TY - JOUR A1 - Knox-Brown, Patrick A1 - Rindfleisch, Tobias A1 - Günther, Anne A1 - Balow, Kim A1 - Bremer, Anne A1 - Walther, Dirk A1 - Miettinen, Markus S. A1 - Hincha, Dirk K. A1 - Thalhammer, Anja T1 - Similar Yet Different BT - Structural and Functional Diversity among Arabidopsis thaliana LEA_4 Proteins JF - International Journal of Molecular Sciences N2 - The importance of intrinsically disordered late embryogenesis abundant (LEA) proteins in the tolerance to abiotic stresses involving cellular dehydration is undisputed. While structural transitions of LEA proteins in response to changes in water availability are commonly observed and several molecular functions have been suggested, a systematic, comprehensive and comparative study of possible underlying sequence-structure-function relationships is still lacking. We performed molecular dynamics (MD) simulations as well as spectroscopic and light scattering experiments to characterize six members of two distinct, lowly homologous clades of LEA_4 family proteins from Arabidopsis thaliana. We compared structural and functional characteristics to elucidate to what degree structure and function are encoded in LEA protein sequences and complemented these findings with physicochemical properties identified in a systematic bioinformatics study of the entire Arabidopsis thaliana LEA_4 family. Our results demonstrate that although the six experimentally characterized LEA_4 proteins have similar structural and functional characteristics, differences concerning their folding propensity and membrane stabilization capacity during a freeze/thaw cycle are obvious. These differences cannot be easily attributed to sequence conservation, simple physicochemical characteristics or the abundance of sequence motifs. Moreover, the folding propensity does not appear to be correlated with membrane stabilization capacity. Therefore, the refinement of LEA_4 structural and functional properties is likely encoded in specific patterns of their physicochemical characteristics. KW - IDP KW - LEA protein KW - abiotic stress KW - dehydration KW - conformational rearrangement KW - membrane stabilization KW - sequence-structure-function relationship Y1 - 2020 U6 - https://doi.org/10.3390/ijms21082794 SN - 1422-0067 VL - 21 IS - 8 PB - Molecular Diversity Preservation International CY - Basel ER - TY - BOOK A1 - Stillmark, Hans-Christian A1 - Limberg, Jörg A1 - Götzmann, Jutta A1 - Vogt, Jochen A1 - Eke, Norbert Otto A1 - Braun, Matthias A1 - Clare, Jennifer A1 - Grimm, Christa A1 - Hofmann, Michael A1 - Bauer, Gerhard A1 - Starke, Frank ED - Stillmark, Hans-Christian T1 - Peter Weiss erinnernd - Ansichten und Einsichten N2 - Der Band versammelt verschiedenen Beiträge, die sich mit dem Leben und Werk von Peter Weiss auseinandersetzen. Die Beiträge wurden auf der Konferenz "Peter Weiss - 100" anläßlich des hundertsten Geburtstages des Autors im Jahre 2016 in Potsdam gehalten. Dabei wirkten unterschiedliche Einrichtungen und Institutionen erstmals gemeinsam im Geburtsort des Künstlers. KW - Peter Weiss KW - Erinnernungskultur KW - Ästhetik des Widerstands KW - Collage KW - engagierte Kunst KW - Auschwitz-Prozess KW - Dokumentartheater Y1 - 2020 SN - 978-3-89693-747-6 PB - Weidler Buchverlag CY - Berlin ET - 150 ER - TY - CHAP A1 - Stillmark, Hans-Christian ED - Stillmark, Hans-Christian T1 - Vorwort T2 - Peter Weiss erinnernd - Ansichten und Einsichten N2 - Der Beitrag leitet die Herausgabe "Peter Weiss erinnerd - Anscihten und Einsichten ein und orientiert die Leser auf den Inhalt des Bandes. KW - Peter Weiss Y1 - 2020 SN - 978-3-89693-747-6 SP - 7 EP - 12 PB - Weidler Buchverlag CY - Berlin ER - TY - JOUR A1 - Schenck, Marcia C. T1 - Small Strangers at the School of Friendship: Memories of Mozambican School Students of The German Democratic Republic JF - German Historical Institute Washington Bulletin / Supplement KW - migration, school of friendship, German Democratic Repubic, Mozambique Y1 - 2020 UR - https://perspectivia.net/servlets/MCRFileNodeServlet/pnet_derivate_00003158/schenk_strangers.pdf IS - 15 SP - 41 EP - 59 PB - Max Weber Stiftung – Deutsche Geisteswissenschaftliche Institute im Ausland ER - TY - JOUR A1 - Agrofylax, Sotirios T1 - Rezension zu: Alexander Schunka: Ein neuer Blick nach Westen. Deutsche Protestanten und Großbritannien (1688‑1740). - Wiesbaden : Harrassowitz, 2019. - ISBN 978-3-447-11260-4 JF - Das achtzehnte Jahrhundert Y1 - 2020 SN - 978-3-8353-3620-9 SN - 0722-740X VL - 44 IS - 1 SP - 145 EP - 146 PB - Wallstein ER - TY - BOOK A1 - Taylor, Charles A1 - Nanz, Patrizia A1 - Taylor, Madeleine Beaubien T1 - Reconstructing democracy BT - how citizens are building from the ground up N2 - Across the world, democracies are suffering from a disconnect between the people and political elites. In communities where jobs and industry are scarce, many feel the government is incapable of understanding their needs or addressing their problems. The resulting frustration has fueled the success of destabilizing demagogues. To reverse this pattern and restore responsible government, we need to reinvigorate democracy at the local level. But what does that mean? Drawing on examples of successful community building in cities large and small, from a shrinking village in rural Austria to a neglected section of San Diego, Reconstructing Democracy makes a powerful case for re-engaging citizens. It highlights innovative grassroots projects and shows how local activists can form alliances and discover their own power to solve problems. Y1 - 2020 SN - 978-0-674-24462-7 PB - Harvard University Press CY - Cambridge ER - TY - BOOK ED - Pschichholz, Christin T1 - The First World War as a Caesura? BT - demographic concepts, population policy, and genocide in the Late Ottoman, Russian, and Habsburg spheres T3 - Gewaltpolitik und Menschenrechte ; 3 N2 - During the phases of mobile warfare, the ethnically and religiously very heterogeneous population in the border regions of the multi-ethnic empires suffered in particular. Even if the real military situation in the course of the war hardly gave cause for concern, the image of disloyal ethnic and national minorities was widespread. This was particularly the case when ethnic groups lived on both sides of the border and social and political tensions had already established themselves along ethnic or religious lines of conflict before the war. Displacements, deportations and mass violence were the result. The genocide of the Armenian population is the most extreme example of this development. This anthology examines the border regions of the Ottoman, Russian and Habsburg empires during the First World War with regard to radical population policy and genocidal violence from a comparative perspective in order to draw a more precise picture of escalating and deescalating factors. Y1 - 2020 SN - 978-3-428-18146-9 SN - 978-3-428-58146-7 PB - Duncker & Humblot CY - Berlin ER - TY - JOUR A1 - Salzwedel, Annett A1 - Heidler, Maria-Dorothea A1 - Meng, Karin A1 - Schikora, Martin A1 - Wegscheider, Karl A1 - Reibis, Rona Katharina A1 - Völler, Heinz T1 - Impact of cognitive performance on disease-related knowledge six months after multi-component rehabilitation in patients after an acute cardiac event JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Background Although associations between cardiovascular diseases and cognitive impairment are well known, the impact of cognitive performance on the success of patient education as a core component of cardiac rehabilitation remains insufficiently investigated so far. Design Prospective observational study in two inpatient cardiac rehabilitation centres between September 2014 and August 2015 with a follow-up six months after cardiac rehabilitation. Method At admission to and discharge from cardiac rehabilitation, the cognitive performance of 401 patients (54.5 ± 6.3 years, 80% men) following an acute coronary syndrome and/or coronary artery bypass graft was tested using the Montreal Cognitive Assessment. Patients’ disease-related knowledge was determined using a quiz (22 items for medical knowledge and 12 items for healthy lifestyle and behaviour) at both times and at follow-up. The change in knowledge after cardiac rehabilitation was analysed in multivariable regression models. Potentially influencing parameters (e.g. level of education, medication, cardiovascular risk factors, coronary artery bypass graft, comorbidities, exercise capacity) were considered. Results During cardiac rehabilitation, disease-related knowledge was significantly enhanced in both scales. At follow-up, the average level of medical knowledge was significantly reduced, while lifestyle knowledge remained at a stable level. The maintenance of knowledge after cardiac rehabilitation was predominantly predicted by prior knowledge, cognitive performance at discharge from cardiac rehabilitation and, in the case of medical knowledge, by coronary artery bypass graft. Conclusion Patient education in cardiac rehabilitation led to enhanced disease-related knowledge, but the maintenance of this essentially depended on patients’ cognitive performance, especially after coronary artery bypass graft. Therefore, patient education concepts in cardiac rehabilitation should be reconsidered and adjusted as needed. KW - Mild cognitive impairment KW - cardiac rehabilitation KW - patient education KW - coronary artery disease KW - secondary prevention Y1 - 2020 U6 - https://doi.org/10.1177/2047487318791609 SN - 2047-4873 SN - 2047-4881 VL - 26 IS - 1 SP - 46 EP - 55 PB - Sage Publ. CY - London ER - TY - THES A1 - Jing, Yue T1 - Characterization of Serine Carboxypeptidase-like (SCPL) gene family in Brassicaceae Y1 - 2020 ER - TY - JOUR A1 - Ryo, Masahiro A1 - Jeschke, Jonathan M. A1 - Rillig, Matthias C. A1 - Heger, Tina T1 - Machine learning with the hierarchy-of-hypotheses (HoH) approach discovers novel pattern in studies on biological invasions JF - Research synthesis methods N2 - Research synthesis on simple yet general hypotheses and ideas is challenging in scientific disciplines studying highly context-dependent systems such as medical, social, and biological sciences. This study shows that machine learning, equation-free statistical modeling of artificial intelligence, is a promising synthesis tool for discovering novel patterns and the source of controversy in a general hypothesis. We apply a decision tree algorithm, assuming that evidence from various contexts can be adequately integrated in a hierarchically nested structure. As a case study, we analyzed 163 articles that studied a prominent hypothesis in invasion biology, the enemy release hypothesis. We explored if any of the nine attributes that classify each study can differentiate conclusions as classification problem. Results corroborated that machine learning can be useful for research synthesis, as the algorithm could detect patterns that had been already focused in previous narrative reviews. Compared with the previous synthesis study that assessed the same evidence collection based on experts' judgement, the algorithm has newly proposed that the studies focusing on Asian regions mostly supported the hypothesis, suggesting that more detailed investigations in these regions can enhance our understanding of the hypothesis. We suggest that machine learning algorithms can be a promising synthesis tool especially where studies (a) reformulate a general hypothesis from different perspectives, (b) use different methods or variables, or (c) report insufficient information for conducting meta-analyses. KW - artificial intelligence KW - hierarchy-of-hypotheses approach KW - machine learning KW - meta-analysis KW - synthesis KW - systematic review Y1 - 2019 U6 - https://doi.org/10.1002/jrsm.1363 SN - 1759-2879 SN - 1759-2887 VL - 11 IS - 1 SP - 66 EP - 73 PB - Wiley CY - Hoboken ER -