TY  - JOUR
A1  - Chen, Ye
A1  - Song, Qilei
A1  - Zhao, Junpeng
A1  - Gong, Xiangjun
A1  - Schlaad, Helmut
A1  - Zhang, Guangzhao
T1  - Betulin-Constituted multiblock amphiphiles for broad-spectrum protein resistance
JF  - ACS applied materials & interfaces
N2  - Multiblock-like amphiphilic polyurethanes constituted by poly(ethylene oxide) and biosourced betulin are designed for antifouling and synthesized by a convenient organocatalytic route comprising tandem chain-growth and step-growth polymerizations. The doping density of betulin (D-B) in the polymer chain structure is readily varied by a mixed-initiator strategy. The spin-coated polymer films exhibit unique nanophase separation and protein resistance behaviors. Higher D-B leads to enhanced surface hydrophobicity and, unexpectedly, improved protein resistance. It is found that the surface holds molecular-level heterogeneity when D-B is substantially high due to restricted phase separation; therefore, broad-spectrum protein resistance is achieved despite considerable surface hydrophobicity. As D-B decreases, the distance between adjacent betulin units increases so that hydrophobic nanodomains are formed, which provide enough landing areas for relatively small-sized proteins to adsorb on the surface.
KW  - amphiphilic surface
KW  - antifouling
KW  - multiblock copolymer
KW  - organocatalytic polymerization
KW  - renewable resource
Y1  - 2018
U6  - https://doi.org/10.1021/acsami.7b16255
SN  - 1944-8244
VL  - 10
IS  - 7
SP  - 6593
EP  - 6600
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Schönemann, Eric
A1  - Koc, Julian
A1  - Aldred, Nick
A1  - Clare, Anthony S.
A1  - Laschewsky, André
A1  - Rosenhahn, Axel
A1  - Wischerhoff, Erik
T1  - Synthesis of Novel Sulfobetaine Polymers with Differing Dipole Orientations in Their Side Chains, and Their Effects on the Antifouling Properties
JF  - Macromolecular rapid communications
N2  - The impact of the orientation of zwitterionic groups, with respect to the polymer backbone, on the antifouling performance of thin hydrogel films made of polyzwitterions is explored. In an extension of the recent discussion about differences in the behavior of polymeric phosphatidylcholines and choline phosphates, a quasi-isomeric set of three poly(sulfobetaine methacrylate)s is designed for this purpose. The design is based on the established monomer 3-[N-2-(methacryloyloxy)ethyl-N,N-dimethyl]ammonio-propane-1-sulfonate and two novel sulfobetaine methacrylates, in which the positions of the cationic and the ionic groups relative to the polymerizable group, and thus also to the polymer backbone, are altered. The effect of the varied segmental dipole orientation on their water solubility, wetting behavior by water, and fouling resistance is compared. As model systems, the adsorption of the model proteins bovine serum albumin (BSA), fibrinogen, and lysozyme onto films of the various polyzwitterion surfaces is studied, as well as the settlement of a diatom (Navicula perminuta) and barnacle cyprids (Balanus improvisus) as representatives of typical marine fouling communities. The results demonstrate the important role of the zwitterionic group's orientation on the polymer behavior and fouling resistance.
KW  - antifouling
KW  - coatings
KW  - crosslinking
KW  - hydrophilic polymers
KW  - polyzwitterions
Y1  - 2019
U6  - https://doi.org/10.1002/marc.201900447
SN  - 1022-1336
SN  - 1521-3927
VL  - 41
IS  - 1
PB  - Wiley-VCH
CY  - Weinheim
ER  -