TY  - JOUR
A1  - Zheng, Ju-Sheng
A1  - Luan, Jian'an
A1  - Sofianopoulou, Eleni
A1  - Imamura, Fumiaki
A1  - Stewart, Isobel D.
A1  - Day, Felix R.
A1  - Pietzner, Maik
A1  - Wheeler, Eleanor
A1  - Lotta, Luca A.
A1  - Gundersen, Thomas E.
A1  - Amiano, Pilar
A1  - Ardanaz, Eva
A1  - Chirlaque, Maria-Dolores
A1  - Fagherazzi, Guy
A1  - Franks, Paul W.
A1  - Kaaks, Rudolf
A1  - Laouali, Nasser
A1  - Mancini, Francesca Romana
A1  - Nilsson, Peter M.
A1  - Onland-Moret, N. Charlotte
A1  - Olsen, Anja
A1  - Overvad, Kim
A1  - Panico, Salvatore
A1  - Palli, Domenico
A1  - Ricceri, Fulvio
A1  - Rolandsson, Olov
A1  - Spijkerman, Annemieke M. W.
A1  - Sanchez, Maria-Jose
A1  - Schulze, Matthias Bernd
A1  - Sala, Nuria
A1  - Sieri, Sabina
A1  - Tjonneland, Anne
A1  - Tumino, Rosario
A1  - van der Schouw, Yvonne T.
A1  - Weiderpass, Elisabete
A1  - Riboli, Elio
A1  - Danesh, John
A1  - Butterworth, Adam S.
A1  - Sharp, Stephen J.
A1  - Langenberg, Claudia
A1  - Forouhi, Nita G.
A1  - Wareham, Nicholas J.
T1  - Plasma vitamin C and type 2 diabetes
BT  - genome-wide association study and Mendelian randomization analysis in European populations
JF  - Diabetes care
N2  - OBJECTIVE: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.

RESEARCH DESIGN AND METHODS: We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. 

RESULTS: We identified 11 genomic regions associated with plasma vitamin C (P < 5 x 10(-8)), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10).

CONCLUSIONS: These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.
Y1  - 2020
U6  - https://doi.org/10.2337/dc20-1328
SN  - 0149-5992
SN  - 1935-5548
VL  - 44
IS  - 1
SP  - 98
EP  - 106
PB  - American Diabetes Association
CY  - Alexandria
ER  - 
TY  - GEN
A1  - Saberi Hosnijeh, Fatemeh
A1  - Casabonne, Delphine
A1  - Nieters, Alexandra
A1  - Solans, Marta
A1  - Naudin, Sabine
A1  - Ferrari, Pietro
A1  - Mckay, James D.
A1  - Benavente, Yolanda
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Severi, Gianluca
A1  - Boutron Ruault, Marie-Christine
A1  - Besson, Caroline
A1  - Agnoli, Claudia
A1  - Masala, Giovanna
A1  - Sacerdote, Carlotta
A1  - Tumino, Rosario
A1  - Huerta, Jose Maria
A1  - Amiano, Pilar
A1  - Rodriguez-Barranco, Miguel
A1  - Bonet, Catalina
A1  - Barricarte, Aurelio
A1  - Christakoudi, Sofia
A1  - Knuppel, Anika
A1  - Bueno-de-Mesquita, Bas
A1  - Schulze, Matthias Bernd
A1  - Kaaks, Rudolf
A1  - Canzian, Federico
A1  - Spath, Florentin
A1  - Jerkeman, Mats
A1  - Rylander, Charlotta
A1  - Tjonneland, Anne
A1  - Olsen, Anja
A1  - Borch, Kristin Benjaminsen
A1  - Vermeulen, Roel
T1  - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma
BT  - an exposome-wide analysis
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1374 
KW  - exposome
KW  - exposome‐ wide association study
KW  - lifestyle
KW  - lymphoma
KW  - prospective study
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-573562
SN  - 1866-8372
IS  - 9
ER  - 
TY  - JOUR
A1  - Saberi Hosnijeh, Fatemeh
A1  - Casabonne, Delphine
A1  - Nieters, Alexandra
A1  - Solans, Marta
A1  - Naudin, Sabine
A1  - Ferrari, Pietro
A1  - Mckay, James D.
A1  - Benavente, Yolanda
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Severi, Gianluca
A1  - Boutron Ruault, Marie-Christine
A1  - Besson, Caroline
A1  - Agnoli, Claudia
A1  - Masala, Giovanna
A1  - Sacerdote, Carlotta
A1  - Tumino, Rosario
A1  - Huerta, Jose Maria
A1  - Amiano, Pilar
A1  - Rodriguez-Barranco, Miguel
A1  - Bonet, Catalina
A1  - Barricarte, Aurelio
A1  - Christakoudi, Sofia
A1  - Knuppel, Anika
A1  - Bueno-de-Mesquita, Bas
A1  - Schulze, Matthias Bernd
A1  - Kaaks, Rudolf
A1  - Canzian, Federico
A1  - Spath, Florentin
A1  - Jerkeman, Mats
A1  - Rylander, Charlotta
A1  - Tjonneland, Anne
A1  - Olsen, Anja
A1  - Borch, Kristin Benjaminsen
A1  - Vermeulen, Roel
T1  - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma
BT  - an exposome-wide analysis
JF  - International journal of cancer
N2  - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
KW  - exposome
KW  - exposome‐ wide association study
KW  - lifestyle
KW  - lymphoma
KW  - prospective study
Y1  - 2020
U6  - https://doi.org/10.1002/ijc.33369
SN  - 0020-7136
SN  - 1097-0215
VL  - 148
IS  - 9
SP  - 2115
EP  - 2128
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Kroeger, Janine
A1  - Meidtner, Karina
A1  - Stefan, Norbert
A1  - Guevara, Marcela
A1  - Kerrison, Nicola D.
A1  - Ardanaz, Eva
A1  - Aune, Dagfinn
A1  - Boeing, Heiner
A1  - Dorronsoro, Miren
A1  - Dow, Courtney
A1  - Fagherazzi, Guy
A1  - Franks, Paul W.
A1  - Freisling, Heinz
A1  - Gunter, Marc J.
A1  - Maria Huerta, Jose
A1  - Kaaks, Rudolf
A1  - Key, Timothy J.
A1  - Khaw, Kay Tee
A1  - Krogh, Vittorio
A1  - Kuehn, Tilman
A1  - Mancini, Francesca Romana
A1  - Mattiello, Amalia
A1  - Nilsson, Peter M.
A1  - Olsen, Anja
A1  - Overvad, Kim
A1  - Palli, Domenico
A1  - Ramon Quiros, J.
A1  - Rolandsson, Olov
A1  - Sacerdote, Carlotta
A1  - Sala, Nuria
A1  - Salamanca-Fernandez, Elena
A1  - Sluijs, Ivonne
A1  - Spijkerman, Annemieke M. W.
A1  - Tjonneland, Anne
A1  - Tsilidis, Konstantinos K.
A1  - Tumino, Rosario
A1  - van der Schouw, Yvonne T.
A1  - Forouhi, Nita G.
A1  - Sharp, Stephen J.
A1  - Langenberg, Claudia
A1  - Riboli, Elio
A1  - Schulze, Matthias Bernd
A1  - Wareham, Nicholas J.
T1  - Circulating Fetuin-A and Risk of Type 2 Diabetes
BT  - a mendelian randomization analysis
JF  - Diabetes : a journal of the American Diabetes Association
N2  - Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. Weaimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 mu g/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population.
Y1  - 2018
U6  - https://doi.org/10.2337/db17-1268
SN  - 0012-1797
SN  - 1939-327X
VL  - 67
IS  - 6
SP  - 1200
EP  - 1205
PB  - American Diabetes Association
CY  - Alexandria
ER  - 
TY  - JOUR
A1  - Jannasch, Franziska
A1  - Kröger, Janine
A1  - Agnoli, Claudia
A1  - Barricarte, Aurelio
A1  - Boeing, Heiner
A1  - Cayssials, Valérie
A1  - Colorado-Yohar, Sandra
A1  - Dahm, Christina C.
A1  - Dow, Courtney
A1  - Fagherazzi, Guy
A1  - Franks, Paul W.
A1  - Freisling, Heinz
A1  - Gunter, Marc J.
A1  - Kerrison, Nicola D.
A1  - Key, Timothy J.
A1  - Khaw, Kay-Tee
A1  - Kühn, Tilman
A1  - Kyro, Cecilie
A1  - Mancini, Francesca Romana
A1  - Mokoroa, Olatz
A1  - Nilsson, Peter
A1  - Overvad, Kim
A1  - Palli, Domenico
A1  - Panico, Salvatore
A1  - Quiros Garcia, Jose Ramon
A1  - Rolandsson, Olov
A1  - Sacerdote, Carlotta
A1  - Sanchez, Maria-Jose
A1  - Sahrai, Mohammad Sediq
A1  - Schübel, Ruth
A1  - Sluijs, Ivonne
A1  - Spijkerman, Annemieke M. W.
A1  - Tjonneland, Anne
A1  - Tong, Tammy Y. N.
A1  - Tumino, Rosario
A1  - Riboli, Elio
A1  - Langenberg, Claudia
A1  - Sharp, Stephen J.
A1  - Forouhi, Nita G.
A1  - Schulze, Matthias Bernd
A1  - Wareham, Nicholas J.
T1  - Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations
JF  - The Journal of Nutrition
N2  - Background: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence. 
Objective: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries.
Methods: Dietary intake data were used, assessed by country-specific questionnaires at baseline of 11,183 incident diabetes cases and 14,694 subcohort members (mean age 52.9 y) from 8 countries, nested within the European Prospective Investigation into Cancer and Nutrition study (mean follow-up time 6.9 y). Exploratory dietary patterns were derived by principal component analysis. HRs for incident type 2 diabetes were calculated by Prentice-weighted Cox proportional hazard regression models. Diabetes-associated dietary patterns were simplified or replicated to be applicable in other countries. A meta-analysis across all countries evaluated the generalizability of the diabetes-association.
Results: Two dietary patterns per country/UK-center, of which overall 3 dietary patterns were diabetes-associated, were identified. A risk-lowering French dietary pattern was not confirmed across other countries: pooled HRFrance per 1 SD: 1.00; 95% CI: 0.90, 1.10. Risk-increasing dietary patterns, derived in Spain and UK-Norfolk, were confirmed, but only the latter statistically significantly: HRSpain: 1.09; 95% CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; 95% CI: 1.04, 1.20. Respectively, this dietary pattern was characterized by relatively high intakes of potatoes, processed meat, vegetable oils, sugar, cake and cookies, and tea. Conclusions: Only few country/center-specific dietary patterns (3 of 18) were statistically significantly associated with diabetes incidence in this multicountry European study population. One pattern, whose association with diabetes was confirmed across other countries, showed overlaps in the food groups potatoes and processed meat with identified diabetes-associated dietary patterns from other studies. The study demonstrates that replication of associations of exploratory patterns with health outcomes is feasible and a necessary step to overcome population-specificity in associations from such analyses.
KW  - dietary patterns
KW  - principal component analysis
KW  - diet-disease association
KW  - type 2 diabetes mellitus
KW  - replication
KW  - meta-analysis
Y1  - 2019
U6  - https://doi.org/10.1093/jn/nxz031
SN  - 0022-3166
SN  - 1541-6100
VL  - 149
IS  - 6
SP  - 1047
EP  - 1055
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Christakoudi, Sofia
A1  - Pagoni, Panagiota
A1  - Ferrari, Pietro
A1  - Cross, Amanda J.
A1  - Tzoulaki, Ioanna
A1  - Muller, David C.
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Murphy, Neil
A1  - Dossus, Laure
A1  - Turzanski Fortner, Renee
A1  - Agudo, Antonio
A1  - Overvad, Kim
A1  - Perez-Cornago, Aurora
A1  - Key, Timothy J.
A1  - Brennan, Paul
A1  - Johansson, Mattias
A1  - Tjonneland, Anne
A1  - Halkjaer, Jytte
A1  - Boutron-Ruault, Marie-Christine
A1  - Artaud, Fanny
A1  - Severi, Gianluca
A1  - Kaaks, Rudolf
A1  - Schulze, Matthias Bernd
A1  - Bergmann, Manuela M.
A1  - Masala, Giovanna
A1  - Grioni, Sara
A1  - Simeon, Vittorio
A1  - Tumino, Rosario
A1  - Sacerdote, Carlotta
A1  - Skeie, Guri
A1  - Rylander, Charlotta
A1  - Borch, Kristin Benjaminsen
A1  - Quiros, J. Ramon
A1  - Rodriguez-Barranco, Miguel
A1  - Chirlaque, Maria-Dolores
A1  - Ardanaz, Eva
A1  - Amiano, Pilar
A1  - Drake, Isabel
A1  - Stocks, Tanja
A1  - Häggström, Christel
A1  - Harlid, Sophia
A1  - Ellingjord-Dale, Merete
A1  - Riboli, Elio
A1  - Tsilidis, Konstantinos K.
T1  - Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
JF  - International journal of cancer
N2  - Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
KW  - BMI change
KW  - cancer
KW  - middle adulthood
KW  - weight gain
KW  - weight loss
Y1  - 2020
U6  - https://doi.org/10.1002/ijc.33339
SN  - 0020-7136
SN  - 1097-0215
VL  - 148
IS  - 7
SP  - 1637
EP  - 1651
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Christakoudi, Sofia
A1  - Pagoni, Panagiota
A1  - Ferrari, Pietro
A1  - Cross, Amanda J.
A1  - Tzoulaki, Ioanna
A1  - Muller, David C.
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Murphy, Neil
A1  - Dossus, Laure
A1  - Turzanski Fortner, Renee
A1  - Agudo, Antonio
A1  - Overvad, Kim
A1  - Perez-Cornago, Aurora
A1  - Key, Timothy J.
A1  - Brennan, Paul
A1  - Johansson, Mattias
A1  - Tjonneland, Anne
A1  - Halkjaer, Jytte
A1  - Boutron-Ruault, Marie-Christine
A1  - Artaud, Fanny
A1  - Severi, Gianluca
A1  - Kaaks, Rudolf
A1  - Schulze, Matthias Bernd
A1  - Bergmann, Manuela M.
A1  - Masala, Giovanna
A1  - Grioni, Sara
A1  - Simeon, Vittorio
A1  - Tumino, Rosario
A1  - Sacerdote, Carlotta
A1  - Skeie, Guri
A1  - Rylander, Charlotta
A1  - Borch, Kristin Benjaminsen
A1  - Quiros, J. Ramon
A1  - Rodriguez-Barranco, Miguel
A1  - Chirlaque, Maria-Dolores
A1  - Ardanaz, Eva
A1  - Amiano, Pilar
A1  - Drake, Isabel
A1  - Stocks, Tanja
A1  - Haggstrom, Christel
A1  - Harlid, Sophia
A1  - Ellingjord-Dale, Merete
A1  - Riboli, Elio
A1  - Tsilidis, Konstantinos K.
T1  - Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1373 
KW  - BMI change
KW  - cancer
KW  - middle adulthood
KW  - weight gain
KW  - weight loss
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-573609
SN  - 1866-8372
IS  - 7
ER  -