TY - JOUR A1 - Trippo, Ulrike A1 - Koebnick, Corinna A1 - Zunft, Hans-Joachim Franz A1 - Greil, Hans T1 - Bioelectrical impedance analysis for predicting body composition : what about the external validity of new regression equations? Y1 - 2004 SN - 0002-9165 ER - TY - JOUR A1 - Simchen, U A1 - Koebnick, Corinna A1 - Hoyer, Stephan W. A1 - Issanchou, S A1 - Zunft, Hans-Joachim Franz T1 - Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight N2 - Background: Sensory factors are important determinants of appetite and food choices but little is known about the relationship between body weight and sensory capabilities. Objective: To investigate the relationship between measured body weights, misreporting of body weight and sensory capabilities. Design: In a cross-sectional sensory study, body weight was assessed by measured and self-reported body weight in healthy men ( n = 130) and women ( n = 181). Sensory capabilities were assessed as odour detection and identification, and detection for salty, sweet, sour and bitter taste. Results: Odour detection, odour identification and taste perception scores were lower in subjects with a BMI >= 28 kg/m(2) than in subjects with a BMI < 28 kg/m(2) in the age group < 65 years whereas in subjects >= 65 years scores were higher in subjects with a BMI >= 28 kg/m(2) than in subjects with a BMI < 28 kg/m(2) ( BMI*age group: P = 0.015, 0.053 and 0.015, respectively). Independent of age, scores were highest in under reporters of body weight ( P = 0.008, 0.001 and 0.017). Differences in taste perception could be attributed to sour ( P 0.015) and bitter ( P = 0.026) perception, but not to salty or sweet perception. Conclusion: Relationship between sensory capabilities and body mass is age dependent. Compared to overweight subjects, the sensory capabilities of normal weight individuals appear to be higher ( < 65 years) and lower ( >= 65 years). At any age, however, subjects who under reported their body weight show higher sensory capabilities Y1 - 2006 ER - TY - JOUR A1 - Koebnick, Corinna A1 - Zunft, Hans-Joachim Franz T1 - Potential of dietary fibre from carob pods in the prevention and therapy of hypercholesterolemia and metabolic syndrome N2 - Soluble, viscous, but not insoluble dietary fibre has been shown to lower serum cholesterol. Due to the high content of polyphenols, however, insoluble dietary fibre from carob pods may have physiological benefits beyond those of the usual insoluble dietary fibre preparations. Insoluble polyphenol-rich fibre preparations from carob pods have also been shown to significantly lower serum total and LDL cholesterol in cholesterol-fed rodents (hamsters, rats), while HDL and triglycerides remained unchanged. An increased fecal excretion of bile acids caused by binding to the fibre constituents is supposed to be responsible for this effect. In human studies, consumption of 15 g/d of a carob fibre preparation over 6 weeks lowered LDL cholesterol by 11.0% in hypercholesterolemic subjects. This suggests that carob fibre may be effective in the dietary treatment of hypercholesterolernia. Recent studies have also shown that dietary fiber rich in polyphenols may (1) lower the glycemic index of food and (2) have anti-inflammatory effect. If carob fibre shows similar effects, it may be of special interest in the treatment of the metabolic syndrome Y1 - 2004 SN - 0174-0008 ER - TY - JOUR A1 - Koebnick, Corinna A1 - Wagner, K. A1 - Thielecke, F. A1 - Moeseneder, Jutta A1 - Hoehne, A. A1 - Franke, A. A1 - Meyer, H. A1 - Garcia, Ada A1 - Trippo, U. A1 - Zunft, Hans-Joachim Franz T1 - Validation of a simplified physical activity record by doubly labeled water technique N2 - INTRODUCTION: For obtaining reliable information about physical activity in epidemiological studies, validated and easy-to-use instruments are required. Therefore, a new simplified physical activity record based on 15-min recording intervals was developed and validated. SUBJECTS: Nonobese volunteers (n = 31). MEASUREMENTS: Physical activity was recorded over a 7-day period without detailed instructions. Energy expenditure was calculated (EEsPAR) and compared to energy expenditure measured by doubly labelled water technique (EEDLW). RESULTS: A good agreement between EEsPAR (12.1 +/ 3.0) and EEDLW (11.7 +/- 3.3) with a mean difference of 0.33 +/- 1.55 MJ (r = 0.880, P < 0.001) was observed. The absolute difference between EEsPAR and EEDLW was <10% in 65% of the subjects. The difference between EEsPAR and EEDLW was independent of gender, age, body weight, and body mass index. A weak positive association between the difference and total body fat was observed (r = 0.618, P < 0.001), suggesting a slight tendency to overestimate EEsPAR with increasing total body fat. CONCLUSION: The new simplified physical activity protocol needs no detailed instructions, provides valid estimates of physical activity in nonobese free-living adults and can be used in epidemiological studies to assess total daily energy expenditure and physical activity level Y1 - 2005 SN - 0307-0565 ER - TY - JOUR A1 - Koebnick, Corinna A1 - Wagner, K. A1 - Thielecke, F. A1 - Dieter, G. A1 - Hohne, A. A1 - Franke, A. A1 - Garcia, Ada A1 - Meyer, H. A1 - Hoffmann, I. A1 - Leitzmann, P. A1 - Trippo, U. A1 - Zunft, Hans-Joachim Franz T1 - An easy-to-use semiquantitative food record validated for energy intake by using doubly labelled water technique N2 - Background: Estimating dietary intake is important for both epidemiological and clinical studies, but often lacks accuracy. Objective: To investigate the accuracy and validity of energy intake estimated by an easy-to-use semiquantitative food record (EISQFR) compared to total energy expenditure ( TEE) estimated by doubly labelled water technique (EEDLW). Design: TEE was measured in 29 nonobese subjects using the doubly labelled water method over a period of 14 days. Within this period, subjects reported their food consumption by a newly developed semiquantitative food record for 4 consecutive days. Energy intake was calculated using the German Food Code and Nutrition Data Base BLS II.3. Results: A good correlation was observed between EISQFR and EEDLW (r = 0.685, P<0.001). The mean difference between EISQFR and EEDLW was - 1.7 +/- 2.6 MJ/ day ( - 14 +/- 21%, P = 0.002). An underestimation of EISQFR <10% was observed in nine subjects (31%), of 10 - 20% in six subjects (21%), and of >20% in nine subjects (31%). In five subjects (17%), an overestimation of EISQFR was observed. Conclusions: The easy-to-use semiquantitative food record provided good estimates of EI in free-living and nonobese adults without prior detailed verbal instructions. The presented food record has limitations regarding accuracy at the individual level Y1 - 2005 SN - 0954-3007 ER - TY - JOUR A1 - Koebnick, Corinna A1 - Plank-Habibi, S. A1 - Wirsam, B. A1 - Gruendel, Sindy A1 - Hahn, A. A1 - Meyer-Kleine, C. A1 - Leitzmann, C. A1 - Zunft, Hans-Joachim Franz T1 - Double-blind, randomized feedback control fails to improve the hypocholesterolemic effect of a plant-based low- fat diet in patients with moderately elevated total cholesterol levels N2 - Objective: To determine whether the cholesterol-lowering effect of a plant-based low-fat diet can be improved by a flexible control design that controls the extent of fat reduction based on the individual response of blood cholesterol. Design: Randomized, double-blind intervention study. Setting: A hotel in Prerow, Germany. Subjects: A total of 32 participants ( 21 female and 11 male participants) with total cholesterol level >5.7 mmol/l. Intervention: The control group consumed a plant-based low-fat diet with constantly 20% of energy as fat; the intervention group received a diet with either 20 or 15% of energy as fat, depending on the serum cholesterol response of the preceding week. A flexible control design based on the individual cholesterol response during a run-in period of 1 week was used within a low-fat intervention. Results: During the run-in period, the consumption of a plant-based low-fat diet led to a reduction in total cholesterol by 18 +/- 6 mmol/l ( P<0.001), in LDL cholesterol by 19 +/- 9 mmol/l ( P<0.001) and triglycerides by 13 +/- 3 mmol/l ( P<0.001). During the feedback control period, an additional reduction in total cholesterol by 13 +/- 8 ( P<0.001) and in LDL cholesterol by 17 +/- 11 (P<0.001) was observed compared to 15715 and 7718 in the control group. The effect of an additional feedback control was only marginal and not statistically significant compared to the effect of the low-fat diet alone. Conclusions: On a level of fat intake already reduced to 20% of energy, the use of a feedback control to adapt the fat content of the diet depending on the individual serum cholesterol response was not more effective in reducing blood cholesterol levels than a plant-based low-fat diet alone. Sponsorship: Institute of Micro-Ecology, Herborn; the Stoll VITA Foundation, Waldshut; ALBAT+WIRSAM Software, Linden; Reformhaus Technical College, Oberstedten; Kolln Flocken Werke, Elmshorn, all in Germany Y1 - 2004 ER - TY - JOUR A1 - Gericke, Beate A1 - Koebnick, Corinna A1 - Reimann, Manja A1 - Forterre, Simone A1 - Zunft, Hans-Joachim Franz A1 - Schweigert, Florian J. T1 - Influence of hormone replacement therapy on proteomic pattern in serum of postmenopausal women N2 - Objectives: Proteomics approaches to cardiovascular biology and disease hold the promise of identifying specific proteins and peptides or modification thereof to assist in the identification of novel biomarkers. Method: By using surface-enhanced laser desorption and ionization time of flight mass spectroscopy (SELDI-TOF-MS) serum peptide and protein patterns were detected enabling to discriminate between postmenopausal women with and without hormone replacement therapy (HRT). Results: Serum of 13 HRT and 27 control subjects was analyzed and 42 peptides and proteins could be tentatively identified based on their molecular weight and binding characteristics on the chip surface. By using decision tree-based Biomarker Patterns (TM) Software classification and regression analysis a discriminatory function was developed allowing to distinguish between HRT women and controls correctly and, thus, yielding a sensitivity of 100% and a specificity of 100%. The results show that peptide and protein patterns have the potential to deliver novel biomarkers as well as pinpointing targets for improved treatment. The biomarkers obtained represent a promising tool to discriminate between HRT users and non-users. Conclusion: According to a tentative identification of the markers by their molecular weight and binding characteristics, most of them appear to be part of the inflammation induced acute-phase response. (c) 2004 Elsevier Ireland Ltd. All rights reserved Y1 - 2004 ER - TY - JOUR A1 - Garcia, Ada A1 - Wagner, Karen A1 - Hothorn, T. A1 - Koebnick, Corinna A1 - Zunft, Hans-Joachim Franz A1 - Trippo, Ulrike T1 - Improved prediction of body fat by measuring skinfold thickness, circumferences, and bone breadths N2 - Objective: To develop improved predictive regression equations for body fat content derived from common anthropometric measurements. Research Methods and Procedures: 117 healthy German subjects, 46 men and 71 women, 26 to 67 years of age, from two different studies were assigned to a validation and a cross-validation group. Common anthropornetric measurements and body composition by DXA were obtained. Equations using anthropometric measurements predicting body fat mass (BFM) with DXA as a reference method were developed using regression models. Results: The final best predictive sex-specific equations combining skinfold thicknesses (SF), circumferences, and bone breadth measurements were as follows: BFMNew (kg) for men = -40.750 + {(0.397 x waist circumference) + [6.568 x (log triceps SF + log subscapular SF + log abdominal SF)]} and BFMNew (kg) for women = -75.231 + {(0.512 x hip circumference) + [8.889 x (log chin SF + log triceps SF + log subscapular SF)] + (1.905 x knee breadth)}. The estimates of BFM from both validation and cross-validation had an excellent correlation, showed excellent correspondence to the DXA estimates, and showed a negligible tendency to underestimate percent body fat in subjects with higher BFM compared with equations using a two-compartment (Durnin and Womersley) or a four-compartment (Peterson) model as the reference method. Discussion: Combining skinfold thicknesses with circumference and/or bone breadth measures provide a more precise prediction of percent body fat in comparison with established SF equations. Our equations are recommended for use in clinical or epidemiological settings in populations with similar ethnic background Y1 - 2005 SN - 1071-7323 ER - TY - JOUR A1 - Garcia, Ada A1 - Wagner, Karen A1 - Einig, Christiana A1 - Trippo, Ulrike A1 - Koebnick, Corinna A1 - Zunft, Hans-Joachim Franz T1 - Evaluation of body fat changes during weight loss by using improved anthropometric predictive equations N2 - Background/Aim: Skinfold-based equations are widely used to evaluate body fat (BF), but over-/underestimation is often reported. We evaluate the capacity of improved skinfold-based equations to estimate BF changes during weight reduction and compare them against well-established equations. Methods: Overweight adults (n = 44) participated in a 4- month weight reduction intervention. Dual-energy X-ray absorptiometry (DXA) and anthropometric measurements were taken at baseline and after intervention. The BF% was calculated using Garcia, Peterson, and Durnin and Womersley (DW) equations. Results: Baseline and postintervention BF% measured by DXA correlated highest with BF% predicted according to Garcia (r = 0.934 and r = 0.948, respectively), followed by Peterson (r = 0.941 and r = 0.932, respectively) and DW (r = 0.557 and r = 0.402, respectively); only a slight systematic error in overestimating the BF% was observed in estimates according to Garcia (r = 0.147 and r = 0.104, respectively; p < 0.001), while increasing errors occurred using the Peterson (r = 0.624 and r = 0.712, respectively; p < 0.001) and DW (r = 0.767 and r = 0.769, respectively; p < 0.001) equations. Moderate correlations between BF changes (kg) measured by DXA and predicted by DW (r = 0.7211), Peterson (r = 0.697), and Garcia (r = 0.645) were observed. Conclusion: Improved skin-fold equations cannot accurately measure changes in BF after weight reduction Y1 - 2006 UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=223977 U6 - https://doi.org/10.1159/000092601 SN - 0250-6807 ER - TY - JOUR A1 - Garcia, Ada A1 - Rühl, Ralph A1 - Herz, U. A1 - Koebnick, Corinna A1 - Schweigert, Florian J. A1 - Worm, Margitta T1 - Retinoid- and carotenoid-enriched diets influence the ontogenesis of the immune system in mice Y1 - 2003 ER -