileadmin/dateien/heft2019/ga-kuettner.pdf SN - 1617-1837 IS - 20 SP - 115 EP - 156 PB - Verlag für Gesprächsforschung CY - Gleizendorf bei Nürnberg ER - TY - JOUR A1 - Pieper, Imke A1 - Wehe, Christoph A. A1 - Bornhorst, Julia A1 - Ebert, Franziska A1 - Leffers, Larissa A1 - Holtkamp, Michael A1 - Höseler, Pia A1 - Weber, Till A1 - Mangerich, Aswin A1 - Bürkle, Alexander A1 - Karst, Uwe A1 - Schwerdtle, Tanja T1 - Mechanisms of Hg species induced toxicity in cultured human astrocytes BT - genotoxicity and DNA-damage response JF - Metallomics N2 - The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organic Hg species. Mercury species investigated include MeHgCl and thiomersal. Additionally HgCl2 was studied, since in the brain mercuric Hg can be formed by dealkylation of the organic species. As a cellular system astrocytes were used. In vivo astrocytes provide the environment necessary for neuronal function. In the present study, cytotoxic effects of the respective mercuricals increased with rising alkylation level and correlated with their cellular bioavailability. Further experiments revealed for all species at subcytotoxic concentrations no induction of DNA strand breaks, whereas all species massively increased H2O2-induced DNA strand breaks. This co-genotoxic effect is likely due to a disturbance of the cellular DNA damage response. Thus, at nanomolar, sub-cytotoxic concentrations, all three mercury species strongly disturbed poly(ADP-ribosyl)ation, a signalling reaction induced by DNA strand breaks. Interestingly, the molecular mechanism behind this inhibition seems to be different for the species. Since chronic PARP-1 inhibition is also discussed to sacrifice neurogenesis and learning abilities, further experiments on neurons and in vivo studies could be helpful to clarify whether the inhibition of poly(ADP-ribosyl)ation contributes to organic Hg induced neurotoxicity. KW - cell-death KW - poly(ADP-ribose) polymerase-1 KW - neurodegenerative diseases KW - adduct formation KW - thimerosal KW - methylmercury KW - repair KW - neurotoxicity KW - manganese KW - exposure Y1 - 2014 U6 - https://doi.org/10.1039/c3mt00337j SN - 1756-591X SN - 1756-5901 VL - 2014 IS - 6 SP - 662 EP - 671 ER -