TY - JOUR
A1 - Kiefer, Thomas
A1 - Krahl, Dorothea
A1 - Hirt, Carsten
A1 - Völler, Heinz
A1 - Voelkel, Lorenz
A1 - Daeschlein, Georg
T1 - Influence of treatment caused impairments on anxiety and depression in patients with cancer of the Esophagus or the Esophagogastric junction
JF - Journal of gastrointestinal cancer
N2 - Purpose
After therapy of cancer of the esophagus or the esophagogastric junction, patients often suffer from anxiety and depression. Some risk factors for elevated anxiety and depression are reported, but the influence of steatorrhea, the frequency of which has only recently been reported, has not yet been investigated.
Method
Using the Hospital Anxiety and Depression Scale (HADS), we analyzed the correlation of anxiety and depression with steatorrhea, appetite, and weight loss in 72 patients with cancer of the esophagus or of the esophagogastric junction, who were treated at our rehabilitation clinic between January 2011 and December 2014. In addition, effectiveness of psychological interviews was analyzed.
Results
We have evaluable anxiety questionnaires from 51 patients showing a median anxiety value of 5 (range 0-13). As for the depression, results from evaluable questionnaires of 54 patients also showed a median value of 5 (range 0-15). Increased anxiety and depression values (> 7) were observed in 25.4% and 37.0% of the patients respectively. Patients who were admitted with steatorrhea for rehabilitation showed a statistically higher anxiety value (median 6.3 vs. 4.7, p < 0.05), reduced appetite, and a weight loss above 15 kg depicting a correlation to anxiety and depression. Psychological conversations helped lowering the depression but had no influence on anxiety.
Conclusions
Impairments after cancer treatment, such as steatorrhea, appetite loss, and weight loss, should be interpreted as an alarm signal and should necessitate screening for increased anxiety and depression. Psychological therapy can help improving the extent of the depression.
KW - Anxiety
KW - Depression
KW - Esophagus carcinoma
KW - Exocrine pancreas
KW - insufficiency
KW - Rehabilitation
KW - Steatorrhea
Y1 - 2019
U6 - https://doi.org/10.1007/s12029-018-00193-7
SN - 1941-6628
SN - 1941-6636
VL - 51
IS - 1
SP - 30
EP - 34
PB - Springer
CY - New York
ER -
TY - JOUR
A1 - Heissel, Andreas
A1 - Pietrek, Anou F.
A1 - Rapp, Michael Armin
A1 - Heinzel, Stephan
A1 - Williams, Geoffrey
T1 - Perceived health care climate of older people attending an exercise program
BT - validation of the german short version of the health care climate questionnaire
JF - Journal of aging and physical activity : JAPA ; the official journal of the International Society for Aging and Physical Activity
N2 - The role of perceived need support from exercise professionals in improving mental health was examined in a sample of older adults, thereby validating the short Health Care Climate Questionnaire. A total of 491 older people (M = 72.68 years; SD = 5.47) attending a health exercise program participated in this study. Cronbach's alpha was found to be high (alpha = .90). Satisfaction with the exercise professional correlated moderately with the short Health Care Climate Questionnaire mean value (r = .38; p < .01). The mediator analyses yielded support for the self-determination theory process model in older adults by showing both basic need satisfaction and frustration as mediating variables between perceived autonomy support and depressive symptoms. The short Health Care Climate Questionnaire is an economical instrument for assessing basic need satisfaction provided by the exercise therapist from the participant's perspective. Furthermore, this cross-sectional study supported the link from coaching style to the satisfaction/frustration of basic psychological needs, which in turn, predicted mental health. Analyses of criterion validity suggest a revision of the construct by integrating need frustration.
KW - autonomy support
KW - basic psychological need satisfaction and frustration
KW - depression
KW - need support
KW - physical activity
Y1 - 2019
U6 - https://doi.org/10.1123/japa.2018-0350
SN - 1063-8652
SN - 1543-267X
VL - 28
IS - 2
SP - 276
EP - 286
PB - Human Kinetics Publ.
CY - Champaign
ER -
TY - GEN
A1 - Garbusow, Maria
A1 - Nebe, Stephan
A1 - Sommer, Christian
A1 - Kuitunen-Paul, Sören
A1 - Sebold, Miriam Hannah
A1 - Schad, Daniel
A1 - Friedel, Eva
A1 - Veer, Ilya M.
A1 - Wittchen, Hans-Ulrich
A1 - Rapp, Michael Armin
A1 - Ripke, Stephan
A1 - Walter, Henrik
A1 - Huys, Quentin J. M.
A1 - Schlagenhauf, Florian
A1 - Smolka, Michael N.
A1 - Heinz, Andreas
T1 - Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers
BT - Behavioral, Neural and Polygenic Correlates
T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 841
KW - Pavlovian-to-instrumental transfer
KW - amygdala
KW - alcohol
KW - polygenic risk
KW - high risk drinkers
Y1 - 2019
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473280
SN - 1866-8364
IS - 841
ER -
TY - JOUR
A1 - Lorenz, Robert C.
A1 - Matthias, Katja
A1 - Pieper, Dawid
A1 - Wegewitz, Uta
A1 - Morche, Johannes
A1 - Nocon, Marc
A1 - Rissling, Olesja
A1 - Schirm, Jacqueline
A1 - Freitag, Simone
A1 - Jacobs, Anja
T1 - AMSTAR 2 overall confidence rating
BT - lacking discriminating capacity or requirement of high methodological quality?
JF - Journal of clinical epidemiology : including pharmacoepidemiology reports
Y1 - 2019
U6 - https://doi.org/10.1016/j.jclinepi.2019.10.006
SN - 0895-4356
SN - 1878-5921
VL - 119
SP - 142
EP - 144
PB - Elsevier
CY - New York
ER -
TY - JOUR
A1 - Quarmby, Andrew James
A1 - Khajooei, Mina
A1 - Engel, Tilman
A1 - Kaplick, Hannes
A1 - Mayer, Frank
T1 - The feasibility of a split-belt instrumented treadmill running protocol with perturbations
JF - Journal of biomechanics
N2 - Unexpected perturbations during locomotion can occur during daily life or sports performance. Adequate compensation for such perturbations is crucial in maintaining effective postural control. Studies utilising instrumented treadmills have previously validated perturbed walking protocols, however responses to perturbed running protocols remain less investigated. Therefore, the purpose of this study was to investigate the feasibility of a new instrumented treadmill-perturbed running protocol.
Fifteen participants (age = 2 8 +/- 3 years; height = 172 +/- 9 cm; weight = 69 +/- 10 kg; 60% female) completed an 8-minute running protocol at baseline velocity of 2.5 m/s (9 km/h), whilst 15 one-sided belt perturbations were applied (pre-set perturbation characteristics: 150 ms delay (post-heel contact); 2.0 m/s amplitude; 100 ms duration). Perturbation characteristics and EMG responses were recorded. Bland-Altman analysis (BLA) was employed (bias +/- limits of agreement (LOA; bias +/- 1.96*SD)) and intra-individual variability of repeated perturbations was assessed via Coefficients of Variation (CV) (mean +/- SD).
On average, 9.4 +/- 2.2 of 15 intended perturbations were successful. Perturbation delay was 143 +/- 10 ms, amplitude was 1.7 +/- 0.2 m/s and duration was 69 +/- 10 ms. BLA showed -7 +/- 13 ms for delay, -0.3 +/- 0.1 m/s for amplitude and -30 +/- 10 ms for duration. CV showed variability of 19 +/- 4.5% for delay, 58 +/- 12% for amplitude and 30 +/- 7% for duration. EMG RMS amplitudes of the legs and trunk ranged from 113 +/- 25% to 332 +/- 305% when compared to unperturbed gait. This study showed that the application of sudden perturbations during running can be achieved, though with increased variability across individuals. The perturbations with the above characteristics appear to have elicited a neuromuscular response during running.
KW - Lower-extremity perturbations
KW - Split-belt treadmill
KW - Running
KW - Stumbling
KW - EMC
Y1 - 2020
U6 - https://doi.org/10.1016/j.jbiomech.2019.109493
SN - 0021-9290
SN - 1873-2380
VL - 98
PB - Elsevier
CY - Oxford
ER -
TY - THES
A1 - Chaabene, Helmi
T1 - Effects of resistance training on measures of physical fitness in young athletes
Y1 - 2019
ER -
TY - THES
A1 - Dech, Silas
T1 - Therapeutisches Klettern nach dem Potsdamer Modell bei Jugendlichen mit Skoliose
T1 - Therapeutic climbing according to the Potsdam Model in adolescents with scoliosis
BT - ein Trainingskonzept mit Übungskatalog und Vorbereitung einer randomisierten kontrollierten Studie
BT - a training concept with an exercise booklet and preparation of a randomized controlled trial
N2 - Bisher ist die Ursache für die Entstehung der meisten Skoliosen noch ungeklärt und damit eine kausale Behandlung der Betroffenen unmöglich. Die vorliegende Arbeit geht davon aus, dass der Auslöser für die sogenannte idiopathische Skoliose eine funktionelle Störung von Muskeln ist, die sich in einer verminderten relativen Haltekraft äußert. Durch gezielte willkürliche Muskelanspannungen könnte es möglich sein, kompensatorisch auf die Deformität einzuwirken, um damit ein Fortschreiten zu verhindern bzw. sogar eine Regression hervorzurufen. Insbesondere Patientengruppen mit einem hohen Progressionsrisiko, wie Jugendliche im Wachstumsalter, könnten davon profitieren.
Ein Muskeltraining kann mit unterschiedlichsten Hilfsmitteln und Methoden erfolgen. Eine Möglichkeit bietet auch das Klettern. Im Kern wird daher ein Trainingskonzept zum Therapeutischen Klettern bei Jugendlichen mit Skoliose vorgestellt. Dabei beruft sich der Autor auf das Potsdamer Modell. Dieses Modell erlaubt es, gezielte Kraftübungen systematisiert an der Kletterwand in Absprunghöhe umzusetzen. Materielle Sicherungsmaßnahmen sind dadurch nicht erforderlich und eventuell notwendige Korrekturen bzw. Hilfestellungen können direkt erfolgen. Hauptinhalt eines Trainings nach dem vorgestellten Konzept sind spielerische Bewegungserfahrung innerhalb der Sportart Klettern und ein Systembouldertraining.
In einem beigefügten Übungskatalog werden für letzteres Möglichkeiten der praktischen Umsetzun-gen gegeben. Die Übungen fokussieren sich auf die Aktivierung und das Training wirbelkörperdero-tierender Muskeln. Im Hauptteil einer Trainingseinheit können sie dann in Kombination mit der Kor-rektur der Seitverbiegung und des sagittalen Profils (3D Autokorrektur) unter Aufsicht eines geschul-ten Therapeuten durchgeführt werden. Die Arbeit erhebt den Anspruch, einem Leser vom Fach, die Auswahl der Übungen und die darin enthaltene individuelle Anpassung an den Patienten aus funktionell-anatomischer Sicht zu begründen.
In naher Zukunft wird das Konzept in einer randomisiert kontrollierten Studie untersucht. Alle notwendigen Vorbereitungen wurden im Rahmen dieser Arbeit getroffen.
N2 - To date, the cause of most scolioses is still unclear and, therefore, causal treatment is impossible. The present work assumes that the trigger for a so-called idiopathic scoliosis is a functional disorder of muscles expressed by a reduced relative holding force. Special voluntary muscle actions might have a compensatory effect on the deformity and preventing a progression or even inducing a regression. In particular, patients with a high risk of progression, such as adolescents, could benefit from these.
There are many different muscle training regimes. Climbing also offers a possibility. Thus, a training concept for therapeutic climbing in adolescents with scoliosis is presented. The author refers to the Potsdam Model, thereby. This model makes it possible to systematically implement special strength exercises on the climbing wall at jumping height. Climbing protections are not necessary and any therapeutic corrections or assistance can be given directly. The main contents of the concept are playful experiences of climbing movements and a systematical boulder training.
For the latter, exercises are given in an enclosed booklet. The exercises focus on the activation and training of muscles which derotate the spinal column. In the main part of a training session, they can be performed in combination with a correction of lateral bending and sagittal profile (3D autocorrection) by supervision of a trained therapist. The work claims to explain the selection of the exercises and the individual adaptation to the patient from a functional-anatomical point of view to health professionals.
In the near future, the concept will be investigated in a randomized controlled trial. All necessary preparations have been made in the context of this work.
KW - Klettertherapie
KW - Sporttherapie
KW - adoleszente idiopathische Skoliose
KW - skoliosespezifische Übungen
KW - Bouldern
KW - climbing therapy
KW - exercise therapy
KW - adolescent idiopathic scoliosis
KW - scoliosis-specific exercises
KW - bouldering
Y1 - 2021
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532072
ER -
TY - JOUR
A1 - Böttinger, Erwin
T1 - Wendepunkt für Gesundheit
JF - Die Zukunft der Medizin : Disruptive Innovationen revolutionieren Medizin und Gesundheit
Y1 - 2019
SN - 978-3-95466-398-9
SN - 978-3-95466-448-1
SP - 201
EP - 210
PB - Medizinisch Wissenschaftliche Verlagsgesellschaft
CY - Berlin
ER -
TY - BOOK
ED - Böttinger, Erwin
ED - zu Putlitz, Jasper
T1 - Die Zukunft der Medizin
BT - disruptive Innovationen revolutionieren Medizin und Gesundheit
N2 - Die Medizin im 21. Jahrhundert wird sich so schnell verändern wie nie zuvor – und mit ihr das Gesundheitswesen. Bahnbrechende Entwicklungen in Forschung und Digitalisierung werden die Auswertung und Nutzung riesiger Datenmengen in kurzer Zeit ermöglichen. Das wird unsere Kenntnisse über Gesundheit und gesund sein, sowie über die Entstehung, Prävention und Heilung von Krankheiten vollkommen verändern. Gleichzeitig wird sich die Art und Weise, wie Medizin praktiziert wird, fundamental verändern. Das Selbstverständnis nahezu aller Akteure wird sich rasch weiterentwickeln müssen. Das Gesundheitssystem wird in allen Bereichen umgebaut und teilweise neu erfunden werden. Digitale Transformation, Personalisierung und Prävention sind die Treiber der neuen Medizin.
Deutschland darf den Anschluss nicht verpassen. Im Vergleich mit anderen Ländern ist das deutsche Gesundheitswesen in vielen Punkten bedrohlich rückständig und fragmentiert. Um die Medizin und das Gesundheitswesen in Deutschland langfristig zukunftsfest zu machen, bedarf es vieler Anstrengungen – vor allem aber Offenheit gegenüber Veränderungen, sowie einen regulatorischen Rahmen, der ermöglicht, dass die medizinischen und digitalen Innovationen beim Patienten ankommen.
DIE ZUKUNFT DER MEDIZIN beschreibt Entwicklungen und Technologien, die die Medizin und das Gesundheitswesen im 21. Jahrhundert prägen werden. Das Buch informiert über die zum Teil dramatischen, disruptiven Innovationen in der Forschung, die durch Big Data, Künstliche Intelligenz und Robotik möglich werden.
Die Autoren sind führende Vordenker ihres Fachs und beschreiben aus langjähriger Erfahrung im In- und Ausland zukünftige Entwicklungen, die jetzt bereits greifbar sind.
Y1 - 2019
SN - 978-3-95466-398-9
SN - 978-3-95466-448-1
PB - Medizinisch Wissenschaftliche Verlagsgesellschaft
CY - Berlin
ER -
TY - JOUR
A1 - Tschorn, Mira
A1 - Rieckmann, Nina
A1 - Arolt, Volker
A1 - Beer, Katja
A1 - Haverkamp, Wilhelm
A1 - Martus, Peter
A1 - Waltenberger, Johannes
A1 - Müller-Nordhorn, Jacqueline
A1 - Ströhle, Andreas
T1 - Erkennungsgüte dreier deutschsprachiger Screeninginstrumente für Depression bei hospitalisierten Patienten mit koronarer Herzerkrankung
T1 - Diagnostic Accuracy of German Depression Screenings in Patients with Coronary Heart Disease
JF - Psychiatrische Praxis
N2 - Ziel Vergleich der Erkennungsgüte von drei Depressions-Screeninginstrumenten bei Patienten mit koronarer Herzerkrankung (KHK).
Methodik 1019 KHK-Patienten erhielten den Patient Health Questionnaire (PHQ-9 und PHQ-2) und die Hospital Anxiety and Depression Scale (HADS-D) sowie ein klinisches Interview (Composite International Diagnostic Interview) als Referenzstandard.
Ergebnisse Bezüglich der Erkennungsgüte waren PHQ-9 und HADS-D dem PHQ-2 überlegen. Optimale Cut-off-Werte waren 7 (PHQ-9 und HADS-D) und 2 (PHQ-2).
Schlussfolgerung PHQ-9 und HADS-D haben eine vergleichbare Diskriminationsfähigkeit für depressive Störungen bei KHK-Patienten.
N2 - Objective To compare the diagnostic accuracy of German depression screening instruments in patients with coronary heart disease (CHD). Methods 1019 CHD patients completed the Patient Health Questionnaire (PHQ-9 and PHQ-2) and the Hospital Anxiety and Depression Scale (HADS-D). The Composite International Diagnostic Interview served as reference standard for "any depressive disorder" and "major depression". Results The accuracy of the PHQ-9 and the HADS-D was comparable according to the area under the curve, and both were superior to the PHQ-2. The optimal cut-off according to the Youden index (maximum sum of sensitivity and specificity) was 7 for both instruments. At this optimal cut-off, the PHQ-9 had a higher sensitivity compared to the HADS-D, but a lower specificity (below 68). Results remained similar when patients who reported that they currently underwent treatment for depression were excluded. Conclusion The PHQ-9 and the HADS-D have comparable overall diagnostic accuracy in CHD patients. In line with previous screening studies with CHD patients, the optimal cut-offs were below the cut-offs that are recommended in the literature.
KW - coronary artery disease
KW - depression
KW - diagnosis
KW - screening
KW - validity
Y1 - 2019
U6 - https://doi.org/10.1055/s-0042-123434
SN - 0303-4259
SN - 1439-0876
VL - 46
IS - 1
SP - 41
EP - 48
PB - Thieme
CY - Stuttgart
ER -