TY  - JOUR
A1  - Cestnik, Rok
A1  - Rosenblum, Michael
T1  - Inferring the phase response curve from observation of a continuously perturbed oscillator
JF  - Scientific Reports
N2  - Phase response curves are important for analysis and modeling of oscillatory dynamics in various applications, particularly in neuroscience. Standard experimental technique for determining them requires isolation of the system and application of a specifically designed input. However, isolation is not always feasible and we are compelled to observe the system in its natural environment under free-running conditions. To that end we propose an approach relying only on passive observations of the system and its input. We illustrate it with simulation results of an oscillator driven by a stochastic force.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-32069-y
SN  - 2045-2322
VL  - 8
SP  - 1
EP  - 10
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Topçu, Çağdaş
A1  - Frühwirth, Matthias
A1  - Moser, Maximilian
A1  - Rosenblum, Michael
A1  - Pikovskij, Arkadij
T1  - Disentangling respiratory sinus arrhythmia in heart rate variability records
JF  - Physiological Measurement
N2  - Objective: Several different measures of heart rate variability, and particularly of respiratory sinus arrhythmia, are widely used in research and clinical applications. For many purposes it is important to know which features of heart rate variability are directly related to respiration and which are caused by other aspects of cardiac dynamics. Approach: Inspired by ideas from the theory of coupled oscillators, we use simultaneous measurements of respiratory and cardiac activity to perform a nonlinear disentanglement of the heart rate variability into the respiratory-related component and the rest. Main results: The theoretical consideration is illustrated by the analysis of 25 data sets from healthy subjects. In all cases we show how the disentanglement is manifested in the different measures of heart rate variability. Significance: The suggested technique can be exploited as a universal preprocessing tool, both for the analysis of respiratory influence on the heart rate and in cases when effects of other factors on the heart rate variability are in focus.
KW  - respiratory sinus arrhythmia
KW  - heart rate variability
KW  - coupled oscillators model
KW  - phase dynamics
KW  - data analysis
Y1  - 2018
U6  - https://doi.org/10.1088/1361-6579/aabea4
SN  - 0967-3334
SN  - 1361-6579
VL  - 39
IS  - 5
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  -