TY  - JOUR
A1  - Schürmann, Robin Mathis
A1  - Tsering, Thupten
A1  - Tanzer, Katrin
A1  - Denifl, Stephan
A1  - Kumar, S. V. K.
A1  - Bald, Ilko
T1  - Resonant Formation of Strand Breaks in Sensitized Oligonucleotides Induced by Low-Energy Electrons (0.5-9 eV)
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - Halogenated nucleobases are used as radiosensitizers in cancer radiation therapy, enhancing the reactivity of DNA to secondary low-energy electrons (LEEs). LEEs induce DNA strand breaks at specific energies (resonances) by dissociative electron attachment (DEA). Although halogenated nucleobases show intense DEA resonances at various electron energies in the gas phase, it is inherently difficult to investigate the influence of halogenated nucleobases on the actual DNA strand breakage over the broad range of electron energies at which DEA can take place (<12 eV). By using DNA origami nanostructures, we determined the energy dependence of the strand break cross-section for oligonucleotides modified with 8-bromoadenine ((8Br)A). These results were evaluated against DEA measurements with isolated (8Br)A in the gas phase. Contrary to expectations, the major contribution to strand breaks is from resonances at around 7 eV while resonances at very low energy (<2 eV) have little influence on strand breaks.
KW  - cancer radiation therapy
KW  - dissociative electron attachment
KW  - DNA origami
KW  - DNA radiation damage
KW  - radiosensitizers
Y1  - 2017
U6  - https://doi.org/10.1002/anie.201705504
SN  - 1433-7851
SN  - 1521-3773
VL  - 56
SP  - 10952
EP  - 10955
PB  - Wiley-VCH
CY  - Weinheim
ER  -